scholarly journals Biochemical hepatic alterations and body lipid composition in the herbivorous grass carp (Ctenopharyngodon idella) fed high-fat diets

2006 ◽  
Vol 95 (5) ◽  
pp. 905-915 ◽  
Author(s):  
Zhen-Yu Du ◽  
Pierre Clouet ◽  
Wen-Hui Zheng ◽  
Pascal Degrace ◽  
Li-Xia Tian ◽  
...  
Keyword(s):  
Linolenic Acid ◽  
Grass Carp ◽  
Dietary Lipid ◽  
Ctenopharyngodon Idella ◽  
Fat Tissue ◽  
Lipid Levels ◽  
High Fat ◽  
Mesenteric Fat ◽  
High Fat Diets ◽  
Fat Diets

High-fat diets may have favourable effects on growth of some carnivorous fish because of the protein-sparing effect of lipids, but high-fat diets also exert some negative impacts on flesh quality. The goal of the study was therefore to determine the effects of fat-enriched diets in juvenile grass carp (Ctenopharyngodon idella) as a typical herbivorous fish on growth and possible lipid metabolism alterations. Three isonitrogenous diets containing 2, 6 or 10% of a mixture of lard, maize oil and fish oil (1:1:1, by weight) were applied to fish for 8 weeks in a recirculation system. Data show that feeding diets with increasing lipid levels resulted in lowered feed intake, decreased growth and feed efficiency, and increased mesenteric fat tissue weight. Concomitantly, alteration of lipoprotein synthesis and greater level of lipid peroxidation were apparent in blood. In liver, muscle and mesenteric fat tissue, the percentages of α-linolenic acid and DHA were significantly increased or tended to increase with higher dietary lipid levels. Biochemical activity measurements performed on liver showed that, with the increase in dietary lipid level, there was a decrease in both mitochondrial and peroxisomal fatty acid oxidation capacities, which might contribute, at least in part, to the specific accumulation of α-linolenic acid and DHA into cells more active in membrane building. On the whole, grass carp have difficulty in energetically utilising excess dietary fat, especially when enriched in n−3 PUFA that are susceptible to peroxidation.

scholarly journals Metabolic markers in Ossabaw pigs fed high fat diets enriched in regular or low α-linolenic acid soy oil

2013 ◽  
Vol 10 (1) ◽  
pp. 27 ◽  
Author(s):  
Ramesh B Potu ◽  
Hang Lu ◽  
Olayiwola Adeola ◽  
Kolapo M Ajuwon
Keyword(s):  
Linolenic Acid ◽  
Soy Oil ◽  
High Fat ◽  
Metabolic Markers ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Effects of Three-Month Administration of High-Saturated Fat Diet and High-Polyunsaturated Fat Diets with Different Linoleic Acid (LA, C18:2n–6) to α-Linolenic Acid (ALA, C18:3n–3) Ratio on the Mouse Liver Proteome

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1678
Author(s):  
Kamila P. Liput ◽  
Adam Lepczyński ◽  
Agata Nawrocka ◽  
Ewa Poławska ◽  
Magdalena Ogłuszka ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Linolenic Acid ◽  
Mouse Liver ◽  
Saturated Fat ◽  
Standard Diet ◽  
High Fat ◽  
Two Dimensional Gel Electrophoresis ◽  
Altered Expression ◽  
High Fat Diets ◽  
Fat Diets

The aim of the study was to evaluate the effect of different types of high-fat diets (HFDs) on the proteomic profile of mouse liver. The analysis included four dietary groups of mice fed a standard diet (STD group), a high-fat diet rich in SFAs (SFA group), and high-fat diets dominated by PUFAs with linoleic acid (LA, C18:2n–6) to α-linolenic acid (ALA, C18:3n–3) ratios of 14:1 (14:1 group) and 5:1 (5:1 group). After three months of diets, liver proteins were resolved by two-dimensional gel electrophoresis (2DE) using 17 cm non-linear 3–10 pH gradient strips. Protein spots with different expression were identified by MALDI-TOF/TOF. The expression of 13 liver proteins was changed in the SFA group compared to the STD group (↓: ALB, APOA1, IVD, MAT1A, OAT and PHB; ↑: ALDH1L1, UniProtKB—Q91V76, GALK1, GPD1, HMGCS2, KHK and TKFC). Eleven proteins with altered expression were recorded in the 14:1 group compared to the SFA group (↓: ARG1, FTL1, GPD1, HGD, HMGCS2 and MAT1A; ↑: APOA1, CA3, GLO1, HDHD3 and IVD). The expression of 11 proteins was altered in the 5:1 group compared to the SFA group (↓: ATP5F1B, FTL1, GALK1, HGD, HSPA9, HSPD1, PC and TKFC; ↑: ACAT2, CA3 and GSTP1). High-PUFA diets significantly affected the expression of proteins involved in, e.g., carbohydrate metabolism, and had varying effects on plasma total cholesterol and glucose levels. The outcomes of this study revealed crucial liver proteins affected by different high-fat diets.

