Kavalactones isolated from Alpinia zerumbet (Pers.) Burtt. et Smith with protective effects against human umbilical vein endothelial cell damage induced by high glucose

2022 ◽  
pp. 1-7
Author(s):  
Hualin You ◽  
Min He ◽  
Di Pan ◽  
Guanqin Fang ◽  
Yan Chen ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
High Glucose ◽  
Cell Damage ◽  
Umbilical Vein ◽  
Protective Effects ◽  
Endothelial Cell Damage ◽  
Human Umbilical Vein ◽  
Alpinia Zerumbet

Protective effects of hyperoside against human umbilical vein endothelial cell damage induced by hydrogen peroxide

2012 ◽  
Vol 139 (2) ◽  
pp. 388-394 ◽  
Author(s):  
Zi-lin Li ◽  
Jin-cheng Liu ◽  
Jing Hu ◽  
Xiao-qiang Li ◽  
Si-wang Wang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Endothelial Cell ◽  
Cell Damage ◽  
Umbilical Vein ◽  
Protective Effects ◽  
Endothelial Cell Damage ◽  
Human Umbilical Vein

Abstract TP136: Cilostazol Inhibits Inflammation and Endothelial Cell Damage in Patients with Severe Carotid Disease

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Masako Yamazaki ◽  
Yoshikazu Okada ◽  
Akitsugu Kawashima ◽  
Koji Yamaguchi ◽  
Taku Yoneyama ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Adhesion Molecule ◽  
Cell Damage ◽  
Cellular Adhesion ◽  
Protective Effects ◽  
Endothelial Cell Damage ◽  
Carotid Disease ◽  
Markers Of Inflammation ◽  
Cellular Adhesion Molecule ◽  
Aspirin Group

Background: Cilostazol is an antiplatelet agent, which is known also to have protective effects on endothelial cell. We studied effects of cilostazol on markers of inflammation and endothelial cell damage in patients with severe carotid disease, who underwent carotid endoarterectomy (CEA). Methods: We measured high sensitivity CRP (hsCRP), soluble vascular cellular adhesion molecule (VCAM)-1, soluble E-selectin, soluble intercellular adhesion molecule-1 and von Willebrand Factor antigen (vWF) in 45 patients who underwent CEA (38 males and 7 females, mean age was 69 years). Venous blood was taken from each patient before (Pre) and 3 days (Day3), 10 days (Day10), 4 weeks and 1 year (Post) after CEA. Each marker was compared between patients who were treated with aspirin alone (aspirin group, 18 cases) and those treated with cilostazol alone or cilostazol plus aspirin (cilostazol group, 17 cases). Results: The levels of hsCRP, VCAM-1, E-selectin and vWF at Day3 and the levels of hsCRP and VCAM-1 on Day10 were significantly higher than those at PreCEA. The alterations of those markers were not significantly different between the aspirin and cilotazol groups. The levels of hsCRP in the cilostazol group were significantly lower than those in aspirin group at both PreCEA and PostCEA. The levels of VCAM-1 at PreCEA in the cilostazol group were significantly lower than those in the aspirin group. Conclusions: The results suggested that cilostazol inhibits inflammation and endothelial cell damage in patients with severe carotid disease, although its protective effects did not reduce the endothelial cell damage induced by CEA when compared with aspirin.

High glucose induced endothelial to mesenchymal transition in human umbilical vein endothelial cell

2017 ◽  
Vol 102 (3) ◽  
pp. 377-383 ◽  
Author(s):  
Chun-Hong Yu ◽  
Suriguga ◽  
Meng Gong ◽  
Wen-Juan Liu ◽  
Ning-Xuan Cui ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
High Glucose ◽  
Umbilical Vein ◽  
Mesenchymal Transition ◽  
Human Umbilical Vein ◽  
Endothelial To Mesenchymal Transition
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