scholarly journals Mechanical ventilation induces lung and brain injury through ATP production, P2Y1 receptor activation and dopamine release

Bioengineered ◽  
2022 ◽  
Vol 13 (2) ◽  
pp. 2346-2359
Author(s):  
Wei Wei ◽  
Zhentao Sun ◽  
Shifeng He ◽  
Wanyue Zhang ◽  
Sai Chen ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Brain Injury ◽  
Dopamine Release ◽  
Receptor Activation ◽  
P2y1 Receptor ◽  
Atp Production

scholarly journals Brain injury after 50 h of lung-protective mechanical ventilation in a preclinical model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Thiago G. Bassi ◽  
Elizabeth C. Rohrs ◽  
Karl C. Fernandez ◽  
Marlena Ornowska ◽  
Michelle Nicholas ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Brain Injury ◽  
Neuronal Damage ◽  
Normal Lung ◽  
Preclinical Model ◽  
Negative Consequences ◽  
Mechanically Ventilated ◽  
Protective Mechanical Ventilation ◽  
Hippocampal Apoptosis ◽  
Lung Protective Mechanical Ventilation

AbstractMechanical ventilation is the cornerstone of the Intensive Care Unit. However, it has been associated with many negative consequences. Recently, ventilator-induced brain injury has been reported in rodents under injurious ventilation settings. Our group wanted to explore the extent of brain injury after 50 h of mechanical ventilation, sedation and physical immobility, quantifying hippocampal apoptosis and inflammation, in a normal-lung porcine study. After 50 h of lung-protective mechanical ventilation, sedation and immobility, greater levels of hippocampal apoptosis and neuroinflammation were clearly observed in the mechanically ventilated group, in comparison to a never-ventilated group. Markers in the serum for astrocyte damage and neuronal damage were also higher in the mechanically ventilated group. Therefore, our study demonstrated that considerable hippocampal insult can be observed after 50 h of lung-protective mechanical ventilation, sedation and physical immobility.

scholarly journals Mechanical Ventilation Preserves Diaphragm Mitochondrial Function in a Rat Sepsis Model

2020 ◽  
Author(s):  
Pierre Eyenga ◽  
Damien Roussel ◽  
Benjamin Rey ◽  
Patrice Ndille ◽  
Loic Teulier ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Oxygen Consumption ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Oxidase Activity ◽  
Ros Generation ◽  
Mitochondrial Oxygen Consumption ◽  
Atp Production ◽  
Mitochondrial Ros ◽  
Mda Content

Abstract Background: To describe the effect of mechanical ventilation on diaphragm mitochondrial oxygen consumption, ATP production, reactive oxygen species (ROS) generation, and cytochrome-c oxidase activity and content, and their relationship to diaphragm strength in an experimental model of sepsis.Methods: A cecal ligation and puncture (CLP) protocol was performed in 12 rats while 12 controls underwent sham-operation. Half of the rats in each group were paralyzed and mechanically ventilated. We performed blood gas analysis and lactic acid assays 6 hours after surgery. Afterwards, we measured diaphragm strength and mitochondrial oxygen consumption, ATP and ROS generation, and cytochrome-c oxidase activity. We also measured malondialdehyde (MDA) content as an index of lipid peroxidation, and mRNA expression of the pro-inflammatory interleukin-1β (IL-1β) in diaphragms.Results: CLP rats showed severe hypotension, metabolic acidosis, and upregulation of diaphragm IL-1β mRNA expression. Compared to sham controls, spontaneously breathing CLP rats showed lower diaphragm force and increased susceptibility to fatigue, along with depressed mitochondrial oxygen consumption and ATP production and cytochrome-c oxidase activity. These rats also showed increased mitochondrial ROS generation and MDA content. Mechanical ventilation markedly restored mitochondrial oxygen consumption and ATP production in CLP rats; lowered mitochondrial ROS production by the complex 3; and preserved cytochrome-c oxidase activity.Conclusion: In an experimental model of sepsis, early initiation of mechanical ventilation restores diaphragm mitochondrial function.

scholarly journals Role of the Dopaminergic System in the Striatum and Its Association With Functional Recovery or Rehabilitation After Brain Injury

2021 ◽  
Vol 15 ◽  
Author(s):  
Antonio Verduzco-Mendoza ◽  
Paul Carrillo-Mora ◽  
Alberto Avila-Luna ◽  
Arturo Gálvez-Rosas ◽  
Adriana Olmos-Hernández ◽  
...  
Keyword(s):  
Brain Injury ◽  
Functional Recovery ◽  
Dopaminergic System ◽  
Brain Structures ◽  
Receptor Activation ◽  
Important Goal ◽  
Dopaminergic Drugs ◽  
Beneficial Effects ◽  
Severe Tbi

Disabilities are estimated to occur in approximately 2% of survivors of traumatic brain injury (TBI) worldwide, and disability may persist even decades after brain injury. Facilitation or modulation of functional recovery is an important goal of rehabilitation in all patients who survive severe TBI. However, this recovery tends to vary among patients because it is affected by the biological and physical characteristics of the patients; the types, doses, and application regimens of the drugs used; and clinical indications. In clinical practice, diverse dopaminergic drugs with various dosing and application procedures are used for TBI. Previous studies have shown that dopamine (DA) neurotransmission is disrupted following moderate to severe TBI and have reported beneficial effects of drugs that affect the dopaminergic system. However, the mechanisms of action of dopaminergic drugs have not been completely clarified, partly because dopaminergic receptor activation can lead to restoration of the pathway of the corticobasal ganglia after injury in brain structures with high densities of these receptors. This review aims to provide an overview of the functionality of the dopaminergic system in the striatum and its roles in functional recovery or rehabilitation after TBI.

