scholarly journals Are Diet Quality Scores After Breast Cancer Diagnosis Associated with Improved Breast Cancer Survival?

2013 ◽  
Vol 65 (6) ◽  
pp. 820-826 ◽  
Author(s):  
Monika A. Izano ◽  
Teresa T. Fung ◽  
Stephanie S. Chiuve ◽  
Frank B. Hu ◽  
Michelle D. Holmes
Keyword(s):  
Breast Cancer ◽  
Cancer Diagnosis ◽  
Diet Quality ◽  
Cancer Survival ◽  
Breast Cancer Diagnosis ◽  
Breast Cancer Survival

25-Hydroxyvitamin D at time of breast cancer diagnosis and breast cancer survival

2019 ◽  
Vol 179 (3) ◽  
pp. 699-708 ◽  
Author(s):  
Charlotte Kanstrup ◽  
Dorthe Teilum ◽  
Lars Rejnmark ◽  
Janne Villemoes Bigaard ◽  
Pia Eiken ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Diagnosis ◽  
Cancer Survival ◽  
Breast Cancer Diagnosis ◽  
Breast Cancer Survival ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria Escala-Garcia ◽  
Sander Canisius ◽  
Renske Keeman ◽  
Jonathan Beesley ◽  
Hoda Anton-Culver ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Diagnosis ◽  
Primary Breast Cancer ◽  
Cancer Survival ◽  
Distant Metastases ◽  
Breast Cancer Diagnosis ◽  
Breast Cancer Survival ◽  
European Ancestry ◽  
Validation Dataset ◽  
Germline Variants

AbstractBreast cancer metastasis accounts for most of the deaths from breast cancer. Identification of germline variants associated with survival in aggressive types of breast cancer may inform understanding of breast cancer progression and assist treatment. In this analysis, we studied the associations between germline variants and breast cancer survival for patients with distant metastases at primary breast cancer diagnosis. We used data from the Breast Cancer Association Consortium (BCAC) including 1062 women of European ancestry with metastatic breast cancer, 606 of whom died of breast cancer. We identified two germline variants on chromosome 1, rs138569520 and rs146023652, significantly associated with breast cancer-specific survival (P = 3.19 × 10−8 and 4.42 × 10−8). In silico analysis suggested a potential regulatory effect of the variants on the nearby target genes SDE2 and H3F3A. However, the variants showed no evidence of association in a smaller replication dataset. The validation dataset was obtained from the SNPs to Risk of Metastasis (StoRM) study and included 293 patients with metastatic primary breast cancer at diagnosis. Ultimately, larger replication studies are needed to confirm the identified associations.

Residential Greenness and Breast Cancer Survival after a Breast Cancer Diagnosis

2018 ◽  
Vol 2018 (1) ◽  
Author(s):  
Natalie DuPre ◽  
Peter James ◽  
Jaime E Hart ◽  
Trang VoPham ◽  
Cheng Peng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Diagnosis ◽  
Cancer Survival ◽  
Breast Cancer Diagnosis ◽  
Breast Cancer Survival

scholarly journals Alcohol Consumption Before and After Breast Cancer Diagnosis: Associations With Survival From Breast Cancer, Cardiovascular Disease, and Other Causes

2013 ◽  
Vol 31 (16) ◽  
pp. 1939-1946 ◽  
Author(s):  
Polly A. Newcomb ◽  
Ellen Kampman ◽  
Amy Trentham-Dietz ◽  
Kathleen M. Egan ◽  
Linda J. Titus ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Alcohol Consumption ◽  
Alcohol Intake ◽  
Cancer Survival ◽  
Breast Cancer Diagnosis ◽  
Breast Cancer Survival ◽  
Disease Specific Survival ◽  
Increased Risk ◽  
Disease Specific

Purpose Alcohol intake is associated with increased risk of breast cancer. In contrast, the relation between alcohol consumption and breast cancer survival is less clear. Patients and Methods We assessed pre- and postdiagnostic alcohol intake in a cohort of 22,890 women with incident invasive breast cancer who were residents of Wisconsin, Massachusetts, or New Hampshire and diagnosed from 198 to 200 at ages 20 to 79 years. All women reported on prediagnostic intake; a subsample of 4,881 reported on postdiagnostic intake. Results During a median follow-up of 11.3 years from diagnosis, 7,780 deaths occurred, including 3,484 resulting from breast cancer. Hazard ratios (HR) and 95% CIs were estimated. Based on a quadratic analysis, moderate alcohol consumption before diagnosis was modestly associated with disease-specific survival (compared with nondrinkers, HR = 0.93 [95% CI, 0.85 to 1.02], 0.85 [95% CI, 0.75 to 0.95], 0.88 [95% CI, 0.75 to 1.02], and 0.89 [95% CI, 0.77 to 1.04] for two or more, three to six, seven to nine, and ≥ 10 drinks/wk, respectively). Alcohol consumption after diagnosis was not associated with disease-specific survival (compared with nondrinkers, HR = 0.88 [95% CI, 0.61 to 1.27], 0.80 [95% CI, 0.49 to 1.32], 1.01 [95% CI, 0.55 to 1.87], and 0.83 [95% CI, 0.45 to 1.54] for two or more, three to six, seven to nine, and ≥ 10 drinks/wk, respectively). Results did not vary by beverage type. Women consuming moderate levels of alcohol, either before or after diagnosis, experienced better cardiovascular and overall survival than nondrinkers. Conclusion Overall alcohol consumption before diagnosis was not associated with disease-specific survival, but we found a suggestion favoring moderate consumption. There was no evidence for an association with postdiagnosis alcohol intake and breast cancer survival. This study, however, does provide support for a benefit of limited alcohol intake for cardiovascular and overall survival in women with breast cancer.

