The Effect of Ramatroban (BAY u 3405), a Thromboxane A 2 Receptor Antagonist, on Nasal Cavity Volume and Minimum Cross-Sectional Area and Nasal Mucosal Hemodynamics after Nasal Mucosal Allergen Challenge in Patients with Perennial Allergic Rhinitis

1998 ◽  
Vol 118 (537) ◽  
pp. 32-37 ◽  
Author(s):  
Nobuhisa Terada, Takayuki Yamakoshi, Masaya
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Cavity ◽  
Receptor Antagonist ◽  
Allergen Challenge ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Cavity Volume ◽  
Perennial Allergic Rhinitis ◽  
Cross Sectional

scholarly journals A comparison of minimal cross sectional areas, nasal volumes and peak nasal inspiratory flow between patients with obstructive sleep apnea and healthy controls

2016 ◽  
Vol 54 (4) ◽  
pp. 342-347
Author(s):  
M.H.S. Moxness ◽  
V. Bugten ◽  
W.M. Thorstensen ◽  
S. Nordgard ◽  
G. Bruskeland
Keyword(s):  
Nasal Cavity ◽  
Inspiratory Flow ◽  
Cross Sectional Area ◽  
Healthy Controls ◽  
Sectional Area ◽  
Cavity Volume ◽  
Cross Sectional ◽  
The Mean ◽  
And Function ◽  
Peak Nasal Inspiratory Flow

Background: The differences in nasal geometry and function between OSA patients and healthy individuals are not known. Our aim was to evaluate the differences in nasal geometry and function using acoustic rhinometry (AR) and peak nasal inspiratory flow (PNIF) between an OSA population and healthy controls. Methodology: The study was designed as a prospective case-control study. Ninety-three OSA patients and 92 controls were enrolled from 2010 to 2015. The minimal cross-sectional area (MCA) and the nasal cavity volume (NCV) in two parts of the nose (MCA0-3/NCV0-3 and MCA3-5.2/NCV3-5.2) and PNIF were measured at baseline and after decongestion. Results: The mean MCA0-3 in the OSA group was 0.49 cm2; compared to 0.55 cm2 in controls. The mean NCV0-3 correspondingly was 2.51 cm3 compared to 2.73 cm3 in controls. PNIF measured 105 litres/minute in the OSA group and 117 litres/minute in the controls. Conclusions: OSA patients have a lower minimum cross-sectional area, nasal cavity volume and peak inspiratory flow compared to controls. Our study supports the view that changes in the nasal cavity may contribute to development of OSA.

Changes in the parameters of nasal breathing and parameters of the upper respiratory tract during orthognathic operations in patients with II and III skeletal class of jaw anomalies

2020 ◽  
pp. 22-27
Author(s):  
S.Sh. Gammadaeva ◽  
M.I. Misirkhanova ◽  
A.Yu. Drobyshev
Keyword(s):  
Respiratory Tract ◽  
Nasal Cavity ◽  
Nasal Septum ◽  
Cross Sectional Area ◽  
Upper Respiratory Tract ◽  
Sectional Area ◽  
Nasal Breathing ◽  
Cross Sectional ◽  
Skeletal Class ◽  
Upper Respiratory

The study analyzed the functional parameters of nasal breathing, linear parameters of the nasal aperture, nasal cavity and nasopharynx, volumetric parameters of the upper airways in patients with II and III skeletal class of jaw anomalies before and after orthognathic surgery. The respiratory function of the nose was assessed using a rhinomanometric complex. According to rhinoresistometry data, nasal resistance and hydraulic diameter were assessed. According to the data of acoustic rhinometry, the minimum cross-sectional area along the internal valve, the minimum cross-sectional area on the head of the inferior turbinate and nasal septum and related parameters were estimated. According to the CBCT data, the state of the nasal septum, the inferior turbinates, the nasal aperture, the state of the nasal cavity, and the linear values of the upper respiratory tract (nasopharynx) were analyzed. The patients were divided into 4 groups according to the classification of the patency of the nasal passages by

Evaluation of Nasal Passage Patency after Antigen and Histamine Challenge in Guinea Pigs by Acoustic Rhinometry

1997 ◽  
Vol 11 (1) ◽  
pp. 85-90 ◽  
Author(s):  
Setsuo Nakamoto ◽  
Yasuo Sakakura ◽  
Ole F. Pedersen ◽  
Kotaro Ukai
Keyword(s):  
Nasal Cavity ◽  
Guinea Pigs ◽  
Airway Resistance ◽  
Cross Sectional Area ◽  
Nasal Passage ◽  
Nasal Airway ◽  
Sectional Area ◽  
Cross Sectional ◽  
Percent Change ◽  
Nasal Airway Resistance

