scholarly journals Role of ADP-ribosylation Factor 6 (ARF6) in Gastric Acid Secretion

2003 ◽  
Vol 278 (38) ◽  
pp. 36470-36475 ◽  
Author(s):  
Jun Matsukawa ◽  
Kazuhisa Nakayama ◽  
Taku Nagao ◽  
Hidenori Ichijo ◽  
Tetsuro Urushidani
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Adp Ribosylation ◽  
Adp Ribosylation Factor

scholarly journals Functional Role of Protein Kinase B/Akt in Gastric Acid Secretion

2001 ◽  
Vol 276 (49) ◽  
pp. 46436-46444 ◽  
Author(s):  
Andrea Todisco ◽  
Nonthalee Pausawasdi ◽  
Saravanan Ramamoorthy ◽  
John Del Valle ◽  
Rebecca W. Van Dyke ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Functional Role ◽  
Protein Kinase B

50 - Reflux Esophagitis after Helicobacter Pylori Eradication: The Role of Gastric Acid Secretion

2018 ◽  
Vol 154 (6) ◽  
pp. S-17
Author(s):  
Francesco Di Mario ◽  
Serena Scida ◽  
Marilisa Franceschi ◽  
Chiara Miraglia ◽  
Kryssia Rodriguez ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Reflux Esophagitis ◽  
Helicobacter Pylori Eradication

PACAP stimulates gastric acid secretion in the rat by inducing histamine release

2001 ◽  
Vol 281 (4) ◽  
pp. G997-G1003 ◽  
Author(s):  
Arne K. Sandvik ◽  
Guanglin Cui ◽  
Ingunn Bakke ◽  
Bjørn Munkvold ◽  
Helge L. Waldum
Keyword(s):  
Acid Secretion ◽  
Histamine Release ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Rat Stomach ◽  
Neurohumoral Regulation ◽  
Ecl Cell ◽  
Pituitary Adenylate Cyclase ◽  
Awake Rat

Previous studies have shown that pituitary adenylate cyclase-activating peptide (PACAP) stimulates enterochromaffin-like (ECL) cell histamine release, but its role in the regulation of gastric acid secretion is disputed. This work examines the effect of PACAP-38 on aminopyrine uptake in enriched rat parietal cells and on histamine release and acid secretion in the isolated vascularly perfused rat stomach and the role of PACAP in vagally (2-deoxyglucose) stimulated acid secretion in the awake rat. PACAP has no direct effect on the isolated parietal cell as assessed by aminopyrine uptake. PACAP induces a concentration-dependent histamine release and acid secretion in the isolated stomach, and its effect on histamine release is additive to gastrin. The histamine H2antagonist ranitidine potently inhibits PACAP-stimulated acid secretion without affecting histamine release. Vagally stimulated acid secretion is partially inhibited by a PACAP antagonist. The results from the present study strongly suggest that PACAP plays an important role in the neurohumoral regulation of gastric acid secretion. Its effect seems to be mediated by the release of ECL cell histamine.

Role of gastric acid secretion in progression of acute gastric erosions induced by ischemia–reperfusion into gastric ulcers

2000 ◽  
Vol 398 (1) ◽  
pp. 147-158 ◽  
Author(s):  
Tomasz Brzozowski ◽  
Peter Ch Konturek ◽  
Stanislaw J Konturek ◽  
Danuta Drozdowicz ◽  
Slawomir Kwiecieñ ◽  
...  
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Ischemia Reperfusion ◽  
Gastric Ulcers ◽  
Gastric Erosions

Role of gastric acid secretion and blood flow in the development of vagal stimulation induced gastric mucosal damage

1993 ◽  
Vol 71 (10-11) ◽  
pp. 829-834 ◽  
Author(s):  
Lynn E. Hierlihy ◽  
John L. Wallace ◽  
Alastair V. Ferguson
Keyword(s):  
Blood Flow ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Vagal Stimulation ◽  
Mucosal Damage ◽  
Secretory Rate ◽  
The Mean ◽  
Gastric Mucosal Erosions

Vagal stimulation has been shown to result in the development of gastric mucosal erosions in the rat, although the mechanisms underlying the development of such erosions are not known. The effects of vagal stimulation on gastric acid secretion and mucosal blood flow were examined in urethane-anesthetized male Sprague–Dawley rats to determine whether changes in these factors correlate with the mucosal damage in response to vagal stimulation. Electrical stimulation (5 Hz, 5 V, 1 ms for 60 min) of afferent or efferent components of the vagi was not found to induce any significant increase in the mean acid secretory rate compared with control animals (p > 0.05). In contrast, stimulation of intact vagus nerves induced a significant increase in the mean acid secretory rate compared with control and efferent- and afferent-stimulated groups (p < 0.01). Measurement of gastric blood flow with laser-Doppler flowmetry demonstrated intact vagal stimulation to have no significant effect on gastric blood flow. These data suggest that such vagal stimulation induced increases in acid secretion in urethane-anesthetized animals may represent a part of the integrated physiological response to such stimulation which leads to the development of gastric mucosal erosions within 60 min. Pretreatment with antisecretory agents such as cimetidine and inter-leukin-1β significantly reduce the gastric mucosal injury compared with untreated animals (p < 0.05), emphasizing the important role of acid secretion in the development of vagal-induced gastric damage.Key words: vagus, acid secretion, blood flow, gastric.

Lipopolysacchardide (LPS) induced inhibition of gastric acid secretion: Role of H/K-ATPase

2001 ◽  
Vol 120 (5) ◽  
pp. A156-A157 ◽  
Author(s):  
Kenneth Helmer ◽  
Ronald Vilela ◽  
Bruce C. Kone ◽  
David W. Mercer
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid
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