Electronic properties investigation of human dihydrofolate reductase complexes with ligands

Author(s):  
Vladislav Naumovich ◽  
Maria Grishina ◽  
Jurica Novak ◽  
Prateek Pathak ◽  
Vladimir Potemkin ◽  
...  
Biochemistry ◽  
1990 ◽  
Vol 29 (40) ◽  
pp. 9467-9479 ◽  
Author(s):  
Jay F. Davies ◽  
Tavner J. Delcamp ◽  
Neal J. Prendergast ◽  
Victor A. Ashford ◽  
James H. Freisheim ◽  
...  

1984 ◽  
Vol 4 (10) ◽  
pp. 2010-2016 ◽  
Author(s):  
V L Funanage ◽  
T T Myoda ◽  
P A Moses ◽  
H R Cowell

Cells from a dihydrofolate reductase-deficient Chinese hamster ovary cell line were hybridized to human fetal skin fibroblast cells. Nineteen dihydrofolate reductase-positive hybrid clones were isolated and characterized. Cytogenetic and biochemical analyses of these clones have shown that the human dihydrofolate reductase (DHFR) gene is located on chromosome 5. Three of these hybrid cell lines contained different terminal deletions of chromosome 5. An analysis of the breakpoints of these deletions has demonstrated that the DHFR gene resides in the q11----q22 region.


2016 ◽  
Vol 70 ◽  
pp. 23-29 ◽  
Author(s):  
Sedat Karabulut ◽  
Natalia Sizochenko ◽  
Adnan Orhan ◽  
Jerzy Leszczynski

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