Flavonoid intermediates for the synthesis of mopanol trimethyl ether[trans-trans-7,7',8'-Trimethoxyisochromano(4',3':2,3)chroman-4-ol]
Keyword(s):
Preparation of a number of intermediates for the synthesis of (�)-mopanol trimethyl ether is described, together with exploratory reactions with model compounds, and especially with 7-methoxyflavanone-2'-carboxylic acid. 7-Methoxyflavan-4-ol, the initial product from reduction of 7-methoxyflavanone-2'-carboxylic acid with complex metal hydrides, was found to undergo facile dehydration to a novel intramolecular dibenzyl ether [the cyclic ether (19)*]. It was noted that the methoxymethyl group, which may be used as a protecting group for phenols, did not survive the conditions of methylation with dimethyl sulphate and potassium carbonate in acetone.
Keyword(s):
1973 ◽
Vol 51
(13)
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pp. 2092-2097
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2006 ◽
Vol 47
(22)
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pp. 3629-3631
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2015 ◽
Vol 22
(3)
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pp. 902-906
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