scholarly journals Single Amino Acid Alteration between Valine and Isoleucine Determines the Distinct Pyrabactin Selectivity by PYL1 and PYL2

2010 ◽  
Vol 285 (37) ◽  
pp. 28953-28958 ◽  
Author(s):  
Xiaoqiu Yuan ◽  
Ping Yin ◽  
Qi Hao ◽  
Chuangye Yan ◽  
Jiawei Wang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Single Amino Acid ◽  
Acid Alteration ◽  
Amino Acid Alteration

scholarly journals A Single Amino Acid Alteration in PGR5 Confers Resistance to Antimycin A in Cyclic Electron Transport around PSI

2013 ◽  
Vol 54 (9) ◽  
pp. 1525-1534 ◽  
Author(s):  
Kazuhiko Sugimoto ◽  
Yuki Okegawa ◽  
Akihiko Tohri ◽  
Terri A. Long ◽  
Sarah F. Covert ◽  
...  
Keyword(s):  
Amino Acid ◽  
Electron Transport ◽  
Single Amino Acid ◽  
Antimycin A ◽  
Cyclic Electron Transport ◽  
Acid Alteration ◽  
Amino Acid Alteration

scholarly journals A Single Amino Acid Alteration in the Human Parainfluenza Virus Type 3 Hemagglutinin-Neuraminidase Glycoprotein Confers Resistance to the Inhibitory Effects of Zanamivir on Receptor Binding and Neuraminidase Activity

2001 ◽  
Vol 75 (14) ◽  
pp. 6310-6320 ◽  
Author(s):  
Matthew T. Murrell ◽  
Matteo Porotto ◽  
Olga Greengard ◽  
Natalia Poltoratskaia ◽  
Anne Moscona
Keyword(s):  
Sialic Acid ◽  
Amino Acid ◽  
Virus Type ◽  
Parainfluenza Virus ◽  
Single Amino Acid ◽  
Plaque Morphology ◽  
Human Parainfluenza Virus ◽  
Type 3 ◽  
Acid Alteration ◽  
Amino Acid Alteration

ABSTRACT Entry and fusion of human parainfluenza virus type 3 (HPF3) requires interaction of the viral hemagglutinin-neuraminidase (HN) glycoprotein with its sialic acid receptor. 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid (4-GU-DANA; zanamivir), a sialic acid transition-state analog designed to fit the influenza virus neuraminidase catalytic site, possesses antiviral activity at nanomolar concentrations in vitro. We have shown previously that 4-GU-DANA also inhibits both HN-mediated binding of HPF3 to host cell receptors and HN's neuraminidase activity. In the present study, a 4-GU-DANA-resistant HPF3 virus variant (ZM1) was generated by serial passage in the presence of 4-GU-DANA. ZM1 exhibited a markedly fusogenic plaque morphology and harbored two HN gene mutations resulting in two amino acid alterations, T193I and I567V. Another HPF3 variant studied in parallel, C-0, shared an alteration at T193 and exhibited similar plaque morphology but was not resistant to 4-GU-DANA. Neuraminidase assays revealed a 15-fold reduction in 4-GU-DANA sensitivity for ZM1 relative to the wild type (WT) and C-0. The ability of ZM1 to bind sialic acid receptors was inhibited 10-fold less than for both WT and C-0 in the presence of 1 mM 4-GU-DANA. ZM1 also retained infectivity at 15-fold-higher concentrations of 4-GU-DANA than WT and C-0. A single amino acid alteration at HN residue 567 confers these 4-GU-DANA-resistant properties. An understanding of ZM1 and other escape variants provides insight into the effects of this small molecule on HN function as well as the role of the HN glycoprotein in HPF3 pathogenesis.

A single amino acid alteration in murine PrP dramatically alters TSE incubation time

2000 ◽  
pp. 95-102 ◽  
Author(s):  
J. C. Manson ◽  
R. Barron ◽  
E. Jamieson ◽  
H. Baybutt ◽  
N. Tuzi ◽  
...  
Keyword(s):  
Amino Acid ◽  
Incubation Time ◽  
Single Amino Acid ◽  
Acid Alteration ◽  
Amino Acid Alteration

scholarly journals Impaired Transporter Associated with Antigen Processing (TAP) Function Attributable to a Single Amino Acid Alteration in the Peptide TAP Subunit TAP1

2003 ◽  
Vol 170 (2) ◽  
pp. 941-946 ◽  
Author(s):  
Ulrike Ritz ◽  
Ingo Drexler ◽  
Dirk Sutter ◽  
Rupert Abele ◽  
Christoph Huber ◽  
...  
Keyword(s):  
Amino Acid ◽  
Antigen Processing ◽  
Single Amino Acid ◽  
Acid Alteration ◽  
Amino Acid Alteration

scholarly journals Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration

Aging ◽  
2014 ◽  
Vol 6 (5) ◽  
pp. 390-398 ◽  
Author(s):  
Sahar Emran ◽  
Mingyao Yang ◽  
Xiaoli He ◽  
Jelle Zandveld ◽  
Matthew D. W. Piper
Keyword(s):  
Amino Acid ◽  
Dietary Restriction ◽  
Essential Amino Acid ◽  
Target Of Rapamycin ◽  
Acid Alteration ◽  
Amino Acid Alteration
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