scholarly journals Acute Abdomen—A Clinical Presentation of MIS-C in Children

2021 ◽  
Author(s):  
Emrah Gün ◽  
Tanıl Kendirli ◽  
Edin Botan ◽  
Berrin Demir ◽  
Ergun Ergün ◽  
...  
Keyword(s):  
Acute Abdomen ◽  
Clinical Presentation ◽  
Surgical Intervention ◽  
Clinical Course ◽  
Treatment Options ◽  
Pediatric Intensive Care ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Pathology Reports ◽  
Inflammatory Syndrome

Abstract Objective Multisystemic inflammatory syndrome in children (MIS-C) is characterized by persistent fever, systemic hyperinflammation, and multiple-organ dysfunction. There are a few reports about MIS-C presenting with acute abdomen. The aim of this study is to demonstrate the clinical characteristics and treatment options for MIS-C-related acute abdomen and appendicitis. Methods This was a retrospective study conducted between April 2020 and October 2020 in our pediatric intensive care unit in Turkey. Patients between the ages of 1 month and 18 years who presented with acute abdomen and were ultimately diagnosed with MIS-C were included. Results Seven patients with a median age of 12.5 (interquartile range 10.5–13) years were enrolled. Four were females. The most frequent symptoms were fever, abdominal pain, and vomiting. Three patients had involvement of the appendix that required surgical intervention. All pathology reports were compatible with appendicitis. The other patients also had an acute abdomen. One patient had malignant hyperthermia during induction of anesthesia, so surgery was postponed and medical management was commenced. The clinical picture regressed with immunomodulation. All patients were treated with intravenous immunoglobulin and steroids. Four patients with acute abdomens improved with immunomodulation, and surgery was not needed. Conclusion MIS-C may present with an acute abdomen. Immunomodulation should be considered instead of surgery if the clinical course is not complicated.

scholarly journals Post-COVID-19 Kawasaki-Like Syndrome

2021 ◽  
pp. 014556132110060
Author(s):  
Jérôme R. Lechien ◽  
Rémi Hervochon ◽  
Stéphane Hans
Keyword(s):  
Abdominal Pain ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Hepatitis A ◽  
Clinical Presentation ◽  
Multiple Organ ◽  
Mild Form ◽  
Severe Dysphagia ◽  
History Of ◽  
Inflammatory Syndrome

A 42-year-old man was referred for a week history of severe dysphagia, odynophagia, fever (39 °C), fatigue, abdominal pain, pharyngeal swelling, and multiple neck lymphadenopathies. The medical history reported a mild form of COVID-19 one month ago. The biology reported an unspecified inflammatory syndrome. The patient developed peritonitis, myocarditis, and hepatitis. A myocardium biopsy was performed. A diagnosis of Kawasaki-like disease (KLD) was performed. The occurrence of KLD in adults is rare but has to be known by otolaryngologists regarding the otolaryngological clinical presentation that may precede the multiple organ failure.

Severe invasive disease caused by hypervirulent Klebsiella pneumoniae: a case report

2021 ◽  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Patient Outcomes ◽  
Liver Abscess ◽  
Pathogenic Bacteria ◽  
Treatment Options ◽  
Invasive Disease ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Antimicrobial Drugs ◽  
Life Threatening

Klebsiella pneumoniae (K. pneumoniae) is a common pathogenic bacteria that causes numerous infectious diseases. Hypervirulent K. pneumoniae (hvKP) can lead to invasive K. pneumoniae liver abscess syndrome, which can induce life-threatening multiple organ dysfunction syndrome or septic shock. We report a case of invasive K. pneumoniae liver abscess syndrome caused by hvKP and discuss the treatment options of this syndrome. Appropriate antimicrobial drugs should be administered to improve prognosis and prevent complications, and laboratory testing is essential to guide clinical management and optimize patient outcomes.

scholarly journals Fluid balance correlates with clinical course of multiple organ dysfunction syndrome and mortality in patients with septic shock

