SYSTEMIC TYPE EPSTEIN-BARR VIRUS-RELATED LYMPHOPROLIFERATIVE DISEASES IN CHILDREN AND YOUNG ADULTS: Challenges for Pediatric Hemato-Oncologists and Infectious Disease Specialists

2007 ◽  
Vol 24 (8) ◽  
pp. 563-568 ◽  
Author(s):  
Shinsaku Imashuku
Keyword(s):  
Infectious Disease ◽  
Young Adults ◽  
Epstein Barr Virus ◽  
Lymphoproliferative Diseases ◽  
Barr Virus ◽  
Infectious Disease Specialists ◽  
Children And Young Adults ◽  
Epstein Barr

scholarly journals Epstein-Barr virus-associated acute pancreatitis

2019 ◽  
Vol 12 (11) ◽  
pp. e231744 ◽  
Author(s):  
Muhammad Baraa Hammami ◽  
Reem Aboushaar ◽  
Ahmad Musmar ◽  
Safa Hammami
Keyword(s):  
Acute Pancreatitis ◽  
Young Adults ◽  
Abdominal Pain ◽  
Epstein Barr Virus ◽  
Liver Enzymes ◽  
Moderate Severity ◽  
Barr Virus ◽  
Ebv Infection ◽  
Children And Young Adults ◽  
Epstein Barr

Epstein-Barr virus (EBV) infection is mostly subclinical and resolves spontaneously without complications. Gastroenterology involvement usually manifests as asymptomatic liver enzymes elevation. We report a new case of acute pancreatitis complicating EBV infection and review the literature. EBV-associated acute pancreatitis is rare, usually develops in the setting of clinically clear EBV infection, occurs mostly in children and young adults, has mild-to-moderate severity, and has excellent prognosis with conservative management. It should be suspected when patients with an EBV infection picture develop unexplained abdominal pain.

EBV+ Lymphoproliferative Diseases: Opportunities for leveraging EBV as a Therapeutic Target

Blood ◽  
2021 ◽  
Author(s):  
Keri Toner ◽  
Catherine M. Bollard
Keyword(s):  
Proliferative Response ◽  
Epstein Barr Virus ◽  
Human Tumor ◽  
Lymphoproliferative Disease ◽  
Lymphoproliferative Diseases ◽  
Malignant Lymphomas ◽  
Barr Virus ◽  
Immune Therapies ◽  
Tumor Virus ◽  
Epstein Barr

Epstein-Barr virus (EBV) is a ubiquitous human tumor virus, which contributes to the development of lymphoproliferative disease, most notably in patients with impaired immunity. EBV associated lymphoproliferation is characterized by expression of latent EBV proteins and ranges in severity from a relatively benign proliferative response to aggressive malignant lymphomas. The presence of EBV can also serve as a unique target for directed therapies for the treatment of EBV lymphoproliferative diseases, including T cell based immune therapies. In this review, we will describe the EBV-associated lymphoproliferative diseases and will particularly focus on the therapies that target EBV.

scholarly journals Cold agglutinins in infectious mononucleosis and heterophil-antibody- negative mononucleosis-like syndromes

Blood ◽  
1977 ◽  
Vol 50 (2) ◽  
pp. 195-202 ◽  
Author(s):  
CA Horwitz ◽  
J Moulds ◽  
W Henle ◽  
G Henle ◽  
H Polesky ◽  
...  
Keyword(s):  
Young Adults ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Control Group ◽  
Cold Agglutinins ◽  
Barr Virus ◽  
Epstein Barr

Abstract Cold agglutinins (CA) were evaluated prospectively in patients with various mononucleosis syndromes and in a large control group. Cold agglutinins with anti-i specificity were seen mainly in heterophil- positive or -negative Epstein-Barr virus (EBV)-induced infectious mononucleosis (31.8% of cases). Unclassified CA with equal reactivity against cord and adult erythrocytes were seen in 56 of 150 (37.3%) cases of heterophil-antibody-positive infectious mononucleosis (IM), in 1 of 7 (14.3%) cases of heterophil-negative EBV-induced IM, and in 12 of 31 (38.7%) cases of the heterophil-negative mononucleosis-like syndrome due to cytomegalovirus or other unspecified agents. One patient with heterophil-positive IM had a persistent, partially papain sensitive CA with anti-Pr-like activity. Anti-i CA were seen in less than 1.0% of healthy young adults (500) or patients without mononucleosis (500) submitted for heterophil studies. Unclassified CA were noted in 3.2% of the latter 1000 samples.

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