Failure of sperm transport in relation to ewe infertility following prolonged grazing on oestrogenic pastures

1967 ◽  
Vol 18 (5) ◽  
pp. 755 ◽  
Author(s):  
RJ Lightfoot ◽  
KP Croker ◽  
HG Neil
Keyword(s):  
Fallopian Tube ◽  
Zona Pellucida ◽  
Cervix Uterus ◽  
The Other ◽  
Ovarian Activity ◽  
Fallopian Tubes ◽  
Motile Sperm ◽  
Sperm Transport ◽  
Causal Mechanisms ◽  
To Receive

Sixteen ewes were drawn from each of two ewe flocks, one of which had grazed on oestrogenic pastures for annual periods over the previous 5 years ("clover" treatment) while the other grazed on green oats ("oats" treatment). Fertility of ewes on the clover treatment had decreased progressively, whereas in those on the oats treatment it had remained high. Oestrous ewes were allocated alternately to receive either two or eight services then killed 24 hr post coitus and the numbers of sperm in the cervix, uterus, and fallopian tubes determined. There was no difference in ovarian activity between the two groups; however, highly significant differences were found in the numbers of sperm recovered from the cervix, uterus, and fallopian tubes. Average sperm numbers per fallopian tube were 17,160 and 350 for ewes on the oats and clover treatments respectively. In addition to the reduction in sperm numbers, both the percentage of motile sperm flushed from the cervix and the proportion of recovered ova with sperm attached to the zona pellucida were lower in ewes on the clover treatment. The results suggest that primary failure of sperm transport in ewes on the clover treatment occurred when sperm did not enter the cervix in adequate numbers following service. The significance of these observations in relation to possible causal mechanisms is discussed.

SPERM DISTRIBUTION IN FEMALE RABBITS: THE EFFECT OF OVARIAN STEROIDS

1974 ◽  
Vol 76 (4) ◽  
pp. 765-772 ◽  
Author(s):  
D. B. Morton ◽  
R. J. Fitzpatrick ◽  
T. D. Glover
Keyword(s):  
Cervix Uterus ◽  
Hormonal Treatment ◽  
The Other ◽  
Sperm Transport ◽  
Ovarian Steroids ◽  
Other Hand ◽  
Oestradiol Benzoate

ABSTRACT Oestradiol benzoate, progesterone and 20α-hydroxy-4-pregnen-3-one (20α-OH) were injected into ovariectomized rabbits and after either 4 or 5 days the rabbits were inseminated with a standardized inseminate, killed at 2 and 10 h after insemination and the number of spermatozoa in the vagina, cervix, uterus and oviducts was evaluated. The oestrogen increased the number of spermatozoa recovered from the cervix, uterus and oviduct compared with the control ovariectomized group receiving no hormonal treatment. The progestagens, on the other hand, tended to inhibit sperm transport through the cervix depending on the amount given. Injection of both oestrogen and progesterone simultaneously, illustrated their antagonistic actions. The effect of circulating progestagens on sperm transport during oestrus and pseudopregnancy is discussed, as well as their effects on the formation of the cervical reservoir.

scholarly journals IV. An account of two cases, in which ovules, or their remains, were discovered in the fallopian tubes of unimpregnated women who had died during the period of menstruation

1852 ◽  
Vol 142 ◽  
pp. 57-64 ◽  
Keyword(s):  
Fallopian Tube ◽  
Seminal Fluid ◽  
Direct Action ◽  
The Other ◽  
Fallopian Tubes ◽  
Human Female ◽  
Human Species ◽  
Graafian Follicle ◽  
The Subject ◽  
Experimental Researches

