Composition of fatty oils from Semen Ziziphi Spinosae and its cardiotonic effect on isolated toad hearts

2012 ◽  
Vol 26 (5) ◽  
pp. 479-483 ◽  
Author(s):  
Junbo Xie ◽  
Yanqing Zhang ◽  
Lijuan Wang ◽  
Wuqin Qi ◽  
Mingchun Zhang
Keyword(s):  
Cardiotonic Effect

scholarly journals Cardiotonic effect of a new positive inotropic agent, OPC-8212, on canine right-sided heart failure models

1984 ◽  
Vol 36 ◽  
pp. 276
Author(s):  
Keitaro Hashimoto ◽  
Toyoki Mori ◽  
Shuji Yamashita ◽  
Youichi Yabuuchi
Keyword(s):  
Heart Failure ◽  
Inotropic Agent ◽  
Failure Models ◽  
Cardiotonic Effect

Miniglucagon [glucagon-(19-29)] is a component of the positive inotropic effect of glucagon

1991 ◽  
Vol 260 (5) ◽  
pp. C993-C999 ◽  
Author(s):  
C. Pavoine ◽  
V. Brechler ◽  
A. Kervran ◽  
P. Blache ◽  
D. Le-Nguyen ◽  
...  
Keyword(s):  
Active Metabolite ◽  
Positive Inotropic Effect ◽  
Inotropic Effect ◽  
Heart Cells ◽  
Inotropic Action ◽  
Cell Contractility ◽  
Ventricular Cells ◽  
Heart Contraction ◽  
Cardiotonic Effect ◽  
Glucagon Concentration

Glucagon is well known for its cardiotonic effect, but its mechanism of action remains undetermined. In the present study, we showed that glucagon, under minimal degradation conditions, had no effect on the amplitude of contractility of beating chick embryo ventricular cells. This raised the question of the contribution of the active metabolite of glucagon, glucagon-(19-29), referred to as miniglucagon, to the positive inotropic effect of glucagon. Incubation of glucagon with heart cells led to its rapid conversion into miniglucagon, as measured by radioimmunoassay. Accumulation of the metabolite was maximal after 8 min and remained stable until 15 min. reaching 6% of the initial glucagon concentration. Bacitracin inhibited this processing of glucagon into miniglucagon. Miniglucagon, from 0.1 pM to 1 nM, exerted a potent negative inotropic action. The most striking observation was a 45% increase in the amplitude of cell contractility elicited by the combination of 30 nM glucagon with 1 nM miniglucagon. A similar effect was obtained when glucagon was replaced by a low concentration (75 microM) of 8-bromoadenosine 3',5'-cyclic monophosphate. We conclude that glucagon processing into miniglucagon may be essential for the positive inotropic effect of glucagon on heart contraction.

scholarly journals A Review on Phytochemistry and Pharmacology of Cortex Periplocae

2016 ◽  
Author(s):  
Yang Li ◽  
Jin Li ◽  
Kun Zhou ◽  
Jun He ◽  
Jun Cao ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Adverse Reaction ◽  
Cardiac Glycosides ◽  
Biological Activities ◽  
Pharmacological Effects ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal ◽  
Bioactive Ingredients ◽  
Cardiotonic Effect ◽  
Inflammatory Effect

Cortex Periplocae, as a traditional Chinese herbal medicine, has been widely used for autoimmune diseases, especially rheumatoid arthritis. Due to its potential pharmaceutical values, more studies about the biological activities of Cortex Periplocae have been conducted recently. Meanwhile, the adverse reaction of Cortex Periplocae is not a negligible problem in clinic. In this article, we reviewed a series of articles and summarized the recent studies of Cortex Periplocae in the areas of phytochemistry and pharmacology. More than 100 constituents have been isolated and identified from Cortex Periplocae, including steroids, cardiac glycosides, terpenoids, and fatty acid compounds. The crude extracts of Cortex Periplocae and its active compounds exhibit various biological activities, such as cardiotonic effect, anticancer action, and anti-inflammatory effect. This paper aims to provide an overall review on the bioactive ingredients, pharmacological effect, and toxicity of this plant. Furthermore, this review suggests investigating and developing new clinical usages according to the above pharmacological effects.

scholarly journals Repeated Aconitine Treatment Induced the Remodeling of Mitochondrial Function via AMPK–OPA1–ATP5A1 Pathway

2021 ◽  
Vol 12 ◽  
Author(s):  
Li-Zhen Qiu ◽  
Wei Zhou ◽  
Lan-Xin Yue ◽  
Yi-Hao Wang ◽  
Fei-Ran Hao ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Mitochondrial Function ◽  
Positive Inotropic Effect ◽  
Neonatal Rat ◽  
Inotropic Effect ◽  
Mitochondrial Morphology ◽  
Repeated Treatment ◽  
Α Subunit ◽  
Compound C ◽  
Cardiotonic Effect

Aconitine is attracting increasing attention for its unique positive inotropic effect on the cardiovascular system, but underlying molecular mechanisms are still not fully understood. The cardiotonic effect always requires abundant energy supplement, which is mainly related to mitochondrial function. And OPA1 has been documented to play a critical role in mitochondrial morphology and energy metabolism in cardiomyocytes. Hence, this study was designed to investigate the potential role of OPA1-mediated regulation of energy metabolism in the positive inotropic effect caused by repeated aconitine treatment and the possible mechanism involved. Our results showed that repeated treatment with low-doses (0–10 μM) of aconitine for 7 days did not induce detectable cytotoxicity and enhanced myocardial contraction in Neonatal Rat Ventricular Myocytes (NRVMs). Also, we first identified that no more than 5 μM of aconitine triggered an obvious perturbation of mitochondrial homeostasis in cardiomyocytes by accelerating mitochondrial fusion, biogenesis, and Parkin-mediated mitophagy, followed by the increase in mitochondrial function and the cellular ATP content, both of which were identified to be related to the upregulation of ATP synthase α-subunit (ATP5A1). Besides, with compound C (CC), an inhibitor of AMPK, could reverse aconitine-increased the content of phosphor-AMPK, OPA1, and ATP5A1, and the following mitochondrial function. In conclusion, this study first demonstrated that repeated aconitine treatment could cause the remodeling of mitochondrial function via the AMPK–OPA1–ATP5A1 pathway and provide a possible explanation for the energy metabolism associated with cardiotonic effect induced by medicinal plants containing aconitine.

Cardiotonic effect of digitalis in sinus rhythm during exercise

1986 ◽  
pp. 455-460 ◽  
Author(s):  
L. B. Tan ◽  
R. G. Murray ◽  
A. C. Tweddel ◽  
I. Hutton
Keyword(s):  
Sinus Rhythm ◽  
Cardiotonic Effect

Cardiotonic effect of Apocynum venetum L. extracts on isolated guinea pig atrium

2008 ◽  
Vol 63 (2) ◽  
pp. 111-116 ◽  
Author(s):  
Kaoru Irie ◽  
Takahiro Sato ◽  
Ippei Tanaka ◽  
Jun-ichiro Nakajima ◽  
Maiko Kawaguchi ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Apocynum Venetum ◽  
Guinea Pig Atrium ◽  
Cardiotonic Effect

scholarly journals Cardiotonic effect of quercetin on guinea-pig myocardium.

1991 ◽  
Vol 55 ◽  
pp. 403
Author(s):  
Kazumi Takeya ◽  
Masataka Itolgawa ◽  
Michio Yajima ◽  
Satoshi Suzuki ◽  
Hirohiko Nomura ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Cardiotonic Effect
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