scholarly journals Diet Quality Indices and Postmenopausal Breast Cancer Survival

2011 ◽  
Vol 63 (3) ◽  
pp. 381-388 ◽  
Author(s):  
Esther Kim ◽  
Walter Willett ◽  
Teresa Fung ◽  
Bernard Rosner ◽  
Michelle Holmes
Keyword(s):  
Breast Cancer ◽  
Diet Quality ◽  
Cancer Survival ◽  
Postmenopausal Breast Cancer ◽  
Breast Cancer Survival ◽  
Quality Indices

scholarly journals Age at first childbirth and breast cancer survival: a prospective cohort study

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Johanna Aurin ◽  
Henrik Thorlacius ◽  
Salma Tunå Butt
Keyword(s):  
Breast Cancer ◽  
Cancer Survival ◽  
Reference Group ◽  
Age Groups ◽  
Breast Cancer Diagnosis ◽  
Breast Cancer Survival ◽  
Age At First Birth ◽  
Cancer Specific Survival ◽  
Established Risk Factor ◽  
Nulliparous Women

Abstract Objective Late age at first childbirth is a well-established risk factor for breast cancer. Previous studies have, however, shown conflicting results to whether late age at first childbirth also influences the prognosis of breast cancer survival. The aim of this study was to examine age at first birth in relation to survival after breast cancer diagnosis. Results We used information from the Malmö Diet and Cancer study. At baseline 17,035 women were included. All women were followed from the year they developed breast cancer until they either died or until the end of follow-up. All women were asked how many children they had given birth to and were then divided into different groups, ≤ 20, > 20 to  ≤ 25, > 25 to  ≤ 30 and > 30. Nulliparous women form a separate group. Survival analyses were then performed using Cox proportional hazard survival analysis. Women in all age groups had a lower risk of breast cancer specific death as compared to the reference group ≤ 20, however non-significantly. Nulliparous women had a higher risk of breast cancer specific death as compared to the same reference group, however these results were not statistically significant. We could not see any negative effect of late first childbirth on breast cancer specific survival.

scholarly journals Improvements in US Breast Cancer Survival and Proportion Explained by Tumor Size and Estrogen-Receptor Status

2015 ◽  
Vol 33 (26) ◽  
pp. 2870-2876 ◽  
Author(s):  
Ju-Hyun Park ◽  
William F. Anderson ◽  
Mitchell H. Gail
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Tumor Size ◽  
Cancer Survival ◽  
Estrogen Receptor Status ◽  
Breast Cancer Mortality ◽  
Breast Cancer Diagnosis ◽  
The United States ◽  
Breast Cancer Survival ◽  
Er Status

Purpose Breast cancer mortality began declining in many Western countries during the late 1980s. We estimated the proportion of improvements in stage- and age-specific breast cancer survival in the United States explained by tumor size or estrogen receptor (ER) status. Methods We estimated hazard ratios for breast cancer–specific death from time of invasive breast cancer diagnosis in the National Cancer Institute's Surveillance, Epidemiology, and End Results 9 Registries Database from 1973 to 2010, with and without stratification by tumor size and ER status. Results Hazards from breast cancer–specific death declined from 1973 to 2010, not only in the first 5 years after diagnosis, but also thereafter. Stratification by tumor size explained less than 17% of the improvements comparing 2005 to 2010 versus 1973 to 1979, except for women age ≥ 70 years with local (49%) or regional (38%) disease. Tumor size usually accounted for more of the improvement in the first 5 years after diagnosis than later. Additional adjustment for ER status (positive, negative, or unknown) from 1990 to 2010 did not explain much more of the improvement, except for women age ≥ 70 years within 5 years after diagnosis. Conclusion Most stage-specific survival improvement in women younger than age 70 years old is unexplained by tumor size and ER status, suggesting a key role for treatment. In the first 5 years after diagnosis, tumor size contributed importantly for women ≥ 70 years old with local and regional stage, and stratification by tumor size and ER status explained even more of the survival improvement among women age ≥ 70 years.

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