Role of necroptosis of alveolar macrophages in acute lung inflammation of mice exposed to titanium dioxide nanoparticles

2022 ◽  
pp. 1-19
Author(s):  
Tomoya Sagawa ◽  
Akiko Honda ◽  
Raga Ishikawa ◽  
Natsuko Miyasaka ◽  
Megumi Nagao ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Alveolar Macrophages ◽  
Lung Inflammation ◽  
Titanium Dioxide Nanoparticles ◽  
Acute Lung Inflammation

Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice

2002 ◽  
Vol 282 (6) ◽  
pp. L1245-L1252 ◽  
Author(s):  
Ulrich a. Maus ◽  
M. Audrey Koay ◽  
Tim Delbeck ◽  
Matthias Mack ◽  
Monika Ermert ◽  
...  
Keyword(s):  
Alveolar Macrophages ◽  
Lung Inflammation ◽  
Intratracheal Instillation ◽  
Acute Lung Inflammation ◽  
Monocyte Chemoattractant ◽  
Lps Challenge ◽  
Inflammatory Conditions ◽  
Monocyte Recruitment ◽  
Lps Treatment

Intratracheal instillation of the monocyte chemoattractant JE/monocyte chemoattractant protein (MCP)-1 in mice was recently shown to cause increased alveolar monocyte accumulation in the absence of lung inflammation, whereas combined JE/MCP-1/lipopolysaccharide (LPS) challenge provoked acute lung inflammation with early alveolar neutrophil and delayed alveolar monocyte influx. We evaluated the role of resident alveolar macrophages (rAM) in these leukocyte recruitment events and related phenomena of lung inflammation. Depletion of rAM by pretreatment of mice with liposomal clodronate did not affect the JE/MCP-1-driven alveolar monocyte accumulation, despite the observation that rAM constitutively expressed the JE/MCP-1 receptor CCR2, as analyzed by flow cytometry and immunohistochemistry. In contrast, depletion of rAM largely suppressed alveolar cytokine release as well as neutrophil and monocyte recruitment profiles upon combined JE/MCP-1/LPS treatment. Despite this strongly attenuated alveolar inflammatory response, increased lung permeability was still observed in rAM-depleted mice undergoing JE/MCP-1/LPS challenge. Lung leakage was abrogated by codepletion of circulating neutrophils or administration of anti-CD18. Collectively, rAM are not involved in JE/MCP-1-driven alveolar monocyte recruitment in noninflamed lungs but largely contribute to the alveolar cytokine response and enhanced early neutrophil and delayed monocyte influx under inflammatory conditions (JE/MCP-1/LPS deposition). Loss of lung barrier function observed under these conditions is rAM independent but involves circulating neutrophils via β2-integrin engagement.

scholarly journals Induction of acute lung inflammation in mice with hemorrhagic shock and resuscitation: role of HMGB1

2014 ◽  
Vol 11 (1) ◽  
Author(s):  
Raymond LC Kao ◽  
Xuemei Xu ◽  
Anargyros Xenocostas ◽  
Neil Parry ◽  
Tina Mele ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Lung Inflammation ◽  
Acute Lung Inflammation

Oxidation of Polyunsaturated Lipid Membranes by Photocatalytic Titanium Dioxide Nanoparticles: Role of pH and Salinity

2020 ◽  
Vol 12 (29) ◽  
pp. 32446-32460 ◽  
Author(s):  
Elisa Parra-Ortiz ◽  
Sara Malekkhaiat Häffner ◽  
Thomas Saerbeck ◽  
Maximilian W. A. Skoda ◽  
Kathryn L. Browning ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Lipid Membranes ◽  
Titanium Dioxide Nanoparticles

scholarly journals Role of CD14 in a Mouse Model of Acute Lung Inflammation Induced by Different Lipopolysaccharide Chemotypes

PLoS ONE ◽  
2010 ◽  
Vol 5 (4) ◽  
pp. e10183 ◽  
Author(s):  
Adam A. Anas ◽  
Joppe W. R. Hovius ◽  
Cornelis van 't Veer ◽  
Tom van der Poll ◽  
Alex F. de Vos
Keyword(s):  
Mouse Model ◽  
Lung Inflammation ◽  
Acute Lung Inflammation

Stability and aggregation of silver and titanium dioxide nanoparticles in seawater: Role of salinity and dissolved organic carbon

2014 ◽  
Vol 33 (5) ◽  
pp. 1023-1029 ◽  
Author(s):  
Huanhua Wang ◽  
Robert M. Burgess ◽  
Mark G. Cantwell ◽  
Lisa M. Portis ◽  
Monique M. Perron ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Organic Carbon ◽  
Dissolved Organic Carbon ◽  
Titanium Dioxide Nanoparticles

scholarly journals Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement

2013 ◽  
Vol 110 (13) ◽  
pp. 5205-5210 ◽  
Author(s):  
T. Murata ◽  
K. Aritake ◽  
Y. Tsubosaka ◽  
T. Maruyama ◽  
T. Nakagawa ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Signal Enhancement ◽  
Acute Lung Inflammation ◽  
Therapeutic Application ◽  
Anti Inflammatory
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