Prospective longitudinal decline in cognitive-communication skills following treatment for childhood brain tumor

Brain Injury ◽  
2021 ◽  
pp. 1-8
Author(s):  
Kimberley M. Docking ◽  
Stefani R. Knijnik
Keyword(s):  
Brain Tumor ◽  
Communication Skills ◽  
Childhood Brain Tumor ◽  
Prospective Longitudinal

scholarly journals High Prevalence of Weight Gain in Childhood Brain Tumor Survivors and Its Association With Hypothalamic-Pituitary Dysfunction

2021 ◽  
pp. JCO.20.01765
Author(s):  
Jiska van Schaik ◽  
Ichelle M. A. A. van Roessel ◽  
Netteke A. Y. N. Schouten-van Meeteren ◽  
Laura van Iersel ◽  
Sarah C. Clement ◽  
...  
Keyword(s):  
Risk Factors ◽  
Brain Tumor ◽  
Weight Gain ◽  
Standard Deviation Score ◽  
Cardiometabolic Health ◽  
Low Grade ◽  
Childhood Brain Tumor ◽  
Significant Weight Gain ◽  
Overweight Or Obesity

PURPOSE Childhood brain tumor survivors (CBTS) are at risk for developing obesity, which negatively influences cardiometabolic health. The prevalence of obesity in CBTS may have been overestimated in previous cohorts because of inclusion of children with craniopharyngioma. On the contrary, the degree of weight gain may have been underestimated because of exclusion of CBTS who experienced weight gain, but were neither overweight nor obese. Weight gain may be an indicator of underlying hypothalamic-pituitary (HP) dysfunction. We aimed to study prevalence of and risk factors for significant weight gain, overweight, or obesity, and its association with HP dysfunction in a national cohort of noncraniopharyngioma and nonpituitary CBTS. METHODS Prevalence of and risk factors for significant weight gain (body mass index [BMI] change ≥ +2.0 standard deviation score [SDS]), overweight, or obesity at follow-up, and its association with HP dysfunction were studied in a nationwide cohort of CBTS, diagnosed in a 10-year period (2002-2012), excluding all craniopharyngioma and pituitary tumors. RESULTS Of 661 CBTS, with a median age at follow-up of 7.3 years, 33.1% had significant weight gain, overweight, or obesity. Of the CBTS between 4 and 20 years of age, 28.7% were overweight or obese, compared with 13.2% of the general population between 4 and 20 years of age. BMI SDS at diagnosis, diagnosis of low-grade glioma, diabetes insipidus, and central precocious puberty were associated with weight gain, overweight, or obesity. The prevalence of HP dysfunction was higher in overweight and obese CTBS compared with normal-weight CBTS. CONCLUSION Overweight, obesity, and significant weight gain are prevalent in CBTS. An increase in BMI during follow-up may be a reflection of HP dysfunction, necessitating more intense endocrine surveillance.

scholarly journals Late effects after childhood brain tumor treatment: it’s not just about the radiation

2019 ◽  
Vol 21 (5) ◽  
pp. 565-567 ◽  
Author(s):  
Derek S Tsang ◽  
Kim Edelstein
Keyword(s):  
Brain Tumor ◽  
Late Effects ◽  
Childhood Brain Tumor ◽  
Tumor Treatment

scholarly journals Genes differentially expressed in medulloblastoma and fetal brain

1999 ◽  
Vol 1 (2) ◽  
pp. 83-91 ◽  
Author(s):  
E. M. C. MICHIELS ◽  
E. OUSSOREN ◽  
M. VAN GROENIGEN ◽  
E. PAUWS ◽  
P. M. M. BOSSUYT ◽  
...  
Keyword(s):  
Gene Expression ◽  
Brain Tumor ◽  
Northern Blot ◽  
Fetal Brain ◽  
Differentially Expressed ◽  
P Value ◽  
Test Statistics ◽  
Childhood Brain Tumor ◽  
Germinal Layer ◽  
Test Statistic

Michiels, E. M. C., E. Oussoren, M. van Groenigen, E. Pauws, P. M. M. Bossuyt, P. A. Voûte, and F. Baas. Genes differentially expressed in medulloblastoma and fetal brain. Physiol. Genomics 1: 83–91, 1999.—Serial analysis of gene expression (SAGE) was used to identify genes that might be involved in the development or growth of medulloblastoma, a childhood brain tumor. Sequence tags from medulloblastoma (10229) and fetal brain (10692) were determined. The distributions of sequence tags in each population were compared, and for each sequence tag, pairwise χ2 test statistics were calculated. Northern blot was used to confirm some of the results obtained by SAGE. For 16 tags, the χ2 test statistic was associated with a P value < 10−4. Among those transcripts with a higher expression in medulloblastoma were the genes for ZIC1 protein and the OTX2 gene, both of which are expressed in the cerebellar germinal layers. The high expression of these two genes strongly supports the hypothesis that medulloblastoma arises from the germinal layer of the cerebellum. This analysis shows that SAGE can be used as a rapid differential screening procedure.

scholarly journals Childhood Brain Tumor Occurrence in Relation to Residential Power Line Configurations, Electric Heating Sources, and Electric Appliance Use

1996 ◽  
Vol 143 (2) ◽  
pp. 120-128 ◽  
Author(s):  
J. G. Gurney ◽  
B. A. Mueller ◽  
S. Davis ◽  
S. M. Schwartz ◽  
R. G. Stevens ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Electric Heating ◽  
Power Line ◽  
Childhood Brain Tumor

scholarly journals Assessment of the Hypothalamo-Pituitary-Adrenal Axis in Patients Treated with Radiotherapy and Chemotherapy for Childhood Brain Tumor

2003 ◽  
Vol 88 (7) ◽  
pp. 3149-3154 ◽  
Author(s):  
M. Schmiegelow ◽  
U. Feldt-Rasmussen ◽  
A. K. Rasmussen ◽  
M. Lange ◽  
H. S. Poulsen ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Childhood Brain Tumor ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

Childhood brain tumor update

1983 ◽  
Vol 14 (10) ◽  
pp. 834-845 ◽  
Author(s):  
Floyd H. Gilles ◽  
Alan Leviton ◽  
E. Tessa Hedley-Whyte ◽  
Michael Jasnow
Keyword(s):  
Brain Tumor ◽  
Childhood Brain Tumor

scholarly journals Neuropsychological Consequences for Survivors of Childhood Brain Tumor in Malaysia

2018 ◽  
Vol 9 ◽  
Author(s):  
Hamidah Alias ◽  
Sie Chong D. Lau ◽  
Ilse Schuitema ◽  
Leo M. J. de Sonneville
Keyword(s):  
Brain Tumor ◽  
Childhood Brain Tumor
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