The observations that have been made at various times, during the last thirty years, by Messrs. Power, Lee, Barry, Wharton Jones, Girdwood, and others in this country, together with the experimental researches of MM. Valentin, Gendrin, Wagner, Bischoff, Pouchet and Raciborski on the Continent, have, I think, clearly proved that the phenomena manifested during the period of the catamenia in women, are closely connected with those observed during the time of heat or rut in quadrupeds; and that both of these phenomena are dependent on one cause, namely, the maturation of ovules. But while this hypothesis has been very generally admitted, there is, I believe, a tendency in the minds of many physiologists of the present day, to doubt whether the ovules so matured are ever extruded from the ovary and carried into the Fallopian tubes, without the stimulus of impregnation, or, at any rate, without the congress of the male. In support of this view, or rather of these doubts, an appeal is often made to the fact, that an ovule has never yet been detected in either of the Fallopian tubes of a virgin, who has died during the period of the catamenia, notwithstanding that many subjects have been examined, that most careful search has been instituted, and that appearances have frequently been noticed indicating the recent rupture of a Graafian follicle. In point of fact, it is imagined by those who entertain such doubts, that the fecundation of the germ takes place while it is within the Graafian follicle, and consequently, that if the ovule fails to be the subject of impregnation it never quits the ovary, but perishes within its formative vesicle. On the other hand, the researches of Bischoff have led him to enunciate a law, the purport of which is the very reverse of the preceding; for he says, that “the ovules formed in the ovaries of females of the human species and of mammiferous animals, undergo a periodical maturation, quite independently of the male seminal fluid. At these periods, known as those of heat or the rut in animals, and menstruation in the human female, the ovules which have become mature, disengage themselves from the ovary and are extruded. If the union of the sexes takes place, the ovule is fecundated by the direct action of the semen upon it. If no union of the sexes occurs, the ovule is nevertheless extruded from the ovary, and enters the Fallopian tube, but there perishes.” The law, as thus expressed, is in conformity with the opinions entertained by Drs. Robert Lee, Paterson, Girdwood, Gendrin, Pouchet, Raciborski, Mr. Wharton Jones, and many other authorities of the present time. It is also in accordance with the more ancient doctrines of Malpighi, Sir Everard Home, and Dr. Power. Nevertheless, as the truth of this law, in its application to the human female, appears to be still open to the evidence of positive proof, I have thought it desirable to publish a report of the two following cases.

scholarly journals The Fallopian Tube of the Sheep Iv. The Metabolism of Ram Spermatozoa in the Presence of Fluid from the Fallopian Tube

1966 ◽  
Vol 19 (5) ◽  
pp. 883 ◽  
Author(s):  
BJ Restall ◽  
RG Wales
Keyword(s):  
Oxygen Uptake ◽  
Fallopian Tube ◽  
Glucose Control ◽  
Glucose Utilization ◽  
The Other ◽  
Fallopian Tubes ◽  
Lactate Accumulation ◽  
Factorial Combination ◽  
Other Hand

Using isotopically labelled substrates, the metabolism of ram spermatozoa was examined in the presence of fluid from the fallopian tubes of normal ewes and spayed ewes receiving oestrogen and progesterone in factorial combination. The oxygen uptake of spermatozoa in tubal fluid was variable but was generally less than that of spermatozoa incubated in a saline diluent containing glucose (control). Due to the presence of lactate in the tubal fluids, the oxidation of added glucose by spermatozoa was consistently depressed when compared with the saline controls. On the other hand glucose utilization and lactate accumulation by spermatozoa were stimulated in the presence of tubal fluids in all experiments, the response being generally twice that of the controls. In addition, similar effects were found in fluids collected during two consecutive oestrous cycles.

scholarly journals Proportional vascularization along the fallopian tubes and ovarian fimbria: assessment by confocal microtomography

2020 ◽  
Vol 53 (3) ◽  
pp. 161-166
Author(s):  
Pedro Teixeira Castro ◽  
Osvaldo Luiz Aranda ◽  
Edson Marchiori ◽  
Luiz Felipe Bittencourt de Araújo ◽  
Haimon Diniz Lopes Alves ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Fallopian Tube ◽  
Morphometric Analysis ◽  
Room Temperature ◽  
Three Dimensional ◽  
The Other ◽  
Fallopian Tubes ◽  
Micro Ct ◽  
Iodine Staining ◽  
Important Relationship

Abstract Objective: To evaluate and reconstruct three-dimensional images of vascularization along the fallopian tube (FT), as well as to determine its relationship with the ovary and ovarian fimbria, and to quantify the blood vessels along the FT according to its anatomical segments, using confocal microtomography (micro-CT). Materials and Methods: Nine specimens (six FTs and three FTs with ovaries) were fixed in a solution of 10% formalin for > 24 h at room temperature. Iodine staining was performed by soaking the specimens in 10% Lugol’s solution for 24 h. All specimens were evaluated using micro-CT. A morphometric analysis was performed on the reconstructed images to quantify the vascular distribution along the FT. Results: In the FTs evaluated, the density of blood vessels was significantly greater in the fimbrial segments than in the isthmic segments (p < 0.05). The ovarian fimbria was clearly identified, demonstrating the important relationship between these vessels and the FT fimbriae. Conclusion: We believe that the vascularization in the fimbriae is greater than and disproportional that in the other segments of FT, and that the ovarian fimbria plays an important role in the development of that difference.

