Tailoringin VitroSelection for a Picomolar Affinity Human Antibody Directed against Vascular Endothelial Growth Factor Receptor 2 for Enhanced Neutralizing Activity

Dan Lu; Juqun Shen; Marie D. Vil; Haifan Zhang; Xenia Jimenez; Peter Bohlen; Larry Witte; Zhenping Zhu

doi:10.1074/jbc.m307742200

Tailoringin VitroSelection for a Picomolar Affinity Human Antibody Directed against Vascular Endothelial Growth Factor Receptor 2 for Enhanced Neutralizing Activity

Journal of Biological Chemistry ◽

10.1074/jbc.m307742200 ◽

2003 ◽

Vol 278 (44) ◽

pp. 43496-43507 ◽

Cited By ~ 132

Author(s):

Dan Lu ◽

Juqun Shen ◽

Marie D. Vil ◽

Haifan Zhang ◽

Xenia Jimenez ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Growth Factor Receptor ◽

Human Antibody ◽

Vascular Endothelial ◽

Neutralizing Activity ◽

Endothelial Growth Factor

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Inhibition of Both the Autocrine and the Paracrine Growth of Human Leukemia with a Fully Human Antibody Directed Against Vascular Endothelial Growth Factor Receptor 2

Leukemia & Lymphoma ◽

10.1080/10428190410001712225 ◽

2004 ◽

Vol 45 (9) ◽

pp. 1887-1897 ◽

Cited By ~ 28

Author(s):

Haifan Zhang ◽

Yiwen Li ◽

Hongli Li ◽

Rajiv Bassi ◽

Xenia Jimenez ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Growth Factor Receptor ◽

Human Antibody ◽

Human Leukemia ◽

Vascular Endothelial ◽

Endothelial Growth Factor

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Phage-derived fully human antibody scFv fragment directed against human vascular endothelial growth factor receptor 2 blocked its interaction with VEGF

Biotechnology Progress ◽

10.1002/btpr.1559 ◽

2012 ◽

Vol 28 (4) ◽

pp. 981-989 ◽

Cited By ~ 12

Author(s):

Juan Zhang ◽

Haixin Li ◽

Xiuyun Wang ◽

Haidi Qi ◽

Xiaoniu Miao ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Growth Factor Receptor ◽

Human Antibody ◽

Vascular Endothelial ◽

Scfv Fragment ◽

Endothelial Growth Factor

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Fortgeschrittenes medulläres Schilddrüsenkarzinom: Vandetanib verbessert das progressionsfreie Überleben

Onkologische Welt ◽

10.1055/s-0038-1631032 ◽

2012 ◽

Vol 03 (02) ◽

pp. 93-92

Author(s):

Alexander Kretzschmar

Keyword(s):

Vascular Endothelial Growth Factor ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Phase Iii ◽

Vascular Endothelial ◽

Medulläres Schilddrüsenkarzinom ◽

Epidermal Growth ◽

Endothelial Growth Factor

Vandetanib ist ein oraler Hemmer des RET-Kinase-, VEGF (Vascular Endothelial Growth Factor Receptor)- und EGFR (Epidermal Growth Factor Receptor)-Signalwegs. In einer zulassungsrelevanten, randomisierten, doppelblinden, placebokontrollierten Phase- III-Studie verlängerte der Tyrosinkinasehemmer das progressionsfreie Überleben (PFS) signifikant länger als Placebo.

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Expression des „Epidermal Growth-Factor Receptor“ (EGFR) und des „Vascular Endothelial Growth Factor“ (VEGF) bei Lymphangioleiomyomatose (LAM)

Pneumologie ◽

10.1055/s-2006-934022 ◽

2006 ◽

Vol 60 (S 1) ◽

Author(s):

H Watz ◽

K Engels ◽

M Amthor ◽

D Kirsten ◽

H Magnussen

Keyword(s):

Vascular Endothelial Growth Factor ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Epidermal Growth ◽

Endothelial Growth Factor

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Faculty Opinions recommendation of Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1163678.625451 ◽

2009 ◽

Author(s):

David Bates

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Lymphatic Vessel ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Endogenous Inhibitor ◽

Vessel Growth ◽

Alternatively Spliced ◽

Endothelial Growth Factor

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Faculty Opinions recommendation of Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.11744956.12828054 ◽

2011 ◽

Author(s):

Asma Nusrat

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Receptor Antagonism ◽

Endothelial Growth Factor ◽

Α2β1 Integrin

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Faculty Opinions recommendation of Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.11744956.13740054 ◽

2011 ◽

Author(s):

Richard L Stevens

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Receptor Antagonism ◽

Endothelial Growth Factor ◽

Α2β1 Integrin

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Faculty Opinions recommendation of 111In-bevacizumab imaging of renal cell cancer and evaluation of neoadjuvant treatment with the vascular endothelial growth factor receptor inhibitor sorafenib.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717697854.793153053 ◽

2012 ◽

Author(s):

Hendrik van Poppel ◽

Yuri Tolkach

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Renal Cell Cancer ◽

Renal Cell ◽

Cell Cancer ◽

Neoadjuvant Treatment ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Endothelial Growth Factor ◽

Receptor Inhibitor

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Inhibition of the focal adhesion kinase and vascular endothelial growth factor receptor-3 interaction leads to decreased survival in human neuroblastoma cell lines

Molecular Carcinogenesis ◽

10.1002/mc.21969 ◽

2012 ◽

Vol 53 (3) ◽

pp. 230-242 ◽

Cited By ~ 1

Author(s):

Elizabeth A. Beierle ◽

Xiaojie Ma ◽

Jerry E. Stewart ◽

Michael Megison ◽

William G. Cance ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Focal Adhesion ◽

Neuroblastoma Cell ◽

Growth Factor Receptor ◽

Human Neuroblastoma Cell ◽

Vascular Endothelial ◽

Human Neuroblastoma ◽

Endothelial Growth Factor ◽

Neuroblastoma Cell Lines

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Characterization and development of a peptide substrate-based phosphate transfer assay for the human vascular endothelial growth factor receptor-2 tyrosine kinase

Analytical Biochemistry ◽

10.1016/j.ab.2006.10.038 ◽

2007 ◽

Vol 360 (2) ◽

pp. 196-206 ◽

Cited By ~ 4

Author(s):

Genshi Zhao ◽

Robert B. Peery ◽

Jonathan M. Yingling

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinase ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Peptide Substrate ◽

Endothelial Growth Factor

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