We investigated the effects of antigen and histamine on the nasal passage patency in guinea pigs with or without nasal allergy. The change of nasal patency was measured by acoustic rhinometry and nasal airway resistance. Acoustic reflections have been used in adult humans to determine nasal cavity dimensions in terms of cross-sectional areas as a function of the distance from the nostril. In order to measure nasal cavity dimensions in guinea pigs, we modified equipment for use in humans by decreasing sound tube dimensions, increasing sampling frequency, and applying a special nosepiece. The percent change of volume, minimum cross-sectional area, and nasal airway resistance showed the largest changes at 10 minutes after antigen challenge in sensitized guinea pigs. There was a significant correlation between the individual percent change of nasal airway resistance and volume or minimum cross-sectional area. Histamine, 102 to 105 μg/mL, caused a dose-dependent reduction in percent change of volume in the challenged side of nonsensitized guinea pigs, but not in the opposite side. These results indicate that the noninvasive acoustic reflections technique is useful in small experimental animals, especially to assess the effect of nasal cavity dimensions after the challenge of antigen or nonspecific stimuli.

Effects of the Breathe Right Nasal Strips on Nasal Ventilation

1997 ◽  
Vol 11 (5) ◽  
pp. 399-402 ◽  
Author(s):  
Jan Gosepath ◽  
Wolf J. Mann ◽  
Ronald G. Amedee
Keyword(s):  
Nasal Cavity ◽  
Physical Performance ◽  
Cross Sectional Area ◽  
Acoustic Rhinometry ◽  
Sectional Area ◽  
Nasal Breathing ◽  
Cross Sectional ◽  
Subjective Impression ◽  
Breathe Right Nasal Strips ◽  
And Training

The Breathe Right nasal strips are more and more commonly used, mainly by athletes, who hope to enhance their physical performance in competition and training. The effect of the device in such situations is uncertain and perhaps somewhat controversial. To investigate the effects of the nasal strips on nasal ventilation, 20 Caucasian individuals were objectively assessed using anterior rhinomanometry and acoustic rhinometry. The results showed a significant increase in all subjects of transnasal airflow and in the average cross-sectional area of the nasal cavity that quantifies objectively the subjective impression of improved nasal breathing. In such patients where an improvement in nasal ventilation is desired, the use of the Breathe Right nasal strips seems to offer a beneficial treatment.

Attenuation of cerebral vasospasm by systemic administration of an endothelin-A receptor antagonist, TBC 11251, in a rabbit model of subarachnoid hemorrhage

1997 ◽  
Vol 3 (4) ◽  
pp. E8 ◽  
Author(s):  
John E. Wanebo ◽  
Hunter G. Louis ◽  
Adam S. Arthur ◽  
Jie Zhou ◽  
Neal F. Kassell ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Receptor Antagonist ◽  
Cerebral Vasospasm ◽  
Rabbit Model ◽  
Systemic Administration ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Cross Sectional ◽  
Basilar Arteries ◽  
The Mean

Cerebral vasospasm is a major complication of subarachnoid hemorrhage (SAH) after the rupture of an intracranial aneurysm. Although the cause of cerebral vasospasm has not been fully established, several lines of evidence suggest that the vasoconstrictor peptide endothelin (ET) may play a crucial role. In the present study the potential of TBC 11251 (TBC), a newly developed ETA receptor antagonist, to prevent and/or reverse cerebral vasospasm was examined in a well-established rabbit model of SAH. Sixty-five New Zealand White rabbits were assigned to one of six groups. Experimental SAH was induced in rabbits comprising five of the groups by injecting autologous arterial blood into the cisterna magna. The treatment groups were as follows: 1) control (no SAH); 2) SAH only; 3) SAH + placebo at 24 and 36 hours (24/36); 4) SAH + TBC (24/36); 5) SAH + placebo twice daily (BID); and 6) SAH + TBC BID. All drug-treated animals received an intravenous dosage of 5 mg/kg TBC. After 48 hours, the animals were killed by intracardiac perfusion with fixative. The brainstems were removed and the basilar arteries (BAs) were prepared for histological examination. The cross-sectional area of each BA was measured using computer-assisted videomicroscopy by an investigator blind to the group from which it came. A one-way analysis of variance and paired group mean comparisons with the post-hoc Fisher least significant difference test were used for analysis of BA diameters and physiological parameters. The model provided reliable vasospasm, with the mean BA cross-sectional area constricting from 0.388 mm2 in the control group to 0.106 mm2 (27.4% of control) in the SAH only group. Treatment with TBC (24/36) after SAH (reversal protocol) produced a mean BA area of 0.175 mm2 (44.2% of control) which, although larger than the placebo group value of 0.135 mm2 (39.9% of control), was not statistically significant. However, treatment with TBC BID (prevention protocol) produced a mean BA area of 0.303 mm2 (78.1% of control) compared with the placebo BID value of 0.134 mm2 (34.6% of control); this effect was statistically significant (p < 0.01). There were no side effects noted and no differences in the mean arterial pressures between drug and placebo groups. These findings demonstrate that systemic administration of the ETA receptor antagonist TBC significantly attenuates cerebral vasospasm after SAH when given as a preventative therapy, and they provide additional support for the role of ET in the establishment of vasospasm.