scholarly journals The Fallopian Tube of the Sheep. V. Secretion From the Ampullla and Isthmus

1968 ◽  
Vol 21 (3) ◽  
pp. 491 ◽  
Author(s):  
BJ Restall ◽  
RG Wales
Keyword(s):  
Fallopian Tube ◽  
Luteal Phase ◽  
The Other ◽  
Fallopian Tubes

The fallopian tubes of four ewes were cannulated so that secretions collected from the isthmus and ampulla of one side could be compared with the secretion from the other entire fallopian tube. Maximum fluid output from all sites occurred at oestrus and was least during the luteal phase of the cycle. Secretion from the ampulla was generally twice that from the isthmus.

scholarly journals On the Value of rectal exploration as an Aid to Diagnosis in Diseases of children. Tuberculosis of the Uterus or Adnexa

2020 ◽  
Vol 11 (3) ◽  
pp. 347-348
Author(s):  
M. Ginzburg
Keyword(s):  
Fallopian Tube ◽  
The Other ◽  
Pelvic Cavity ◽  
Fallopian Tubes ◽  
The Brain

Tuberculosis of the uterus, Fallopian tubes, and ovaries very rare in children, so rare that D-r. S. remembers all these cases both clinical and postmortem. There are also very few of these drugs in museums. In Guy's Hospital, there are only 2 of them: one is the Fallopian tube, stretched by cheese-like masses, the other is the brain and lungs. Choffey reported one case of uterine tuberculosis in a 4-year-old girl who died of general tuberculosis; Silcock in a 5-year-old girl, both in 1885, Dr Cheatle at an autopsy of a 21-month-old girl, found pyosalpinx communicating with a purulent pelvic cavity, where there was pus near the drachm.

Global Economic Crisis of 2008-2009: Sources and Roots

2009 ◽  
pp. 18-31
Author(s):  
G. Rapoport ◽  
A. Guerts
Keyword(s):  
Oil And Gas ◽  
Trade Deficit ◽  
Developed Countries ◽  
The Other ◽  
Energy Resources ◽  
Market Mechanisms ◽  
Production Output ◽  
The One ◽  
To Receive ◽  
Partial Destruction

In the article the global crisis of 2008-2009 is considered as superposition of a few regional crises that occurred simultaneously but for different reasons. However, they have something in common: developed countries tend to maintain a strong level of social security without increasing the real production output. On the one hand, this policy has resulted in trade deficit and partial destruction of market mechanisms. On the other hand, it has clashed with the desire of several oil and gas exporting countries to receive an exclusive price for their energy resources.

Reproductive characteristics of the african pygmy hedgehog, atelerix albiventris

Reproduction ◽  
2000 ◽  
pp. 143-150 ◽  
Author(s):  
JM Bedford ◽  
OB Mock ◽  
SK Nagdas ◽  
VP Winfrey ◽  
GE Olson
Keyword(s):  
Fallopian Tube ◽  
Zona Pellucida ◽  
Sperm Head ◽  
Reproductive Characteristics ◽  
Cumulus Oophorus ◽  
The Matrix ◽  
Main Components ◽  
Initial Binding ◽  
Structural Matrix

To obtain further perspective on reproduction and particularly gamete function among so-called primitive mammals presently grouped in the Order Insectivora, we have examined the African hedgehog, Atelerix albiventris, in light of unusual features reported in shrews and moles. Atelerix proves to share many but not all of the characteristics seen in these other insectivores. The penis of Atelerix has a 'snail-like' form, but lacks the surface spines common in insectivores and a number of other mammals. Hedgehog spermatozoa display an eccentric insertion of the tail on the sperm head, and they manifest the barbs on the perforatorium that, in shrews, probably effect the initial binding of the sperm head to the zona pellucida. As a possible correlate, the structural matrix of the hedgehog acrosome comprises only two main components, as judged by immunoblotting, rather than the complex of peptides seen in the matrix of some higher mammals. The Fallopian tube of Atelerix is relatively simple; it displays only minor differences in width and in the arborized epithelium between the isthmus and ampulla, and shows no evidence of the unusual sperm crypts that characterize the isthmus or ampulla, depending on the species, in shrews and moles. In common with other insectivores, Atelerix appears to be an induced ovulator, as judged by the ovulation of some 6-8 eggs by about 23 h after injection of hCG. The dense cumulus oophorus appeared to have little matrix, in keeping with the modest dimensions of the tubal ampulla and, while it was not quite as discrete as that of soricids, it did show the same insensitivity to 0.5% (w/v) ovine or bovine hyaluronidase.

