scholarly journals First Carpometacarpal Joint Anatomy and Osteoarthritis: MR Imaging Overview

2022 ◽  
Author(s):  
Kanagasabai Kamalasekar ◽  
Reddy Ravikanth
Keyword(s):  
High Field ◽  
Mri Imaging ◽  
Resonance Imaging ◽  
Carpometacarpal Joint ◽  
First Carpometacarpal Joint ◽  
Predictable Pattern ◽  
Anterior Oblique Ligament ◽  
High Resolution Images ◽  
Magnetic Resonance Imaging Mri ◽  
Cmc Joint

AbstractThe first carpometacarpal (CMC) joint consists of seven ligaments. The magnetic resonance imaging (MRI) examination of the first CMC joint should be performed in a high field 1.5/3 T MRI with a dedicated hand coil for high-resolution images. Degeneration of anterior oblique ligament (AOL) is the most important cause for the development of osteoarthritis of first CMC joint. Since the AOL undergoes a predictable pattern of alteration at its metacarpal attachment as degeneration proceeds, MRI imaging can provide an accurate assessment of this ligament.

scholarly journals Magnetic Resonance Imaging in Animal Models of Alzheimer’s Disease Amyloidosis

2021 ◽  
Author(s):  
Ruiqing Ni
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Animal Models ◽  
Amyloid Beta ◽  
High Field ◽  
Diffusion Tensor ◽  
Small Animal ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri

Amyloid-beta plays an important role in the pathogenesis of Alzheimer’s disease. Aberrant amyloid-beta and tau accumulation induce neuroinflammation, cerebrovascular alterations, synaptic deficits, functional deficits, and neurodegeneration, leading to cognitive impairment. Animal models recapitulating the amyloid-beta pathology such as transgenic, knock-in mouse and rat models have facilitated the understanding of disease mechanisms and development of therapeutics targeting at amyloid-beta. There is a rapid advance in high-field MR in small animals. Versatile high-field magnetic resonance imaging (MRI) sequences such as diffusion tensor imaging, arterial spin labelling, resting-state functional MRI, anatomical MRI, MR spectroscopy as well as contrast agents have been developed for the applications in animal models. These tools have enabled high-resolution in vivo structural, functional, and molecular readouts with a whole brain field-of-view. MRI have been utilized to visualize non-invasively the amyloid-beta deposits, synaptic deficits, regional brain atrophy, impairment in white matter integrity, functional connectivity, cerebrovascular and glymphatic system in animal models of amyloidosis. Many of the readouts are translational in clinical MRI in the brain of patients with Alzheimer’s disease. In this review, we summarize the recent advance of using MRI for visualizing the pathophysiology in amyloidosis animal model. We discuss the outstanding challenges in brain imaging using MRI in small animal and propose future outlook in visualizing amyloid-beta-related alterations in brain of animal models.

scholarly journals Recent Advances in Lanthanide Based Nano-Architectures as Probes for Ultra High-Field Magnetic Resonance Imaging

2020 ◽  
Vol 27 (3) ◽  
pp. 352-361 ◽  
Author(s):  
Silvanose Biju ◽  
Tatjana N. Parac-Vogt
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
High Field ◽  
Imaging Modality ◽  
Short Review ◽  
Mri Contrast Agents ◽  
Lanthanide Ions ◽  
Resonance Imaging ◽  
Multiple Imaging ◽  
Magnetic Resonance Imaging Mri

Paramagnetic Lanthanide ions incorporated into nano- architectures are emerging as a versatile platform for Magnetic Resonance Imaging (MRI) contrast agents due to their strong contrast enhancement effects combined with the platform capability to include multiple imaging modalities. This short review examines the application of lanthanide based nanoarchitectures (nanoparticles and nano- assemblies) in the development of multifunctional probes for single and multimodal imaging involving high field MRI as one imaging modality.

