scholarly journals Inhibition of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with sulphonamides

2020 ◽  
Vol 36 (1) ◽  
pp. 329-334
Author(s):  
Linda J. Urbański ◽  
Andrea Angeli ◽  
Vesa P. Hytönen ◽  
Anna Di Fiore ◽  
Giuseppina De Simone ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Trichomonas Vaginalis ◽  
Protozoan Pathogen

scholarly journals Activation of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with amines and amino acids

2021 ◽  
Vol 36 (1) ◽  
pp. 758-763
Author(s):  
Andrea Angeli ◽  
Linda J. Urbański ◽  
Vesa P. Hytönen ◽  
Seppo Parkkila ◽  
Claudiu T. Supuran
Keyword(s):  
Amino Acids ◽  
Carbonic Anhydrase ◽  
Trichomonas Vaginalis ◽  
Protozoan Pathogen

Inhibition of the newly discovered β‑carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with inorganic anions and small molecules

2020 ◽  
Vol 213 ◽  
pp. 111274
Author(s):  
Linda J. Urbański ◽  
Andrea Angeli ◽  
Vesa P. Hytönen ◽  
Anna Di Fiore ◽  
Seppo Parkkila ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Small Molecules ◽  
Trichomonas Vaginalis ◽  
Inorganic Anions ◽  
Protozoan Pathogen

Beta-Carbonic Anhydrase 1 from Trichomonas Vaginalis as New Antiprotozoan Drug Target

2021 ◽  
Author(s):  
Claudiu T. Supuran ◽  
Anna Di Fiore ◽  
Seppo Parkkila ◽  
Giuseppina De Simone
Keyword(s):  
Carbonic Anhydrase ◽  
Drug Target ◽  
Trichomonas Vaginalis ◽  
Beta Carbonic Anhydrase ◽  
Carbonic Anhydrase 1

scholarly journals Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase from Trichomonas vaginalis

2020 ◽  
Vol 35 (1) ◽  
pp. 1292-1299 ◽  
Author(s):  
Linda J. Urbański ◽  
Anna Di Fiore ◽  
Latifeh Azizi ◽  
Vesa P. Hytönen ◽  
Marianne Kuuslahti ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Trichomonas Vaginalis ◽  
Structural Characterisation ◽  
Beta Carbonic Anhydrase

Trichomoniasis

2020 ◽  
pp. 1475-1477
Author(s):  
Jane Schwebke
Keyword(s):  
Trichomonas Vaginalis ◽  
Sexual Partners ◽  
Sexually Transmitted ◽  
Increased Risk ◽  
Protozoan Pathogen ◽  
Polymerase Chain ◽  
Conventional Microscopy ◽  
Hiv Acquisition ◽  
Risk Of Hiv Acquisition ◽  
Oral Metronidazole

Trichomonas vaginalis is a sexually transmitted protozoan pathogen that may cause more than one-half of all curable sexually transmitted genital infections worldwide. Women with trichomoniasis are often asymptomatic, but they may develop vaginal malodour, discharge, erythema, or itching, and their male or female sexual partners may also be infected, although urethritis in men is less likely to cause symptoms. Women with trichomoniasis have an increased risk of HIV acquisition, HIV shedding, pelvic inflammatory disease, and preterm birth. For diagnosis, rapid antigen detection, culture, and polymerase chain reaction methods have advantages over conventional microscopy, but are more expensive. Oral metronidazole is usually an effective treatment, with both sexual partners needing to be treated to prevent reinfection.

Trichomoniasis

2010 ◽  
pp. 1142-1144
Author(s):  
Sharon Hillier
Keyword(s):  
Trichomonas Vaginalis ◽  
Sexual Partners ◽  
Sexually Transmitted ◽  
Increased Risk ◽  
Protozoan Pathogen ◽  
Polymerase Chain ◽  
Conventional Microscopy ◽  
Hiv Acquisition ◽  
Risk Of Hiv Acquisition ◽  
Oral Metronidazole

Trichomonas vaginalis is a sexually transmitted protozoan pathogen that may cause more than one-half of all curable sexually transmitted genital infections worldwide. Women with trichomoniasis are often asymptomatic, but they may develop vaginal malodour, discharge, erythema, or itching, and their male or female sexual partners may also be infected, although urethritis in men is less likely to cause symptoms. Women with trichomoniasis have an increased risk of HIV acquisition, HIV shedding, pelvic inflammatory disease, and preterm birth. For diagnosis, rapid antigen detection, culture, and polymerase chain reaction (PCR) methods have advantages over conventional microscopy, but are more expensive. Oral metronidazole is usually an effective treatment, with both sexual partners needing to be treated to prevent reinfection....

Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease

2013 ◽  
Vol 21 (15) ◽  
pp. 4472-4476 ◽  
Author(s):  
Peiwen Pan ◽  
Alane Beatriz Vermelho ◽  
Andrea Scozzafava ◽  
Seppo Parkkila ◽  
Clemente Capasso ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Causative Agent ◽  
Protozoan Pathogen ◽  
Inhibition Studies

Silicon Substitution for Calcium in the Shell of the Fingernail Clam, Musculium Transversum Studied By X-Ray Analysis

1980 ◽  
Vol 38 ◽  
pp. 560-561
Author(s):  
Judith A. Murphy ◽  
Anthony Paparo ◽  
Richard Sparks
Keyword(s):  
Carbonic Anhydrase ◽  
River Water ◽  
Food Chains ◽  
Well Water ◽  
Shell Formation ◽  
X Ray ◽  
Molluscan Shell ◽  
Fingernail Clams

Fingernail clams (Muscu1ium transversum) are dominant bottom-dwelling animals in some waters of the midwest U.S. These organisms are key links in food chains leading from nutrients in water and mud to fish and ducks which are utilized by man. In the mid-1950’s, fingernail clams disappeared from a 100-mile section of the Illinois R., a tributary of the Mississippi R. Some factor(s) in the river and/or sediment currently prevent clams from recolonizing areas where they were formerly abundant. Recently, clams developed shell deformities and died without reproducing. The greatest mortality and highest incidence of shell deformities appeared in test chambers containing the highest proportion of river water to well water. The molluscan shell consists of CaCO3, and the tissue concerned in its secretion is the mantle. The source of the carbonate is probably from metabolic CO2 and the maintenance of ionized Ca concentration in the mantle is controlled by carbonic anhydrase. The Ca is stored in extracellular concentric spherical granules(0.6-5.5μm) which represent a large amount of inertCa in the mantle. The purpose of this investigation was to examine the role of raw river water and well water on shell formation in the fingernail clam.

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