The Relationship of Upper Respiratory Infections to Congestive Heart-failure in Patients With Heart Disease

1956 ◽  
Vol 19 (5) ◽  
pp. 451-458
Author(s):  
Samuel Waldman ◽  
Louis Pelner
Animals ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1828
Author(s):  
Charlotte C. Burns ◽  
Laurel E. Redding ◽  
Brittany Watson

Reducing stress is important to maintaining the health of shelter cats and decreasing the risk of upper respiratory disease (URD). The aim of this study was to determine if the frequency and/or duration of daily routine handling of shelter cats affects the likelihood of URD development. At a closed admission shelter, each cat free of URD on intake was given a cage card for recording handling data. These data included: date and times when the cat was handled, duration of handling, if and when the cat developed signs of URD, and the handler identity. Cox regression was used to determine the relationship between these factors and URD development. We found cats that did not develop URD were handled significantly more than cats that did (1.1 times per day vs. 0.7 times per day, p < 0.001). Increased frequency of handling had a borderline significant effect on the hazard of developing URD (HR 0.37; CI: 0.13–1.1; p = 0.066). No other parameters were significantly associated with the development of URD; however, small sample size may be responsible for this finding. A larger study is needed to elucidate the relationship between handling and URD development.


PEDIATRICS ◽  
1960 ◽  
Vol 26 (4) ◽  
pp. 674-678
Author(s):  
James A. Wolff ◽  
Anneliese L. Sitarz ◽  
Frederick H. Von Hofe

The effects of splenectomy in 18 children with thalassemia (Mediterranean anemia) are evaluated. The subjects varied in age at the time of splenectomy from 1½ to 18½ years and have been followed for 5 months to 28 years since operation. One death occurred at the time of splenectomy, during induction of anesthesia. All patients, even those who later died, benefited initially from splenectomy. They required fewer transfusions and maintained higher hemoglobin levels subsequently for varying periods of time. Of the 18 patients, 7 have died; all but 2 of these developed chronic congestive heart failure late in the course of the disease. Pericarditis was suspected in life and proven at necropsy in three subjects. No definite proof of the relationship of splenectomy to the incidence of penicarditis has been shown. In this small series of patients no significantly increased incidence of severe infection was observed postoperatively.


2015 ◽  
Vol 45 (2) ◽  
pp. 83-89 ◽  
Author(s):  
Maria Kneider ◽  
Vera Lisovskaja ◽  
Jan Lycke ◽  
Clas Malmeström ◽  
Johannes K. Jakobsen ◽  
...  

Background: Although clinical reports have suggested a relationship between systemic infections and multiple sclerosis (MS) relapses, MRI evidence supporting an association is conflicting. Here we evaluated the temporal relationship between upper respiratory infections (URIs) and MRI activity in relapsing-remitting (RR) MS. Methods: We combined individual data on URI with data on active lesions in pre-scheduled MRI examinations performed every 4 weeks for 28 weeks in 69 patients. A 4-week at-risk (AR) period started, by definition, 1 week before the onset of a URI. We recorded the relationship between the number of active lesions in each MRI with (1) the number of days of AR time in the immediately preceding 4-week period and (2) the number of days passed since the onset of a preceding URI. Results: Average MRI lesions/day showed no difference between AR (0.0764) and not-AR (0.0774) periods. The number of lesions in 483 pre-scheduled MRI examinations did not correlate with the AR proportion in the prior 4-week period (rho = -0.03), and time from URI onset did not correlate with lesion number on the next MRI examination (rho = 0.003). Conclusion: The occurrence of a URI did not increase the risk of MRI activity evaluated in an adjacent 4-week window in RRMS.


Author(s):  
Jade H. Singleton ◽  
Erin L. Abner ◽  
Peter D. Akpunonu ◽  
Anna M. Kucharska‐Newton

BACKGROUND In this scoping review, we identified and reviewed 23 original articles from the PubMed database that investigated the relationship between nonacute opioid use (NOU) and cardiovascular outcomes. METHODS AND RESULTS We defined NOU to include both long‐term opioid therapy and opioid use disorder. We summarized the association between NOU and 5 classes of cardiovascular disease, including infective endocarditis, coronary heart disease (including myocardial infarction), congestive heart failure, cardiac arrythmia (including cardiac arrest), and stroke. The most commonly studied outcomes were coronary heart disease and infective endocarditis. There was generally consistent evidence of a positive association between community prevalence of injection drug use (with opioids being the most commonly injected type of drug) and community prevalence of infective endocarditis, and between (primarily medically indicated) NOU and myocardial infarction. There was less consensus about the relationship between NOU and congestive heart failure, cardiac arrhythmia, and stroke. CONCLUSIONS There is a dearth of high‐quality evidence on the relationship between NOU and cardiovascular disease. Innovative approaches to the assessment of opioid exposure over extended periods of time will be required to address this need.


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