scholarly journals Assessment of changes in the nasal airway after nonsurgical miniscrew-assisted rapid maxillary expansion in young adults

2018 ◽  
Vol 88 (4) ◽  
pp. 435-441 ◽  
Author(s):  
Soo-Yeon Kim ◽  
Young-Chel Park ◽  
Kee-Joon Lee ◽  
Andreas Lintermann ◽  
Sang-Sun Han ◽  
...  
Keyword(s):  
Young Adults ◽  
Nasal Cavity ◽  
Rapid Maxillary Expansion ◽  
Cross Sectional Area ◽  
Nasal Airway ◽  
Sectional Area ◽  
Maxillary Expansion ◽  
Cross Sectional ◽  
T1 And T2 ◽  
Observation Period

ABSTRACT Objectives: To evaluate changes in the volume and cross-sectional area of the nasal airway before and 1 year after nonsurgical miniscrew-assisted rapid maxillary expansion (MARME) in young adults. Materials and Methods: Fourteen patients (mean age, 22.7 years; 10 women, four men) with a transverse discrepancy who underwent cone beam computed tomography before (T0), immediately after (T1), and 1 year after (T2) expansion were retrospectively included in this study. The volume of the nasal cavity and nasopharynx and the cross-sectional area of the anterior, middle, and posterior segments of the nasal airway were measured and compared among the three timepoints using paired t-tests. Results: The volume of the nasal cavity showed a significant increase at T1 and T2 (P &lt; .05), while that of the nasopharynx increased only at T2 (P &lt; .05). The anterior and middle cross-sectional areas significantly increased at T1 and T2 (P &lt; .05), while the posterior cross-sectional area showed no significant change throughout the observation period (P &gt; .05). Conclusions: The results demonstrate that the volume and cross-sectional area of the nasal cavity increased after MARME and were maintained at 1 year after expansion. Therefore, MARME may be helpful in expanding the nasal airway.

Relationship between nasal cavity volume changes and nasalance

2008 ◽  
Vol 123 (4) ◽  
pp. 407-411 ◽  
Author(s):  
H Birkent ◽  
U Erol ◽  
M Ciyiltepe ◽  
T L Eadie ◽  
A Durmaz ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Sectional Area ◽  
Cavity Volume ◽  
Volume Changes ◽  
Cross Sectional ◽  
Acoustic Characteristics ◽  
Nasal Decongestant ◽  
The Relationship ◽  
The Voice ◽  
Adult Volunteers

AbstractObjectives:The patency and volume of the nasal cavity affect the acoustic characteristics of the voice. The aim of this study was to investigate the effect of a nasal decongestant on nasal volumes and nasalance scores, and to determine the relationship between these measures.Methods:Acoustic rhinometry and nasometry were performed in a group of 21 adult volunteers both prior to and following application of a nasal decongestant. The relationship between changes in nasalance scores and acoustic rhinometric parameters was investigated.Results:After the application of nasal decongestant, statistically significant increases were observed in nasalance scores and in all of the acoustic rhinometric parameters assessed (i.e. minimal cross-sectional area, three cross-sectional areas, three volumes and total volume). However, no significant correlation was found between the changes in nasalance scores and acoustic rhinometric parameters.Conclusions:Nasal decongestion causes an increase in nasalance scores and nasal cavity volumes. However, the findings of this study indicate that changes in nasalance scores may result from factors other than nasal cavity volume changes.

Sign in / Sign up

Export Citation Format

Share Document