Vulnerability to early stressful life events: The moderating role of HOMER1 gene in the gene × environment interaction

Author(s):  
Yidi Chen ◽  
Lizhong Wang ◽  
Dongdong Jiang ◽  
Shanshan Zhu ◽  
WeGene Research Team ◽  
...  
2009 ◽  
Vol 39 (9) ◽  
pp. 1407-1411 ◽  
Author(s):  
W. El Hage ◽  
J. F. Powell ◽  
S. A. Surguladze

Vulnerability to depression has been linked to the interaction of genetic predisposition with stressful life events. This review considers the associations between serotonergic and hypothalamic–pituitary–adrenal (HPA) systems. We follow the standpoint of a previous Editorial Review (Bhagwagar & Cowen, Psychological Medicine 2008, 38, 307–313) and consider another possible mechanism of vulnerability to depressive disorder, that is we suggest that the gene×environment interaction involves complex participation of serotonergic genes modulating response to stress through the HPA system.


Author(s):  
Melissa Julian ◽  
Huynh-Nhu Le ◽  
Mary Coussons-Read ◽  
Calvin J. Hobel ◽  
Christine Dunkel Schetter

2020 ◽  
Vol 119 ◽  
pp. 105005
Author(s):  
Catherine B. Stroud ◽  
Frances R. Chen ◽  
Blair Curzi ◽  
Douglas A. Granger ◽  
Leah D. Doane

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