PLoS ONE ◽  
2019 ◽  
Vol 14 (12) ◽  
pp. e0225423
Author(s):  
Allen Chung-Cheng Huang ◽  
Tim Yu-Ting Lee ◽  
Meng-Cheng Ko ◽  
Chih-Hsien Huang ◽  
Tsai-Yu Wang ◽  
...  
Keyword(s):  
Septic Shock ◽  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Fluid Balance ◽  
Clinical Course ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction

scholarly journals Acute kidney injury in pediatric patients: experience of a single center during an 11-year period

Medicina ◽  
2010 ◽  
Vol 46 (8) ◽  
pp. 511 ◽  
Author(s):  
Birutė Pundzienė ◽  
Diana Dobilienė ◽  
Šarūnas Rudaitis
Keyword(s):  
Intensive Care Unit ◽  
Acute Kidney Injury ◽  
Intensive Care ◽  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Kidney Injury ◽  
Pediatric Intensive Care ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Second Period

The aim of our study was to determine the causes of acute kidney injury (AKI) in children, to compare outcomes between two periods – 1998–2003 and 2004-2008 – and to evaluate the influence of new methods of renal replacement therapy on mortality. Material and methods. A retrospective analysis of medical record data of all children treated for AKI at the Clinic of Children Diseases, Hospital of Kaunas University of Medicine, during the period of 1998–2008 was made. Both periods were compared regarding various variables. Results. Of the 179 children with AKI, 75 (41.9%) were treated during 1998–2003 and 104 (58.1%) during 2004–2008. Primary glomerular disease and sepsis were the leading causes of AKI in both the periods. AKI without involvement of other organs was diagnosed for 106 (59.2%) children: for 42 (56.0%) children in the first period and 64 (61.5%) in the second. A total of 124 (69.3%) children were treated in a pediatric intensive care unit. Multiple organ dysfunction syndrome with AKI was diagnosed for 33 (44%) patients in the first period and for 40 (38.5%) in the second. A significant decrease in mortality among patients with multiple organ dysfunction syndrome during the second period was observed (78.8% vs. 37.5%). Conclusions. More than half of patients had secondary acute kidney injury of nonrenal origin. More than two-thirds (69.3%) of patients with AKI were treated in the pediatric intensive care unit. Multiple organ dysfunction syndrome was diagnosed for 40.8% of children with AKI. Renal replacement therapy was indicated for one-third of patients with AKI. A 2.5-fold decrease in mortality was observed in the second period as compared to the first one.

scholarly journals Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management

Children ◽  
2020 ◽  
Vol 7 (7) ◽  
pp. 69 ◽  
Author(s):  
Natasha A. Nakra ◽  
Dean A. Blumberg ◽  
Angel Herrera-Guerra ◽  
Satyan Lakshminrusimha
Keyword(s):  
Clinical Presentation ◽  
Pediatric Intensive Care ◽  
Severe Illness ◽  
Toxic Shock ◽  
Epidemiologic Evidence ◽  
Organ Systems ◽  
Relationship Of ◽  
Inflammatory Syndrome ◽  
The Relationship ◽  
Secondary Hemophagocytic Lymphohistiocytosis

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may result in the multisystem inflammatory syndrome in children (MIS-C). The clinical presentation of MIS-C includes fever, severe illness, and the involvement of two or more organ systems, in combination with laboratory evidence of inflammation and laboratory or epidemiologic evidence of SARS-CoV-2 infection. Some features of MIS-C resemble Kawasaki Disease, toxic shock syndrome, and secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome. The relationship of MIS-C to SARS-CoV-2 infection suggests that the pathogenesis involves post-infectious immune dysregulation. Patients with MIS-C should ideally be managed in a pediatric intensive care environment since rapid clinical deterioration may occur. Specific immunomodulatory therapy depends on the clinical presentation. The relationship between the immune response to SARS-CoV-2 vaccines in development and MIS-C requires further study.

scholarly journals Infantile Hemangioma: An Overview

2015 ◽  
Vol 1 (4) ◽  
pp. 69-71
Author(s):  
Prema Dhanraj
Keyword(s):  
Laser Surgery ◽  
Surgical Intervention ◽  
Clinical Course ◽  
Treatment Options ◽  
Surgical Excision ◽  
Infantile Hemangioma ◽  
Intervention Treatment ◽  
Vascular Neoplasms ◽  
Spontaneous Involution ◽  
Clinically Significant

