Islet Cell Transplantation for Insulin-Dependent Diabetes

1995 ◽  
Vol 30 (6) ◽  
pp. 41-45 ◽  
Author(s):  
Paul E. Lacy
2017 ◽  
Vol 13 (2) ◽  
pp. 296-301
Author(s):  
Anbreen Iqbal ◽  
Muhammad Imran Qadir ◽  
Muhammad Asif

Diabetes is not one disease but rather is a heterogeneous group of syndromes characterized by an elevation of fasting blood glucose caused by a relative or absolute deficiency in insulin. The two main types of diabetes occur, type-1 is insulin dependent diabetes mellitus and type-2 is non insulin dependent diabetes mellitus. In type-1 body does not produce insulin and about 10% of all diabetic patients are affected. In type-2 diabetes imbalance of insulin and glucose occur and there are about 90% cases for type-2 diabetes. Gestational diabetes is also a type of diabetes and it is found mostly in women’s who are pregnant later such women’s are affected with type-2 diabetes and about 40% cases are studied. Different countries are affected at high level from diabetes. For the treatment of diabetes different techniques like insulin injection, oral vaccination, pancreas transplantation, transplantation of encapsulated islet cells, gene therapy technique and islet cell transplantation are used. All techniques have some advantages and disadvantages, but the encapsulated islet cell transplantation technique is promising with minimum complications. 


2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Mazhar A. Kanak ◽  
Morihito Takita ◽  
Faisal Kunnathodi ◽  
Michael C. Lawrence ◽  
Marlon F. Levy ◽  
...  

Islet cell transplantation is a promising beta cell replacement therapy for patients with brittle type 1 diabetes as well as refractory chronic pancreatitis. Despite the vast advancements made in this field, challenges still remain in achieving high frequency and long-term successful transplant outcomes. Here we review recent advances in understanding the role of inflammation in islet transplantation and development of strategies to prevent damage to islets from inflammation. The inflammatory response associated with islets has been recognized as the primary cause of early damage to islets and graft loss after transplantation. Details on cell signaling pathways in islets triggered by cytokines and harmful inflammatory events during pancreas procurement, pancreas preservation, islet isolation, and islet infusion are presented. Robust control of pre- and peritransplant islet inflammation could improve posttransplant islet survival and in turn enhance the benefits of islet cell transplantation for patients who are insulin dependent. We discuss several potent anti-inflammatory strategies that show promise for improving islet engraftment. Further understanding of molecular mechanisms involved in the inflammatory response will provide the basis for developing potent therapeutic strategies for enhancing the quality and success of islet transplantation.


Autoimmunity ◽  
1988 ◽  
Vol 1 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Desmond A. Schatz ◽  
Douglas J. Barrett ◽  
Noel K. Maclaren ◽  
William J. Riley

2008 ◽  
Vol 16 (2) ◽  
pp. 118-123 ◽  
Author(s):  
Tetsuya Ikemoto ◽  
Hirofumi Noguchi ◽  
Masayuki Shimoda ◽  
Bashoo Naziruddin ◽  
Andrew Jackson ◽  
...  

2021 ◽  
Author(s):  
Jia-Pu Liang ◽  
Robert P. Accolla ◽  
Madhuvanthi Soundirarajan ◽  
Amy Emerson ◽  
Maria M. Coronel ◽  
...  

2000 ◽  
Vol 9 (3) ◽  
pp. 409-414 ◽  
Author(s):  
Alessandra Rammcoli ◽  
Nicola Cautero ◽  
Camillo Ricordi ◽  
Michele Masetti ◽  
Ruth D. Molano ◽  
...  

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