VP39 The Alphabet Lottery? How NICE Outcomes Vary By Appraisal Committee

2019 ◽  
Vol 35 (S1) ◽  
pp. 86-86
Author(s):  
Richard Macaulay ◽  
Lok Wan Liu ◽  
Cornelia Roibu ◽  
Andrea Berardi
Keyword(s):  
Cost Effectiveness ◽  
The Other ◽  
Appraisal Committee ◽  
Technology Appraisal ◽  
The Public ◽  
Chi Squared ◽  
C 50 ◽  
To Receive ◽  
Disciplinary Group ◽  
53 C 55

IntroductionNICE (National Institute for Health and Care Excellence) makes recommendations on the public reimbursement of medicines based on their clinical- and cost-effectiveness. The recommendation is made by an Appraisal Committee (comprising a multi-disciplinary group of independent experts) as part of a technology appraisal. There are four Appraisal Committees (A,B,C,D); this research investigates whether appraisal outcomes vary by committee.MethodsAll publicly-available Final Appraisal Determinations from NICE Single Technology Appraisals (STA) were screened (01/10/2009-14/11/2018) and key data were extracted. Homogeneity in rates of acceptance or rejection across the committees was assessed using Chi-squared tests.ResultsThe Appraisal Committee was identified for 298 technologies, 56% (168/298) of which were ‘recommended’. The number of technologies assessed by each committee was similar (A:79, B:62, C:91, D:66). However, STAs conducted by Committee D were significantly less likely to receive ‘recommended’ outcomes (A:68% [54/79], B:65% [40/62], C:53% [48/91], D:39% [26/66]; p < 0.01). STAs for oncology indications had higher ’not recommended’ outcomes than those for non-oncology indications (25% vs. 9%). The lower ‘recommendation’ rates for committee D persisted across oncology (A:60%, B:83%, C:50%, D:38%; p = 0.01) and non-oncology indications (A:73%, B:53%, C:55%, D:40%; p < 0.01). However, STAs conducted by Committee D were significantly more likely to receive ‘optimized’ recommendations (A:16%, B:21%, C:33%, D: 36%; p < 0.01) and when considering the rates of ‘recommended’ and ‘optimized’ outcomes compared to ‘only in research’ and ‘not recommended’ outcomes, no significant differences were found (A:85%, B: 85%, C:86%, D:76%; p = 0.27).ConclusionsSTAs undertaken by NICE Appraisal Committee D was associated with a significantly lower rate of ‘recommended’ outcomes but tended to an ‘optimized’ recommendation significantly more than the other committees. Further research is needed to determine if this reflects any deviation in uniform implementation of NICE methodology between Committees.

The Absence and Influence of Genesis 48 (the Blessing of Ephraim and Manasseh) in the Book of Jubilees

2017 ◽  
Vol 26 (4) ◽  
pp. 255-273
Author(s):  
Pauline P. Buisch
Keyword(s):  
The Other ◽  
Literary Influence ◽  
To Receive

While scholars have acknowledged the literary dependence of Jubilees 31 (the blessing of Levi and Judah) on Genesis 48 (the blessing of Ephraim and Manasseh), little work has been done to understand the purpose of this intentional intertextuality. This article examines the literary influence of Genesis 48, the effect of its absence, and the altered roles of Levi, Judah, and Joseph in Jubilees in order to determine why the author made the literary decision to pattern one scene of blessing after the other. This article suggests that the author's decision to omit Genesis 48 and to present not one but two similar scenes of blessing in its place is part of a larger strategy to negotiate the interpretive problem of the prominent status given to Joseph's sons in Genesis 48. By replacing Ephraim and Manasseh with Levi and Judah, but allowing Joseph to receive the double portion of land, the author of Jubilees reflects an interpretive tradition, also found in the Targums, Genesis Rabbah, and the Testaments of the Patriarchs, that understands the inheritance of Jacob to be threefold and distributed three ways—the birthright to Joseph, the priesthood to Levi, and the kingship to Judah.

Sign in / Sign up

Export Citation Format

Share Document