The last five years defined an alternative course in the US foreign policy. Obama's reelection caused staff transfers which notably influenced the course. This comprehensive process is based on tremendous work conducted by the Administration of Barak Obama, in particular by John Kerry, who was appointed as a Secretary of State in 2013. His personality plays a significant role in American domestic and foreign policy interrelation. Adoption or rejection of the bills, which are well-known today, depended in large on a range of circumstances, such as personality, life journey and political leader career of the today's Secretary of State. John Kerry’s professional life is mainly associated with domestic policy; nevertheless, he has always been interested in foreign relations and national security issues. Those concerns generally included: non-proliferation, US security, ecological problems, fight against terrorism. The article is intended to highlight Kerry’s efforts in each of these fields, showing not only his actions, but also difficult process of adoption or banning bills in the USA. The author tried to display the whole complicated decision-making process among different parties, businessmen and politicians, law and money clashes. The results of many former endeavors can be seen today, in the modern US policy. Based on assumptions about Secretary of State’s beliefs, certain road map can be predicted. In conclusion, the article offers several courses, where the United States are likely to be most active during the next few years. It can be judged exactly which way some current political issues will develop, how the US foreign policy will be shaped by today's decision-makers in the White House.