The protective effect of prenatally administered vitamin E on behavioral alterations in an animal model of autism induced by valproic acid

Toxin Reviews ◽  
2020 ◽  
pp. 1-5
Author(s):  
Ahmad Alinaghi Langari ◽  
Akram Nejadi ◽  
Halimeh Kameshki ◽  
Sobhan Mohammadi Jorjafki ◽  
Yasamin Mirhosseini ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Animal Model ◽  
Vitamin E ◽  
Protective Effect ◽  
Behavioral Alterations

Protective effect of vitamin E on sperm motility and oxidative stress in valproic acid treated rats

2016 ◽  
Vol 95 ◽  
pp. 159-167 ◽  
Author(s):  
Giovana M. Ourique ◽  
Etiane M.H. Saccol ◽  
Tanise S. Pês ◽  
Werner G. Glanzner ◽  
Sun Hee Schiefelbein ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Valproic Acid ◽  
Vitamin E ◽  
Protective Effect ◽  
Sperm Motility ◽  
And Oxidative Stress

Protective effect of Vitamin E in an animal model of LPS-Induced inflammation

2002 ◽  
Vol 48 (3) ◽  
pp. 152-152
Author(s):  
A. Iborra ◽  
M. Mayorga ◽  
S. Estany ◽  
P. Martínez
Keyword(s):  
Animal Model ◽  
Vitamin E ◽  
Protective Effect

Protective Effect of Vitamin E in an Animal Model of LPS-Induced Inflammation

2004 ◽  
Vol 52 (6) ◽  
pp. 356-361 ◽  
Author(s):  
M. Mayorga ◽  
A. Iborra ◽  
S. Estany ◽  
P. Martínez
Keyword(s):  
Animal Model ◽  
Vitamin E ◽  
Protective Effect

Protective Effect of Vitamin E on Immune Triggered, Granulocyte Mediated Endothelial Injury

1984 ◽  
Vol 51 (01) ◽  
pp. 089-092 ◽  
Author(s):  
M A Boogaerts ◽  
J Van de Broeck ◽  
H Deckmyn ◽  
C Roelant ◽  
J Vermylen ◽  
...  
Keyword(s):  
Vitamin E ◽  
Protective Effect ◽  
Umbilical Vein ◽  
Endothelial Damage ◽  
Endothelial Injury ◽  
Mediated Effects ◽  
Anti Oxidant ◽  
Endothelial Cell Cultures ◽  
Vitro Model

SummaryThe effect of alfa-tocopherol on the cell-cell interactions at the vessel wall were studied, using an in vitro model of human umbilical vein endothelial cell cultures (HUEC). Immune triggered granulocytes (PMN) will adhere to and damage HUEC and platelets enhance this PMN mediated endothelial injury. When HUEC are cultured in the presence of vitamin E, 51Cr-leakage induced by complement stimulated PMN is significantly decreased and the enhanced cytotoxicity by platelets is completely abolished (p <0.001).The inhibition of PMN induced endothelial injury is directly correlated to a diminished adherence of PMN to vitamin E- cultured HUEC (p <0.001), which may be mediated by an increase of both basal and stimulated endogenous prostacyclin (PGI2) from alfa-tocopherol-treated HUEC (p <0.025). The vitamin E-effect is abolished by incubation of HUEC with the irreversible cyclo-oxygenase inhibitor, acetylsalicylic acid, but the addition of exogenous PGI2 could not reproduce the vitamin E-mediated effects.We conclude that vitamin E exerts a protective effect on immune triggered endothelial damage, partly by increasing the endogenous anti-oxidant potential, partly by modulating intrinsic endothelial prostaglandin production. The failure to reproduce vitamin E-protection by exogenously added PGI2 may suggest additional, not yet elucidated vitamin E-effects on endothelial metabolism.

scholarly journals Breeder Diet Strategies for Generating Ttpa-Null and Wild-Type Mice with Low Vitamin E Status to Assess Neurological Outcomes

2020 ◽  
Vol 4 (11) ◽  
Author(s):  
Katherine M Ranard ◽  
Matthew J Kuchan ◽  
John W Erdman
Keyword(s):  
Animal Model ◽  
Vitamin E ◽  
Mouse Model ◽  
Wild Type ◽  
Future Studies ◽  
Neurological Outcomes ◽  
Transfer Protein ◽  
And Function ◽  
The Brain ◽  
Vitamin E Status

ABSTRACT Studying vitamin E [α-tocopherol (α-T)] metabolism and function in the brain and other tissues requires an animal model with low α-T status, such as the transgenic α-T transfer protein (Ttpa)–null (Ttpa−/−) mouse model. Ttpa+/− dams can be used to produce Ttpa−/− and Ttpa+/+mice for these studies. However, the α-T content in Ttpa+/− dams’ diet requires optimization; diets must provide sufficient α-T for reproduction, while minimizing the transfer of α-T to the offspring destined for future studies that require low baseline α-T status. The goal of this work was to assess the effectiveness and feasibility of 2 breeding diet strategies on reproduction outcomes and offspring brain α-T concentrations. These findings will help standardize the breeding methodology used to generate the Ttpa−/− mice for neurological studies.

Recent advances in animal model experimentation in autism research

2013 ◽  
Vol 26 (5) ◽  
pp. 264-271 ◽  
Author(s):  
Mousumi Tania ◽  
Md. Asaduzzaman Khan ◽  
Kun Xia
Keyword(s):  
Animal Model ◽  
Animal Models ◽  
Human Condition ◽  
Behavioral Alterations ◽  
Important Place ◽  
Adult Mice ◽  
Recent Advances ◽  
Model Study ◽  
Disease Biology ◽  
Animal Model Study

ObjectiveAutism, a lifelong neuro-developmental disorder is a uniquely human condition. Animal models are not the perfect tools for the full understanding of human development and behavior, but they can be an important place to start. This review focused on the recent updates of animal model research in autism.MethodsWe have reviewed the publications over the last three decades, which are related to animal model study in autism.ResultsAnimal models are important because they allow researchers to study the underlying neurobiology in a way that is not possible in humans. Improving the availability of better animal models will help the field to increase the development of medicines that can relieve disabling symptoms. Results from the therapeutic approaches are encouraging remarkably, since some behavioral alterations could be reversed even when treatment was performed on adult mice. Finding an animal model system with similar behavioral tendencies as humans is thus vital for understanding the brain mechanisms, supporting social motivation and attention, and the manner in which these mechanisms break down in autism. The ongoing studies should therefore increase the understanding of the biological alterations associated with autism as well as the development of knowledge-based treatments therapy for those struggling with autism.ConclusionIn this review, we have presented recent advances in research based on animal models of autism, raising hope for understanding the disease biology for potential therapeutic intervention to improve the quality of life of autism individuals.

Protective effect of vitamin E on lymphocyte growth capacity during incubation in vitro

1995 ◽  
Vol 82 (2-3) ◽  
pp. 129-148 ◽  
Author(s):  
Ke-Yin Tu ◽  
Randall Matthews ◽  
Kathleen S. Matthews
Keyword(s):  
Vitamin E ◽  
Protective Effect ◽  
Growth Capacity ◽  
Lymphocyte Growth
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