Analysis of Risk Factors of Intracranial Infection After Traumatic Brain Injury Surgery

2021 ◽  
Vol 7 (5) ◽  
pp. 3161-3167
Author(s):  
JiNan Li ◽  
XinLi Zhang ◽  
Hang SU ◽  
YaNan Qu ◽  
MeiXuan Piao
Keyword(s):  
Risk Factors ◽  
Traumatic Brain Injury ◽  
Mechanical Ventilation ◽  
Cerebrospinal Fluid ◽  
Brain Injury ◽  
Operation Time ◽  
Cerebrospinal Fluid Leakage ◽  
Infection Group ◽  
Intracranial Infection ◽  
Indwelling Time

Background: Craniocerebral operation is the main method for the treatment of traumatic brain injury. However, it is very easy to be complicated with intracranial infection after operation, which affects the surgical efficacy and patient’s prognosis. It is also the main cause of surgical failure. It may also cause patient’s death for some patients with serious diseases. It is found that the infection after craniocerebral operation is often accompanied with abnormal changes of body-related treatment, in which the changes of serological indicators are more significant. Therefore, it is helpful to provide guidance for the prevention and judgment of patient’s postoperative infection by analyzing the patient’s serological indicators. Objective: To investigate the risk factors of intracranial infection and the levels of serum procalcitonin (PCT) and endothelin-1 (ET-1) in patients after traumatic brain injury. Methods: From January 2018 to January 2021, 58 patients with intracranial infection after traumatic brain injury (infection group) were selected, and 116 patients without intracranial infection after traumatic brain injury (non-infection group) were selected. The difference of clinical data between the two groups was analyzed. Serum PCT and ET-1 levels were measured in the two groups. Results: In the infection group, admission GCS scoring <8 points, operation time ≥4h, indwelling time of drainage tube ≥ 2d, preoperative ALB <35g/ L, mechanical ventilation and cerebrospinal fluid leakage were 63.79%, 72.41%, 43.10%, 68.97%, 32.76% and 68.97% respectively, which were obviously higher than those in the non-infection group (P<0.05). Logistic regression analysis results showed that admission GCS scoring, operation time, indwelling time of drainage tube, preoperative ALB, mechanical ventilation and cerebrospinal fluid leakage were the influencing factors of intracranial infection after traumatic brain injury (OR = 0.712,1.556,1.451,0.641,1.954 and 1.667, P<0.05); serum PCT and ET-1 in the infection group were (0.83 ± 0.20) mg/L and (0.87 ± 0.23) ng/L, respectively, which were significantly higher than those in the non-infection group (P<0.05); serum PCT and ET-1 in patients with different sex, age and pathogen had no significant difference (P>0.05); serum PCT and ET-1 area under ROC curve were 0.828 and 0.751, respectively P<0.05. Conclusion: The intracranial infection of patients with traumatic brain injury are affected by many factors including, admission GCS scoring, operation time, and so on, the levels of serum PCT and ET-1 in patients with intracranial infection are increased, which may be useful in predicting intracranial infection.

GABA B Receptor Activation Attenuates Neuronal Pyroptosis via the DDX3X/NLRP3 Pathway in Postcardiac Arrest Brain Injury

2021 ◽  
Author(s):  
Ye Sun ◽  
Jinying Li ◽  
Haikuo Wu ◽  
Ziwei Zhao ◽  
Youhai Jia ◽  
...  
Keyword(s):  
Brain Injury ◽  
Receptor Activation

scholarly journals Phasic Dopamine Release Evoked by Abused Substances Requires Cannabinoid Receptor Activation

2007 ◽  
Vol 27 (4) ◽  
pp. 791-795 ◽  
Author(s):  
J. F. Cheer ◽  
K. M. Wassum ◽  
L. A. Sombers ◽  
M. L. A. V. Heien ◽  
J. L. Ariansen ◽  
...  
Keyword(s):  
Dopamine Release ◽  
Cannabinoid Receptor ◽  
Receptor Activation

Clozapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation

1997 ◽  
Vol 338 (2) ◽  
pp. R3-R5 ◽  
Author(s):  
Hans Rollema ◽  
Yi Lu ◽  
Anne W Schmidt ◽  
Stevin H Zorn
Keyword(s):  
Prefrontal Cortex ◽  
Dopamine Release ◽  
Receptor Activation
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