scholarly journals Cyclic GMP-dependent Protein Kinase Regulates CCAAT Enhancer-binding Protein β Functions through Inhibition of Glycogen Synthase Kinase-3

2005 ◽  
Vol 280 (38) ◽  
pp. 32683-32692 ◽  
Author(s):  
Xin Zhao ◽  
Shunhui Zhuang ◽  
Yongchang Chen ◽  
Gerry R. Boss ◽  
Renate B. Pilz
Keyword(s):  
Protein Kinase ◽  
Cyclic Gmp ◽  
Glycogen Synthase ◽  
Binding Protein ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Dependent Protein Kinase ◽  
Enhancer Binding Protein ◽  
Ccaat Enhancer Binding Protein ◽  
Dependent Protein

scholarly journals The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction

1999 ◽  
Vol 354 (1382) ◽  
pp. 485-495 ◽  
Author(s):  
Philip Cohen
Keyword(s):  
Protein Kinase ◽  
Glycogen Synthase ◽  
European Population ◽  
Glycogen Synthase Kinase 3 ◽  
Dependent Protein Kinase ◽  
Insulin Signal Transduction ◽  
Intracellular Proteins ◽  
Kinase Cascade ◽  
Dependent Protein ◽  
Protein Kinase Cascade

Diabetes affects 3% of the European population and 140 million people worldwide, and is largely a disease of insulin resistance in which the tissues fail to respond to this hormone. This emphasizes the importance of understanding how insulin signals to the cell's interior. We have recently dissected a protein kinase cascade that is triggered by the formation of the insulin ‘second messenger’ phosphatidylinositide (3,4,5) trisphosphate (PtdIns(3,4,5)P 3 ) and which appears to mediate many of the metabolic actions of this hormone. The first enzyme in the cascade is termed 3–phosphoinositide–dependent protein kinase–1 (PDK1), because it only activates protein kinase B (PKB), the next enzyme in the pathway, in the presence of PtdIns(3,4,5)P 3 . PKB then inactivates glycogen synthase kinase–3 (GSK3). PDK1, PKB and GSK3 regulate many physiological events by phosphorylating a variety of intracellular proteins. In addition, PKB plays an important role in mediating protection against apoptosis by survival factors, such as insulin–like growth factor–1.

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