scholarly journals MRI Radiomics in Prostate Cancer: A Reliability Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Fabrizio Urraro ◽  
Valerio Nardone ◽  
Alfonso Reginelli ◽  
Carlo Varelli ◽  
Antonio Angrisani ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Region Of Interest ◽  
Texture Features ◽  
Mri Imaging ◽  
Resonance Imaging ◽  
Clinical Endpoints ◽  
Standardized Protocol ◽  
Coefficient Corrélation ◽  
Magnetic Resonance Imaging Mri ◽  
Cancer Lesion

BackgroundRadiomics can provide quantitative features from medical imaging that can be correlated to clinical endpoints. The challenges relevant to robustness of radiomics features have been analyzed by many researchers, as it seems to be influenced by acquisition and reconstruction protocols, as well as by the segmentation of the region of interest (ROI). Prostate cancer (PCa) represents a difficult playground for this technique, due to discrepancies in the identification of the cancer lesion and the heterogeneity of the acquisition protocols. The aim of this study was to investigate the reliability of radiomics in PCa magnetic resonance imaging (MRI).MethodsA homogeneous cohort of patients with a PSA rise that underwent multiparametric MRI imaging of the prostate before biopsy was tested in this study. All the patients were acquired with the same MRI scanner, with a standardized protocol. The identification and the contouring of the region of interest (ROI) of an MRI suspicious cancer lesion were done by two radiologists with great experience in prostate cancer (>10 years). After the segmentation, the texture features were extracted with LIFEx. Texture features were then tested with intraclass coefficient correlation (ICC) analysis to analyze the reliability of the segmentation.ResultsForty-four consecutive patients were included in the present analysis. In 26 patients (59.1%), the prostate biopsy confirmed the presence of prostate cancer, which was scored as Gleason 6 in 6 patients (13.6%), Gleason 3 + 4 in 8 patients (18.2%), and Gleason 4 + 3 in 12 patients (27.3%). The reliability analysis conversely showed poor reliability in the majority of the MRI acquisition (61% in T2, 89% in DWI50, 44% in DWI400, and 83% in DWI1,500), with ADC acquisition only showing better reliability (poor reliability in only 33% of the texture features).ConclusionsThe low ratio of reliability in a monoinstitutional homogeneous cohort represents a significant alarm bell for the application of MRI radiomics in the field of prostate cancer. More work is needed in a clinical setting to further study the potential of MRI radiomics in prostate cancer.

scholarly journals Hybrid PET–MRI Imaging in Paediatric and TYA Brain Tumours: Clinical Applications and Challenges

2020 ◽  
Vol 10 (4) ◽  
pp. 218
Author(s):  
Ananth Shankar ◽  
Jamshed Bomanji ◽  
Harpreet Hyare
Keyword(s):  
Brain Tumours ◽  
Therapeutic Assessment ◽  
Mri Imaging ◽  
Resonance Imaging ◽  
Single Centre ◽  
Positron Emission ◽  
Early Treatment Response ◽  
Single Centre Experience ◽  
Magnetic Resonance Imaging Mri ◽  
Standard Magnetic Resonance Imaging

(1) Background: Standard magnetic resonance imaging (MRI) remains the gold standard for brain tumour imaging in paediatric and teenage and young adult (TYA) patients. Combining positron emission tomography (PET) with MRI offers an opportunity to improve diagnostic accuracy. (2) Method: Our single-centre experience of 18F-fluorocholine (FCho) and 18fluoro-L-phenylalanine (FDOPA) PET–MRI in paediatric/TYA neuro-oncology patients is presented. (3) Results: Hybrid PET–MRI shows promise in the evaluation of gliomas and germ cell tumours in (i) assessing early treatment response and (ii) discriminating tumour from treatment-related changes. (4) Conclusions: Combined PET–MRI shows promise for improved diagnostic and therapeutic assessment in paediatric and TYA brain tumours.

scholarly journals Prostatic Utricle Cyst as the Most Likely Cause in a Case of Recurrent Episodes of Hematospermia

