scholarly journals Effect of hypobaric hypoxia and diet on blood parameters and pulmonary hypertension‐induced right ventricular hypertrophy in turkey poults and ducklings

1993 ◽  
Vol 22 (4) ◽  
pp. 683-692 ◽  
Author(s):  
R. J. Julian ◽  
S. M. Mirsalimi ◽  
E. J. Squires
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Hypobaric Hypoxia ◽  
Ventricular Hypertrophy ◽  
Blood Parameters ◽  
Right Ventricular Hypertrophy ◽  
Turkey Poults

Alpha-skeletal actin messenger RNA increases in acute right ventricular hypertrophy

1990 ◽  
Vol 258 (4) ◽  
pp. L173-L178 ◽  
Author(s):  
P. R. Bakerman ◽  
K. R. Stenmark ◽  
J. H. Fisher
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Hypobaric Hypoxia ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy ◽  
Hypoxic Exposure ◽  
Mrna Levels ◽  
Severe Pulmonary Hypertension ◽  
Cardiac Actin ◽  
Actin Mrna

Newborn calves exposed to hypobaric hypoxia develop severe pulmonary hypertension. Right ventricular hypertrophy and failure occur as a consequence of the increased pressure load. Alterations in right ventricular myocyte performance or differentiation could be reflected by the changes in the expression of contractile protein genes. We studied expression of contractile actin isotypes by measuring mRNA levels in total cellular RNA purified from right (RV) and left ventricles (LV) of calves with severe pulmonary hypertension after a 2-wk exposure to hypobaric hypoxia and age-matched controls. alpha-Skeletal actin mRNA was increased greater than 10-fold in the RV of hypertensive animals, whereas alpha-cardiac actin mRNA did not appear to change. alpha-Skeletal actin mRNA and alpha-cardiac actin mRNA did not increase in the LV of any of the hypoxic animals. After a 2-wk hypoxic exposure, calves were removed from the chamber. Two days later, RV alpha-skeletal actin mRNA decreased dramatically but was apparently elevated above that of an age-matched control. Thirty days after hypoxia, there appeared to be a persistent increase in RV alpha-skeletal actin mRNA. Although the physiological significance of these changes are unknown, an alteration in the RV myocyte phenotype has occurred.

Transient severe isolated right ventricular hypertrophy in neonates

2003 ◽  
Vol 13 (4) ◽  
pp. 384-386 ◽  
Author(s):  
Munesh Tomar ◽  
Sitaraman Radhakrishnan ◽  
Savitri Shrivastava
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Ventricular Function ◽  
Ventricular Hypertrophy ◽  
Pressure Overload ◽  
Posterior Wall ◽  
Right Ventricular Hypertrophy ◽  
Pulmonary Vasculature ◽  
Normal Thickness ◽  
The Right

We report two instances of transient isolated right-sided myocardial hypertrophy in patients with an intact ventricular septum, normal thickness of the posterior wall of the left ventricle, and normal ventricular function, diagnosed by echocardiography on the third day of life. The two neonates, born at 36 and 38 weeks gestation respectively, had perinatal distress. Both were diagnosed as having isolated right ventricular hypertrophy with mild pulmonary hypertension, which disappeared in both cases within 8 weeks without any specific therapy. Though the cause of the ventricular hypertrophy remains unclear, we believe that it is the consequence of remodeling of pulmonary vasculature secondary to acute perinatal distress, resulting in persistent pulmonary hypertension and producing pressure overload on the right ventricle, and hence right ventricular hypertrophy. The finding of early and transient right ventricular hypertrophy, with normal left-sided structures and normal ventricular function, has thus far failed to gain attention in the paediatric cardiologic literature.

scholarly journals Bosentan attenuates right ventricular hypertrophy and fibrosis in normobaric hypoxia model of pulmonary hypertension

2011 ◽  
Vol 30 (7) ◽  
pp. 827-833 ◽  
Author(s):  
Gaurav Choudhary ◽  
Frederick Troncales ◽  
Douglas Martin ◽  
Elizabeth O. Harrington ◽  
James R. Klinger
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy ◽  
Normobaric Hypoxia

scholarly journals Progressive Development of Pulmonary Hypertension Leading to Right Ventricular Hypertrophy Assessed by Echocardiography in Rats.

2003 ◽  
Vol 52 (4) ◽  
pp. 285-294 ◽  
Author(s):  
Yosuke KATO ◽  
Mitsunori IWASE ◽  
Hiroaki KANAZAWA ◽  
Natsuki KAWATA ◽  
Yukie YOSHIMORI ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy ◽  
Progressive Development

scholarly journals Cardiomyocyte-Specific Overexpression of HEXIM1 Prevents Right Ventricular Hypertrophy in Hypoxia-Induced Pulmonary Hypertension in Mice

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52522 ◽  
Author(s):  
Noritada Yoshikawa ◽  
Noriaki Shimizu ◽  
Takako Maruyama ◽  
Motoaki Sano ◽  
Tomohiro Matsuhashi ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy
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