A new formulation for transient response optimization of structures based on constraint aggregation functions

2021 ◽  
pp. 1-17
Author(s):  
I. Couceiro ◽  
J. París ◽  
L. Ramírez ◽  
F. Navarrina
Keyword(s):  
Transient Response ◽  
Constraint Aggregation ◽  
Aggregation Functions ◽  
Response Optimization ◽  
New Formulation

scholarly journals Isotretinoin Oil-Based Capsule Formulation Optimization

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Pi-Ju Tsai ◽  
Chi-Te Huang ◽  
Chen-Chou Lee ◽  
Chi-Lin Li ◽  
Yaw-Bin Huang ◽  
...  
Keyword(s):  
Coconut Oil ◽  
Multiple Response ◽  
Potential Influence ◽  
Capsule Formulation ◽  
Constrained Mixture ◽  
Systemic Model ◽  
Response Optimization ◽  
Formulation Factors ◽  
Main Factors ◽  
New Formulation

The purpose of this study was to develop and optimize an isotretinoin oil-based capsule with specific dissolution pattern. A three-factor-constrained mixture design was used to prepare the systemic model formulations. The independent factors were the components of oil-based capsule including beeswax (X1), hydrogenated coconut oil (X2), and soybean oil (X3). The drug release percentages at 10, 30, 60, and 90 min were selected as responses. The effect of formulation factors including that on responses was inspected by using response surface methodology (RSM). Multiple-response optimization was performed to search for the appropriate formulation with specific release pattern. It was found that the interaction effect of these formulation factors (X1X2,X1X3, andX2X3) showed more potential influence than that of the main factors (X1,X2, andX3). An optimal predicted formulation withY10 min,Y30 min,Y60 min, andY90 minrelease values of 12.3%, 36.7%, 73.6%, and 92.7% atX1,X2, andX3of 5.75, 15.37, and 78.88, respectively, was developed. The new formulation was prepared and performed by the dissolution test. The similarity factorf2was 54.8, indicating that the dissolution pattern of the new optimized formulation showed equivalence to the predicted profile.

Aggregation Functions

2009 ◽  
Author(s):  
Michel Grabisch ◽  
Jean-Luc Marichal ◽  
Radko Mesiar ◽  
Endre Pap
Keyword(s):  
Aggregation Functions
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