scholarly journals Roles of the C Termini of α-, β-, and γ-Subunits of Epithelial Na+Channels (ENaC) in Regulating ENaC and Mediating Its Inhibition by Cytosolic Na+

2001 ◽  
Vol 276 (17) ◽  
pp. 13744-13749 ◽  
Author(s):  
Anuwat Dinudom ◽  
Kieran F. Harvey ◽  
Permsak Komwatana ◽  
Corina N. Jolliffe ◽  
John A. Young ◽  
...  
Keyword(s):  
Na Channels ◽  
Epithelial Na Channels

Mechanisms and sequelae of increased alveolar fluid clearance in hyperoxic rats

1997 ◽  
Vol 272 (3) ◽  
pp. L407-L412 ◽  
Author(s):  
G. Yue ◽  
S. Matalon
Keyword(s):  
Alveolar Epithelial Cells ◽  
Na Channels ◽  
Alveolar Fluid Clearance ◽  
Na Transport ◽  
Alveolar Epithelial ◽  
Lung Fluid ◽  
Isotonic Fluid ◽  
Epithelial Na Channels ◽  
Alveolar Edema

We instilled 4 ml isotonic fluid containing trace amounts of fluorescently labeled dextran (molecular mass 150 kDa) in the lungs of rats exposed to either 85% O(2) for 7 days or to 85% O(2) for 7 days and 100% O(2) for 3 days. We withdrew the fluid every hour for a 3-h period and calculated alveolar fluid clearance (AFC) from changes in dextran concentration. Postinstillation (3 h), AFC values in the control and the two hyperoxic groups were 51 +/- 1, 63 +/- 2, and 62 +/- 3 (SE), respectively (%instilled volume; n > or = 5; P < 0.05). Addition of either 1 mM amiloride or N-ethyl-N-isopropyl amiloride (EIPA) in the instillate decreased the AFC values in all groups 3 h later to approximately 30% of instilled volume. Instillation of phenamil, an irreversible blocker of epithelial Na+ channels into the lungs of rats exposed to 85% O(2) for 7 days and 100% O(2) for 2 days, resulted in a significant increase of their extravascular lung fluid volumes 24 h later. These results demonstrate the existence of EIPA-inhibitable Na+ channels in alveolar epithelial cells in vivo and indicate that an increase in Na+ transport plays an important role in limiting the amount of alveolar edema in O(2)-damaged lungs.

scholarly journals Side Chain Orientation of Residues Lining the Selectivity Filter of Epithelial Na+Channels

2004 ◽  
Vol 280 (9) ◽  
pp. 8513-8522 ◽  
Author(s):  
Shaohu Sheng ◽  
Clint J. Perry ◽  
Ossama B. Kashlan ◽  
Thomas R. Kleyman
Keyword(s):  
Selectivity Filter ◽  
Side Chain ◽  
Na Channels ◽  
Chain Orientation ◽  
Epithelial Na Channels ◽  
Side Chain Orientation

Blockade of epithelial Na+ channels by triamterenes — Underlying mechanisms and molecular basis

1996 ◽  
Vol 432 (5) ◽  
pp. 760-766 ◽  
Author(s):  
A. E. Busch ◽  
H. Suessbrich ◽  
K. Kunzelmann ◽  
A. Hipper ◽  
R. Greger ◽  
...  
Keyword(s):  
Molecular Basis ◽  
Na Channels ◽  
Epithelial Na Channels ◽  
Underlying Mechanisms

scholarly journals Na restriction activates epithelial Na channels in rat kidney through two mechanisms and decreases distal Na+ delivery

2018 ◽  
Vol 596 (16) ◽  
pp. 3585-3602 ◽  
Author(s):  
Gustavo Frindt ◽  
Lei Yang ◽  
Krister Bamberg ◽  
Lawrence G. Palmer
Keyword(s):  
Rat Kidney ◽  
Na Channels ◽  
Epithelial Na Channels

Epithelial Na Channels and Their Kin

Physiology ◽  
1995 ◽  
Vol 10 (2) ◽  
pp. 61-67 ◽  
Author(s):  
LG Palmer
Keyword(s):  
Na Channels ◽  
Epithelial Na Channels ◽  
Mechanical Sensing ◽  
Stretch Activated Channels

Epithelial Na channels help maintain Na homeostasis by controlling the rate of Na absorption by the kidney and other organs. Surprisingly, they show homology with genes involved in mechanical sensing and transduction. This suggests that epithelial Na channels and stretch-activated channels may be in the same family.

Synthesis and characterization of methylbromoamiloride, a potential biochemical probe of epithelial Na+ channels

1985 ◽  
Vol 86 (1) ◽  
pp. 69-77 ◽  
Author(s):  
Kathy Lazorick ◽  
Christopher Miller ◽  
Sarah Sariban-Sohraby ◽  
Dale Benos
Keyword(s):  
Synthesis And Characterization ◽  
Na Channels ◽  
Epithelial Na Channels

scholarly journals Peptide Inhibition of Constitutively Activated Epithelial Na+Channels Expressed inXenopusOocytes

1999 ◽  
Vol 274 (53) ◽  
pp. 37693-37704 ◽  
Author(s):  
Hong-Long Ji ◽  
Catherine M. Fuller ◽  
Dale J. Benos
Keyword(s):  
Na Channels ◽  
Epithelial Na Channels ◽  
Peptide Inhibition

scholarly journals Extracellular Zn2+Activates Epithelial Na+Channels by Eliminating Na+Self-inhibition

2004 ◽  
Vol 279 (30) ◽  
pp. 31687-31696 ◽  
Author(s):  
Shaohu Sheng ◽  
Clint J. Perry ◽  
Thomas R. Kleyman
Keyword(s):  
Na Channels ◽  
Epithelial Na Channels
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