Extracellular matrix fibronectin increases prostaglandin E2receptor subtype EP4 in lung carcinoma cells through multiple signaling pathways.THE ROLE OF AP-2.

Long noncoding RNAs (lncRNAs) play a critical role in the development of lung carcinoma. The mechanism of MALAT1 in lung carcinoma development is not understood very well. This study aimed to investigate the role of MALAT1 in lung carcinoma progression and the mechanism underlying the role of miR-491-5p in the MALAT1 mediated regulation of UBE2C expression. The results indicated that the expression of MALAT1 was often augmented in lung carcinoma cells. Suppression of MALAT1 blocked the proliferation, invasion and migration ability of cancer cells and inhibited the expression of UBE2C. UBE2C restoration attenuated the MALAT1 knockdown-induced anti-cancer effects. Moreover, UBE2C and MALAT1 were indicated as targets of miR-491-5p and inhibition of miR-491-5p restored the MALAT1 knockdown-induced inhibition of the progression of lung carcinoma. Furthermore, MALAT1 sponged miR-491-5p to upregulate UBE2C expression, causing it to act as a competing endogenous RNA. Collectively, MALAT1 downregulation suppressed lung carcinoma progression by regulating the miR-491-5p/UBE2C axis. These results indicate that MALAT1 could be a molecular target for lung carcinoma treatment and prognosis.

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Role of p53 and p38 MAP kinase in nitric oxide-induced G2/M arrest and apoptosis in the human lung carcinoma cells

Carcinogenesis ◽

10.1093/carcin/bgg155 ◽

2003 ◽

Author(s):

J.-I Chao

Keyword(s):

Nitric Oxide ◽

Map Kinase ◽

Lung Carcinoma ◽

Human Lung ◽

P38 Map Kinase ◽

Carcinoma Cells ◽

Lung Carcinoma Cells ◽

Human Lung Carcinoma

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The role of cytochrome c oxidase subunit Va in non-small cell lung carcinoma cells: association with migration, invasion and prediction of distant metastasis

BMC Cancer ◽

10.1186/1471-2407-12-273 ◽

2012 ◽

Vol 12 (1) ◽

Cited By ~ 27

Author(s):

Wen-Liang Chen ◽

Kuang-Tai Kuo ◽

Teh-Ying Chou ◽

Chien-Lung Chen ◽

Chih-Hao Wang ◽

...

Keyword(s):

Cytochrome C Oxidase ◽

Lung Carcinoma ◽

Distant Metastasis ◽

Small Cell Lung Carcinoma ◽

Small Cell ◽

Carcinoma Cells ◽

Small Cell Lung ◽

Cell Lung Carcinoma ◽

Lung Carcinoma Cells

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Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface.

The Journal of Cell Biology ◽

10.1083/jcb.113.4.919 ◽

1991 ◽

Vol 113 (4) ◽

pp. 919-929 ◽

Cited By ~ 221

Author(s):

E A Wayner ◽

R A Orlando ◽

D A Cheresh

Keyword(s):

Cell Surface ◽

Lung Carcinoma ◽

Cell Attachment ◽

Cell Types ◽

Carcinoma Cells ◽

Lung Carcinoma Cells ◽

Distinct Cell ◽

Contact Distribution ◽

Alpha V Beta 3

We investigated the role of the integrins alpha v beta 3 and alpha v beta 5 in mediating vitronectin adhesion of three phenotypically distinct cell types. M21 human melanoma cells and H2981 lung carcinoma cells use both alpha v-containing integrins in adhering to vitronectin while UCLA-P3 lung carcinoma cells adhere exclusively with alpha v beta 5. Specifically, monoclonal antibodies directed to functional epitopes on both receptors were required to block adhesion of M21 or H2981 cells while adhesion of UCLA-P3 cells to vitronectin could be blocked with a monoclonal antibody to alpha v beta 5. Although both receptors are involved in M21 and H2981 cell adhesion to vitronectin, only alpha v beta 3 can be detected in focal contacts, colocalizing with vinculin, talin, and the ends of actin filaments, while alpha v beta 5 shows a distinct, nonfocal contact, distribution on the cell surface. These results provide the first evidence that two homologous integrins that recognize the same ligand distribute differentially on the cell surface.

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