scholarly journals The Angiogenic Factors Cyr61 and Connective Tissue Growth Factor Induce Adhesive Signaling in Primary Human Skin Fibroblasts

2000 ◽  
Vol 276 (13) ◽  
pp. 10443-10452 ◽  
Author(s):  
Chih-Chiun Chen ◽  
Ningyu Chen ◽  
Lester F. Lau
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Human Skin ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth ◽  
Angiogenic Factors ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts

scholarly journals Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair.

1993 ◽  
Vol 4 (6) ◽  
pp. 637-645 ◽  
Author(s):  
A Igarashi ◽  
H Okochi ◽  
D M Bradham ◽  
G R Grotendorst
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Connective Tissue ◽  
Human Skin ◽  
Connective Tissue Growth Factor ◽  
Wound Repair ◽  
Tissue Growth ◽  
Skin Fibroblasts ◽  
Tgf Beta ◽  
Human Skin Fibroblasts

Connective tissue growth factor (CTGF) is a cysteine-rich peptide that exhibits platelet-derived growth factor (PDGF)-like biological and immunological activities. CTGF is a member of a family of peptides that include serum-induced immediate early gene products, a v-src-induced peptide, and a putative avian transforming gene, nov. In the present study, we demonstrate that human foreskin fibroblasts produce high levels of CTGF mRNA and protein after activation with transforming growth factor beta (TGF-beta) but not other growth factors including PDGF, epidermal growth factor, and basic fibroblast growth factor. Because of the high level selective induction of CTGF by TGF-beta, it appears that CTGF is a major autocrine growth factor produced by TGF-beta-treated human skin fibroblasts. Cycloheximide did not block the large TGF-beta stimulation of CTGF gene expression, indicating that it is directly regulated by TGF-beta. Similar regulatory mechanisms appear to function in vivo during wound repair where there is a coordinate expression of TGF-beta 1 before CTGF in regenerating tissue, suggesting a cascade process for control of tissue regeneration and repair.

scholarly journals Could Aging Human Skin Use a Connective Tissue Growth Factor Boost to Increase Collagen Content?

2010 ◽  
Vol 130 (2) ◽  
pp. 338-341 ◽  
Author(s):  
Noelynn Oliver ◽  
Mark Sternlicht ◽  
Karin Gerritsen ◽  
Roel Goldschmeding
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Human Skin ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth ◽  
Collagen Content

scholarly journals Reduced Expression of Connective Tissue Growth Factor (CTGF/CCN2) Mediates Collagen Loss in Chronologically Aged Human Skin

2010 ◽  
Vol 130 (2) ◽  
pp. 415-424 ◽  
Author(s):  
TaiHao Quan ◽  
Yuan Shao ◽  
Tianyuan He ◽  
John J. Voorhees ◽  
Gary J. Fisher
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Human Skin ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth

scholarly journals Hypoxia induces expression of connective tissue growth factor in scleroderma skin fibroblasts

2006 ◽  
Vol 146 (2) ◽  
pp. 362-370 ◽  
Author(s):  
K.-H. Hong ◽  
S.-A. Yoo ◽  
S.-S. Kang ◽  
J.-J. Choi ◽  
W.-U. Kim ◽  
...  
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth ◽  
Skin Fibroblasts
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