Molecular determinants of PI3K -mediated activation downstream of G-protein-coupled receptors (GPCRs)

O. Vadas; H. A. Dbouk; A. Shymanets; O. Perisic; J. E. Burke; W. F. Abi Saab; B. D. Khalil; C. Harteneck; A. R. Bresnick; B. Nurnberg; J. M. Backer; R. L. Williams

doi:10.1073/pnas.1304801110

Molecular determinants of PI3K -mediated activation downstream of G-protein-coupled receptors (GPCRs)

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1304801110 ◽

2013 ◽

Vol 110 (47) ◽

pp. 18862-18867 ◽

Cited By ~ 71

Author(s):

O. Vadas ◽

H. A. Dbouk ◽

A. Shymanets ◽

O. Perisic ◽

J. E. Burke ◽

...

Keyword(s):

G Protein ◽

G Protein Coupled Receptors ◽

Molecular Determinants ◽

G Protein Coupled

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Biased signaling of G protein coupled receptors (GPCRs): Molecular determinants of GPCR/transducer selectivity and therapeutic potential

Pharmacology & Therapeutics ◽

10.1016/j.pharmthera.2019.05.006 ◽

2019 ◽

Vol 200 ◽

pp. 148-178 ◽

Cited By ~ 21

Author(s):

Mohammad Seyedabadi ◽

Mohammad Hossein Ghahremani ◽

Paul R. Albert

Keyword(s):

G Protein ◽

Therapeutic Potential ◽

G Protein Coupled Receptors ◽

Molecular Determinants ◽

Biased Signaling ◽

G Protein Coupled

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Molecular Determinants and Kinetic Parameters of Ligand Binding to G Protein-Coupled Receptors using Markov State Model Analysis

Biophysical Journal ◽

10.1016/j.bpj.2014.11.558 ◽

2015 ◽

Vol 108 (2) ◽

pp. 97a

Author(s):

Sebastian Schneider ◽

Davide Provasi ◽

Marta Filizola

Keyword(s):

Ligand Binding ◽

Kinetic Parameters ◽

G Protein ◽

Model Analysis ◽

G Protein Coupled Receptors ◽

State Model ◽

Markov State Model ◽

Markov State ◽

Molecular Determinants ◽

G Protein Coupled

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Molecular determinants of the mechanosensitivity of G protein‐coupled receptors

The FASEB Journal ◽

10.1096/fasebj.2020.34.s1.05324 ◽

2020 ◽

Vol 34 (S1) ◽

pp. 1-1

Author(s):

Michael Mederos y Schnitzler ◽

Ursula Storch ◽

Serap Erdogmus ◽

Laura Danner ◽

Jasmin Becker ◽

...

Keyword(s):

G Protein ◽

G Protein Coupled Receptors ◽

Molecular Determinants ◽

G Protein Coupled

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A combination of machine learning and infrequent metadynamics to efficiently predict kinetic rates, transition states, and molecular determinants of drug dissociation from G protein-coupled receptors

The Journal of Chemical Physics ◽

10.1063/5.0019100 ◽

2020 ◽

Vol 153 (12) ◽

pp. 124105

Author(s):

João Marcelo Lamim Ribeiro ◽

Davide Provasi ◽

Marta Filizola

Keyword(s):

Machine Learning ◽

G Protein ◽

Transition States ◽

G Protein Coupled Receptors ◽

Kinetic Rates ◽

Molecular Determinants ◽

G Protein Coupled

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Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors

10.1016/s1877-1173(20)x0002-0 ◽

2020 ◽

Keyword(s):

G Protein ◽

G Protein Coupled Receptors ◽

Health And Disease ◽

G Protein Coupled

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G Protein-Coupled Receptors Part A

10.1016/s0091-679x(17)x0006-x ◽

2017 ◽

Keyword(s):

G Protein ◽

G Protein Coupled Receptors ◽

G Protein Coupled

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G Protein-Coupled Receptors - Signaling, Trafficking and Regulation

10.1016/s0091-679x(16)x0002-7 ◽

2016 ◽

Keyword(s):

G Protein ◽

G Protein Coupled Receptors ◽

G Protein Coupled

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Enhanced Salmonella virulence instigated by bactivorous protozoa and investigation of putative protozoan G protein-coupled receptors associated with bacterial engulfment

10.31274/etd-180810-61 ◽

2014 ◽

Author(s):

Matt T. Brewer

Keyword(s):

G Protein ◽

G Protein Coupled Receptors ◽

Salmonella Virulence ◽

G Protein Coupled

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Faculty Opinions recommendation of Modulation of postendocytic sorting of G protein-coupled receptors.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1008239.104108 ◽

2002 ◽

Author(s):

Silvia Arber

Keyword(s):

G Protein ◽

G Protein Coupled Receptors ◽

G Protein Coupled

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Faculty Opinions recommendation of Proteochemometrics modeling of the interaction of amine G-protein coupled receptors with a diverse set of ligands.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1007831.98556 ◽

2002 ◽

Author(s):

Wolfgang Guba

Keyword(s):

G Protein ◽

G Protein Coupled Receptors ◽

G Protein Coupled

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