Soluble CD14 in human breast milk and its role in innate immune responses

2001 ◽  
Vol 59 (5) ◽  
pp. 330-334 ◽  
Author(s):  
Karine Vidal ◽  
Mario O. Labéta ◽  
Eduardo J. Schiffrin ◽  
Anne Donnet-Hughes
Keyword(s):  
Breast Milk ◽  
Immune Responses ◽  
Innate Immune ◽  
Human Breast Milk ◽  
Innate Immune Responses ◽  
Human Breast ◽  
Soluble Cd14

scholarly journals Human Breast Milk and the Gastrointestinal Innate Immune System

2014 ◽  
Vol 41 (2) ◽  
pp. 423-435 ◽  
Author(s):  
Brett M. Jakaitis ◽  
Patricia W. Denning
Keyword(s):  
Immune System ◽  
Breast Milk ◽  
Innate Immune System ◽  
Innate Immune ◽  
Human Breast Milk ◽  
Human Breast

Soluble CD14 concentration in human breast milk and its potential role in child atopic dermatitis: Results of the Ulm Birth Cohort Studies

2018 ◽  
Vol 49 (2) ◽  
pp. 199-206 ◽  
Author(s):  
Chad A. Logan ◽  
Johannes M. Weiss ◽  
Wolfgang Koenig ◽  
Bernd Stahl ◽  
Prudence R. Carr ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Breast Milk ◽  
Cohort Studies ◽  
Birth Cohort ◽  
Potential Role ◽  
Human Breast Milk ◽  
Human Breast ◽  
Soluble Cd14

scholarly journals Effect of human breast milk on innate immune response: Up-regulation of bacterial pattern recognition receptors and innate cytokines in THP-1 monocytic cells

2021 ◽  
Vol 19 ◽  
pp. 205873922110261
Author(s):  
Won-Ho Hahn ◽  
Soon Young Shin ◽  
Jun Hwan Song ◽  
Nam Mi Kang
Keyword(s):  
Immune Response ◽  
Pattern Recognition ◽  
Breast Milk ◽  
Phagocytic Activity ◽  
Pattern Recognition Receptors ◽  
Innate Immune ◽  
Human Breast Milk ◽  
Human Breast ◽  
Monocytic Cells ◽  
Raw264.7 Macrophages

Human breast milk (HBM) contains many bioactive components that protect infants from various microorganisms. Pattern recognition receptors on phagocytic cells recognize microbial pathogens and promote the innate immune system. This study aimed to evaluate the effect of HBM on the expression of pattern recognition receptors and innate cytokines in the monocytic cell line THP-1 and the phagocytic activity of RAW264.7 macrophages. Expression levels of specific mRNAs in THP-1 cells were quantitated using reverse transcription-polymerase chain reaction. Phagocytic activity was measured by fluorescence microscopy to detect the uptake of fluorescent dye-labeled carboxylate-modified polystyrene latex beads in RAW264.7 macrophages. HBM stimulated the phagocytic activity of RAW264.7 macrophages. HBM increased mRNA expression of pattern recognition receptors, including the cluster of differentiation 14 and toll-like receptor 2 and 4, and various innate cytokines, including tumor necrosis factor α, interleukin-1β, C-X-C motif chemokine 8, and C-C motif chemokine ligand 2, in THP-1 monocytic cells. Furthermore, milk oligosaccharides in HBM, such as lacto- N-fucopentaose I, enhanced the expression of pattern recognition receptors and various innate cytokines. HBM is able to modulate the innate immune response by upregulating the expression of pattern recognition receptors and various innate cytokines in monocytes/macrophages.

Oral Immune Activation by Disgust and Disease-Related Pictures

2015 ◽  
Vol 29 (3) ◽  
pp. 119-129 ◽  
Author(s):  
Richard J. Stevenson ◽  
Deborah Hodgson ◽  
Megan J. Oaten ◽  
Luba Sominsky ◽  
Mehmet Mahmut ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Innate Immune Response ◽  
Negative Control ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Immune Markers ◽  
Before And After ◽  
Secondary Analyses ◽  
Image Set

Abstract. Both disgust and disease-related images appear able to induce an innate immune response but it is unclear whether these effects are independent or rely upon a common shared factor (e.g., disgust or disease-related cognitions). In this study we directly compared these two inductions using specifically generated sets of images. One set was disease-related but evoked little disgust, while the other set was disgust evoking but with less disease-relatedness. These two image sets were then compared to a third set, a negative control condition. Using a wholly within-subject design, participants viewed one image set per week, and provided saliva samples, before and after each viewing occasion, which were later analyzed for innate immune markers. We found that both the disease related and disgust images, relative to the negative control images, were not able to generate an innate immune response. However, secondary analyses revealed innate immune responses in participants with greater propensity to feel disgust following exposure to disease-related and disgusting images. These findings suggest that disgust images relatively free of disease-related themes, and disease-related images relatively free of disgust may be suboptimal cues for generating an innate immune response. Not only may this explain why disgust propensity mediates these effects, it may also imply a common pathway.

Innate immune responses and type 1 diabetes: A role for a long non-coding RNA?

2014 ◽  
Vol 9 (S 01) ◽  
Author(s):  
MP Ashton ◽  
I Tan ◽  
L Mackin ◽  
C Elso ◽  
E Chu ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Non Coding Rna ◽  
Long Non Coding Rna
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