ABSTRACT Infantile hemangiomas (IH) are benign vascular neoplasms that have a characteristic clinical course marked by early proliferation and followed by spontaneous involution. Hemangiomas are the most common tumors of infancy and usually are medically insignificant. The vast majority of infantile hemangiomas do not require any medical or surgical intervention. Treatment options for clinically significant hemangiomas include, laser surgery, surgical excision or Medication. How to cite this article Dhanraj P. Infantile Hemangioma: An Overview. J Med Sci 2015;1(4):69-71.

scholarly journals A CLINICAL PRESENTATION AND SURGICAL MANAGEMENT OF ABDOMINAL TUBERCULOSIS AT IMCHRC, INDORE

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Dr. Anil Kumar Baxi ◽  
Dr. Vasant Dakwale ◽  
Dr. Namrata Mishra
Keyword(s):  
Observational Study ◽  
Acute Abdomen ◽  
Surgical Management ◽  
Prospective Observational Study ◽  
Clinical Presentation ◽  
Surgical Intervention ◽  
Abdominal Tuberculosis ◽  
Acute Presentation ◽  
Different Types

Tuberculosis is an important cause of morbidity in India. Abdominal Tuberculosis is difficult to diagnose. This prospective observational study is based on those patients who were diagnosed to be suffering from Abdominal Tuberculosis only after they presented with an acute abdomen. This study aims to document the nature of different types of acute presentation in Abdominal Tuberculosis according to concerned clinical presentation & surgical management. The study also discusses the indications and extent of surgical intervention. Keywords: Surgical, Abdominal & Tuberculosis.

scholarly journals Pediatric Crohn's Disease

2018 ◽  
Vol 31 (02) ◽  
pp. 080-088 ◽  
Author(s):  
Daniel von Allmen
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Older Patients ◽  
Pediatric Patients ◽  
Clinical Presentation ◽  
Surgical Intervention ◽  
Clinical Course ◽  
Pediatric Population ◽  
Medical Treatments ◽  
Course Of Disease

AbstractThe incidence of Crohn's disease in the pediatric population is increasing. While pediatric patients with Crohn's disease exhibit many of the characteristics of older patients, there are important differences in the clinical presentation and course of disease that can impact the clinical decisions made during treatment. The majority of children are diagnosed in the early teen years, but subgroups of very early onset and infantile Crohn's present much earlier and have a unique clinical course. Treatment paradigms follow the traditional laddered approach, but growth and development represent special considerations that must be given to pediatric-specific complications of the treatment and disease. Surgical intervention is an important component of Crohn's management and is often employed to allow improved nutritional intake or decrease reliance on medical treatments that compromise growth.

scholarly journals Insights into the management of gastric antral vascular ectasia (watermelon stomach)

2018 ◽  
Vol 11 ◽  
pp. 1756283X1774747 ◽  
Author(s):  
Wen-Hung Hsu ◽  
Yao-Kuang Wang ◽  
Meng-Shu Hsieh ◽  
Fu-Chen Kuo ◽  
Meng-Chieh Wu ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Surgical Intervention ◽  
Treatment Options ◽  
Occult Blood ◽  
Deficiency Anemia ◽  
Gastric Antral Vascular Ectasia ◽  
Efficacy And Safety ◽  
Vascular Ectasia ◽  
Therapeutic Modalities ◽  
Chronic Gastrointestinal Bleeding

Gastric antral vascular ectasia (GAVE) is an uncommon but important cause of chronic gastrointestinal bleeding. It is often associated with systemic diseases such as autoimmune diseases, liver cirrhosis, chronic renal insufficiency and cardiovascular disease. The etiology of GAVE has not been fully explored and remains controversial. Diagnosis is mainly based on endoscopic presentation with flat or raised erythematous stripes radiating from the pylorus to the antrum and resembles a watermelon. Clinical presentation may range from iron-deficiency anemia secondary to occult blood loss, melena to hematemesis. In past decades, many therapeutic modalities including medical, endoscopic and surgical intervention have been introduced for GAVE treatment with variable efficacy. Herein, we review the efficacy and safety of these treatment options for GAVE.

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