Upregulation of OATP1A2 in human oesophageal squamous cell carcinoma cells via the HDAC6-GCN5/PCAF-H3K9Ac axis

Xenobiotica ◽  
2021 ◽  
pp. 1-10
Author(s):  
Xiaoli Zheng ◽  
Jian V. Zhang ◽  
Yanfeng Bai ◽  
Jiaqi Wang ◽  
Mingfeng Jiang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Oesophageal Squamous Cell Carcinoma

Olaparib Potentiates Anticancer Drug Cytotoxicity via 53BP1 in Oesophageal Squamous Cell Carcinoma Cells

2020 ◽  
Vol 40 (2) ◽  
pp. 813-823
Author(s):  
KEISUKE MIYAMOTO ◽  
TETSUYA MINEGAKI ◽  
SAYAKA HIRANO ◽  
ITSUKA HAYASHI ◽  
MASAYUKI TSUJIMOTO ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Anticancer Drug ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Oesophageal Squamous Cell Carcinoma

scholarly journals Metformin induces an intracellular reductive state that protects oesophageal squamous cell carcinoma cells against cisplatin but not copper-bis(thiosemicarbazones)

BMC Cancer ◽  
2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Leonard Howard Damelin ◽  
Rupal Jivan ◽  
Robin Bruce Veale ◽  
Amanda Louise Rousseau ◽  
Demetra Mavri-Damelin
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Oesophageal Squamous Cell Carcinoma

scholarly journals Methylseleninic acid activates Keap1/Nrf2 pathway via up-regulating miR-200a in human oesophageal squamous cell carcinoma cells

2015 ◽  
Vol 35 (5) ◽  
Author(s):  
Mei Liu ◽  
Chenfei Hu ◽  
Qing Xu ◽  
Lechuang Chen ◽  
Kai Ma ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Second Generation ◽  
Carcinoma Cells ◽  
Oesophageal Squamous Cell Carcinoma ◽  
Nrf2 Pathway ◽  
Selenium Compound ◽  
Methylseleninic Acid

Methylseleninic acid (MSA), as a potent second-generation selenium compound, could activate KLF4/miR-200a/Keap1/Nrf2 pathway in oesophageal squamous cell carcinoma cells.

scholarly journals CDCA2 promotes tumorigenesis and induces radioresistance in oesophageal squamous cell carcinoma cells

2021 ◽  
Vol 24 (1) ◽  
Author(s):  
Bing Xu ◽  
Hui Chen ◽  
Zhipeng Xu ◽  
Xijuan Yao ◽  
Xinchen Sun ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Oesophageal Squamous Cell Carcinoma

Isoliquiritigenin Inhibits Proliferation and Induces Apoptosis in Tongue Squamous Cell Carcinoma by Modulating miR-21/FOXG1 Pathway

2019 ◽  
Vol 17 (4) ◽  
pp. 463-469
Author(s):  
Hou Deqiang ◽  
Gao Yufeng ◽  
Bai Ning ◽  
Dong Yu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Tongue Squamous Cell Carcinoma ◽  
Luciferase Assay ◽  
Forkhead Box ◽  
Proliferation And Apoptosis ◽  
Mrna And Protein Expression ◽  
Induced Apoptosis

Isoliquiritigenin is a flavonoid commonly found in liquorice and has been identified as a potent anti-tumor agent. The aim of this study was to investigate whether isoliquiritigenin regulates the proliferation and apoptosis of tongue squamous cell carcinoma cells by regulating forkhead box G1 expression via miR-21. MTT assay and flow cytometry were used to analyze cell proliferation and apoptosis, respectively. Quantitative real time polymerase chain reaction and western blotting were used to detect mRNA and protein expression levels, respectively. The relationship between miR-21 and forkhead box G1 was detected by dual luciferase assay. Isoliquiritigenin inhibited proliferation and induced apoptosis of tongue squamous cell carcinoma cells, and decreased miR-21 levels and promoted forkhead box G1 expression. Forkhead box G1 was then identified as a target of miR-21 and ISL could promote forkhead box G1 expression by inhibiting miR-21. Further analysis suggested that upregulation of miR-21 improved proliferation and suppressed apoptosis of tongue squamous cell carcinoma cells by inhibiting forkhead box G1 expression. Finally, our results revealed that isoliquiritigenin inhibited proliferation and induced apoptosis of tongue squamous cell carcinoma cells by regulating miR-21. Isoliquiritigenin might act as a novel therapeutic treatment for tongue squamous cell carcinoma cells through up-regulation of forkhead box G1 expression via inhibiting miR-21expression.

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