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Grégoire Feutry ◽  
Thomas De Perrot ◽  
Gregory J. Wirth ◽  
Xavier Montet ◽  
Steve P. Martin
Keyword(s):  
High Field ◽  
Cystic Lesion ◽  
Transrectal Ultrasound ◽  
Resonance Imaging ◽  
Endorectal Coil ◽  
Prostatic Utricle ◽  
Virgin Male ◽  
Magnetic Resonance Imaging Mri ◽  
Prostatic Utricle Cyst ◽  
Prostatic Cyst

Hematospermia is a clinical symptom that raises anxiety in patients and has various causes, benign and malignant. We report a case of hematospermia for which appropriate multidisciplinary expertise favored a conservative management of a benign prostatic cyst, namely, a prostatic utricle cyst. A cystic lesion found by transrectal ultrasound in the context of hematospermia related to masturbation in a young virgin male patient was investigated with a high-field magnetic resonance imaging (MRI) and an endorectal coil. The association of high-field MRI and endorectal coil leads to high quality images.

Evaluation of Magnetic Resonance Imaging Responsiveness in Active Psoriatic Arthritis at Multiple Timepoints during the First 12 Weeks of Antitumor Necrosis Factor Therapy

2015 ◽  
Vol 43 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Marie Feletar ◽  
Stephen Hall ◽  
Paul Bird
Keyword(s):  
Magnetic Resonance Imaging ◽  
Psoriatic Arthritis ◽  
Magnetic Resonance ◽  
High Field ◽  
Early Response ◽  
Resonance Imaging ◽  
Low Field ◽  
Low Field Mri ◽  
Magnetic Resonance Imaging Mri ◽  
Necrosis Factor

Objective.To assess the responsiveness of high- and low-field extremity magnetic resonance imaging (MRI) variables at multiple timepoints in the first 12 weeks post-antitumor necrosis factor (anti-TNF) therapy initiation in patients with psoriatic arthritis (PsA) and active dactylitis.Methods.Twelve patients with active PsA and clinical evidence of dactylitis involving at least 1 digit were recruited. Patients underwent sequential high-field conventional (1.5 Tesla) and extremity low-field MRI (0.2 Tesla) of the affected hand or foot, pre- and postgadolinium at baseline (pre-TNF), 2 weeks (post-TNF), 6 weeks, and 12 weeks. A blinded observer scored all images on 2 occasions using the PsA MRI scoring system.Results.Eleven patients completed the study, but only 6 patients completed all high-field and low-field MRI assessments. MRI scores demonstrated rapid response to TNF inhibition with score reduction in tenosynovitis, synovitis, and osteitis at 2 weeks. Intraobserver reliability was good to excellent for all variables. High-field MRI demonstrated greater sensitivity to tenosynovitis, synovitis, and osteitis and greater responsiveness to change posttreatment. Treatment responses were maintained to 12 weeks.Conclusion.This study demonstrates the use of MRI in detecting early response to biologic therapy. MRI variables of tenosynovitis, synovitis, and osteitis demonstrated responsiveness posttherapy with high-field scores more responsive to change than low-field scores.

scholarly journals Identification of hippocampal cortical microinfarcts on postmortem 3-T magnetic resonance imaging

2021 ◽  
Author(s):  
Max Scheffler ◽  
Rares Salomir ◽  
Enrique Maturana ◽  
Marie-Louise Montandon ◽  
Enikö V. Kövari ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cognitive Impairment ◽  
Magnetic Resonance ◽  
High Field ◽  
Correlation Study ◽  
Post Mortem ◽  
Resonance Imaging ◽  
Ultra High Field ◽  
Magnetic Resonance Imaging Mri ◽  
Double Blinded

AbstractCortical microinfarcts (CMI) are increasingly recognized in the neurological community as a biomarker related to cognitive impairment and dementia. If their radiological depiction has been largely described in experimental settings using ultra-high-field magnetic resonance imaging (MRI), less is known about their visibility on routinely used 3-T MRI. In this radiologic-pathologic correlation study, using 3-T post-mortem MRI, we searched for hippocampal CMI, in a double-blinded fashion, and found that only 4/36, or 11%, were clearly demonstrated on both radiological and histopathological exams.

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