New simulation approach using classical formalism to water nuclear magnetic relaxation dispersions in presence of superparamagnetic particles used as MRI contrast agents

2012 ◽  
Vol 137 (11) ◽  
pp. 114505 ◽  
Author(s):  
Q. L. Vuong ◽  
Y. Gossuin ◽  
P. Gillis ◽  
S. Delangre
Keyword(s):  
Contrast Agents ◽  
Magnetic Relaxation ◽  
Mri Contrast Agents ◽  
Nuclear Magnetic Relaxation ◽  
Simulation Approach ◽  
Mri Contrast ◽  
Superparamagnetic Particles ◽  
Classical Formalism ◽  
Nuclear Magnetic

scholarly journals Digital Simulation Assessments of the Sensitivity of Quantitative MRI for Detection of an Iron Oxide Nanoparticle Brain MRI Contrast Agent

2021 ◽  
Author(s):  
Joong Kim ◽  
Wen-Tung Wang ◽  
Andrew Knutsen ◽  
David Brody
Keyword(s):  
Iron Oxide ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Digital Simulation ◽  
Brain Mri ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
Simulation Approach ◽  
Mri Contrast ◽  
Mr Relaxation

Abstract There have been substantial efforts to develop targeted exogenous MRI contrast agents to assess specific brain pathologies. In parallel with other efforts, it is important to assess the sensitivity of candidate MRI methods for detection of contrast agents. Here, we propose a digital simulation approach, which includes MR relaxation (R1 and R2) mapping and image co-registration. We simulated the effects of 3 nm iron oxide nanoparticles (IONPs) as a model contrast agent. Two independent relaxation maps acquired from the brain of the same subject were co-registered. The baseline subtraction between the two relaxation maps showed good agreement, demonstrating the high reproducibility of the method. Next, the second relaxation map was digitally altered (“seeded”) to simulate additional MR relaxation values corresponding to several concentrations of 3 nm IONPs in various locations. The maps of absolute differences between the first relaxation map and the digitally altered second relaxation maps were assessed for conspicuity. Results based on living mouse and human brains scanned at 9.4 T and 3.0 T respectively both indicated reliable conspicuity for signal equivalent to 0.06 mM IONP or higher. Overall, the digital simulation approach is a useful method to improve the development of MRI contrast agents and accompanying MRI methodologies.

3He NUCLEAR MAGNETIC RELAXATION BEHAVIOURS IN HCP SOLID 3He WITH 4He IMPURITIES

1978 ◽  
Vol 39 (C6) ◽  
pp. C6-115-C6-116 ◽  
Author(s):  
S. Maegawa ◽  
T. Mizusaki ◽  
Y. Hirayochi ◽  
T. Kusumoto ◽  
A. Hirai
Keyword(s):  
Magnetic Relaxation ◽  
Nuclear Magnetic Relaxation ◽  
Solid 3He ◽  
Nuclear Magnetic
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