Adaptations of lipid metabolism and food intake in response to low and high fat diets in juvenile grass carp (Ctenopharyngodon idellus)

Aquaculture ◽  
2016 ◽  
Vol 457 ◽  
pp. 43-49 ◽  
Author(s):  
Aixuan Li ◽  
Xiaochen Yuan ◽  
Xu-Fang Liang ◽  
Liwei Liu ◽  
Jie Li ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Food Intake ◽  
Grass Carp ◽  
Ctenopharyngodon Idellus ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Alpha-Linolenic Acid-Enriched Butter Promotes Fatty Acid Remodeling and Thermogenic Activation in the Brown Adipose Tissue

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 136 ◽  
Author(s):  
Mikyoung You ◽  
Rong Fan ◽  
Judy Kim ◽  
Seung-Ho Shin ◽  
Soonkyu Chung
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Linolenic Acid ◽  
High Fat Diet ◽  
Cold Treatment ◽  
High Fat ◽  
Alpha Linolenic Acid ◽  
Brown Adipose ◽  
High Fat Diets ◽  
Fat Diets

Supplementation with n-3 long-chain (LC) polyunsaturated fatty acids (PUFA) is known to promote thermogenesis via the activation of brown adipose tissue (BAT). Agricultural products that are biofortified with α-linolenic acid (ALA), the precursor of n-3 LC PUFA, have been launched to the market, but their impact on BAT function is unknown. This study aimed to evaluate the effects of ALA-biofortified butter on lipid metabolism and thermogenic functions in the BAT. C57BL/6 mice were fed a high-fat diet containing ALA-biofortified butter (n3Bu, 45% calorie from fat) for ten weeks in comparison with the isocaloric high-fat diets prepared from conventional butter or margarine. The intake of n3Bu significantly reduced the whitening of BAT and increased the thermogenesis in response to acute-cold treatment. Also, n3Bu supplementation is linked with the remodeling of BAT by promoting bioconversion into n-3 LC PUFA, FA elongation and desaturation, and mitochondrial biogenesis. Taken together, our results support that ALA-biofortified butter is a novel source of n-3 PUFA, which potentiates the BAT thermogenic function.

scholarly journals Diets Enriched in Fish-Oil or Seal-Oil have Distinct Effects on Lipid Levels and Peroxidation in BioF1B Hamsters

2011 ◽  
Vol 4 ◽  
pp. NMI.S6728 ◽  
Author(s):  
Pratibha Dubey ◽  
Anura P. Jayasooriya ◽  
Sukhinder K. CheemaΨ
Keyword(s):  
Fish Oil ◽  
Positional Distribution ◽  
Omega 3 ◽  
Lipid Levels ◽  
High Fat ◽  
Hepatic Lipids ◽  
High Fat Diets ◽  
Seal Oil ◽  
Fat Diets ◽  
And Oxidative Stress

Aim Fish-oil omega-3 polyunsaturated fatty acids (n-3 PUFAs) are mostly esterified to the sn-2 position of triglycerides, while in seal-oil triglycerides, these are mostly esterified to the sn-1 and −3 positions. We investigated whether fish-oil and seal-oil feeding has a different effect on the regulation of lipid metabolism and oxidative stress in BioF1B hamsters. Methods BioF1B hamsters were fed high fat diets rich in fish-oil or seal-oil for 4 weeks, and fasted for 14 hours prior to blood and tissue collection. Results Plasma and hepatic lipids and lipid peroxidation levels were significantly lower in seal-oil-fed hamsters as compared to those fed fish-oil. There was a selective hindrance of clearance of lipids in fish-oil-fed hamsters as reflected by higher levels of plasma apoB48. Conclusion Differences in the fatty acid composition and positional distribution of n-3 PUFAs in triglycerides of fish-oil and seal-oil are suggested to trigger metabolic differences.

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