scholarly journals Activating transcription factor 3-activated long noncoding RNA forkhead box P4-antisense RNA 1 aggravates colorectal cancer progression by regulating microRNA-423-5p/nucleus accumbens associated 1 axis

Bioengineered ◽  
2022 ◽  
Vol 13 (2) ◽  
pp. 2114-2129
Author(s):  
Zhouyang Cheng ◽  
Song Jiang ◽  
Ran Tao ◽  
Haipeng Ge ◽  
Jun Qin
Keyword(s):  
Colorectal Cancer ◽  
Transcription Factor ◽  
Nucleus Accumbens ◽  
Cancer Progression ◽  
Antisense Rna ◽  
Noncoding Rna ◽  
Activating Transcription Factor 3 ◽  
Forkhead Box ◽  
Activating Transcription Factor ◽  
Colorectal Cancer Progression

scholarly journals ASBEL–TCF3 complex is required for the tumorigenicity of colorectal cancer cells

2016 ◽  
Vol 113 (45) ◽  
pp. 12739-12744 ◽  
Author(s):  
Kenzui Taniue ◽  
Akiko Kurimoto ◽  
Yasuko Takeda ◽  
Takeshi Nagashima ◽  
Mariko Okada-Hatakeyama ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Transcription Factor ◽  
Cancer Cells ◽  
Noncoding Rna ◽  
Cancer Development ◽  
Activating Transcription Factor 3 ◽  
Colorectal Cancer Cells ◽  
Activating Transcription Factor ◽  
Atf3 Expression ◽  
Transcription Factor 3

Wnt/β-catenin signaling plays a key role in the tumorigenicity of colon cancer. Furthermore, it has been reported that lncRNAs are dysregulated in several steps of cancer development. Here we show that β-catenin directly activates the transcription of the long noncoding RNA (lncRNA) ASBEL [antisense ncRNA in the ANA (Abundant in neuroepithelium area)/BTG3 (B-cell translocation gene 3) locus] and transcription factor 3 (TCF3), both of which are required for the survival and tumorigenicity of colorectal cancer cells. ASBEL interacts with and recruits TCF3 to the activating transcription factor 3 (ATF3) locus, where it represses the expression of ATF3. Furthermore, we demonstrate that ASBEL–TCF3–mediated down-regulation of ATF3 expression is required for the proliferation and tumorigenicity of colon tumor cells. ATF3, in turn, represses the expression of ASBEL. Our results reveal a pathway involving an lncRNA and two transcription factors that plays a key role in Wnt/β–catenin–mediated tumorigenesis. These results may provide insights into the variety of biological and pathological processes regulated by Wnt/β-catenin signaling.

Long noncoding RNA CMPK2 promotes colorectal cancer progression by activating the FUBP3–c-Myc axis

Oncogene ◽  
2020 ◽  
Vol 39 (19) ◽  
pp. 3926-3938 ◽  
Author(s):  
Qingzu Gao ◽  
Rui Zhou ◽  
Yuan Meng ◽  
Rongfei Duan ◽  
Ling Wu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Colorectal Cancer Progression

scholarly journals The Long Noncoding RNA HOTAIR Promotes Colorectal Cancer Progression by Sponging miR-197

2018 ◽  
Vol 26 (3) ◽  
pp. 473-481 ◽  
Author(s):  
Xinyang Lu ◽  
Zhiqiang Liu ◽  
Xiaofei Ning ◽  
Lunhua Huang ◽  
Biao Jiang
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Migration And Invasion ◽  
Downstream Target ◽  
Potential Applications ◽  
Colorectal Cancer Progression

The long noncoding RNA HOX transcript antisense RNA (HOTAIR) has been found to be overexpressed in many human malignancies and involved in tumor progression and metastasis. Although the downstream target through which HOTAIR modulates tumor metastasis is not well known, evidence suggests that microRNA-197 (miR-197) might be involved in this event. In the present study, the significance of HOTAIR and miR-197 in the progression of colorectal cancer was detected in vitro and in vivo. We found that HOTAIR expression was significantly increased in colorectal cancer cells and tissues. In contrast, the expression of miR-197 was obviously decreased. We further demonstrated that HOTAIR knockdown promoted apoptosis and inhibited cell proliferation, migration, and invasion in vitro and in vivo. Moreover, HOTAIR modulated the progression of colorectal cancer by competitively binding miR-197. Taken together, our study has identified a novel pathway through which HOTAIR exerts its oncogenic role and provided a molecular basis for potential applications of HOTAIR in the prognosis and treatment of colorectal cancer.

scholarly journals Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression

Oncotarget ◽  
2015 ◽  
Vol 6 (37) ◽  
pp. 39941-39959 ◽  
Author(s):  
Konstantinos Stamatakis ◽  
Marta Jimenez-Martinez ◽  
Alba Jimenez-Segovia ◽  
Isabel Chico-Calero ◽  
Elisa Conde ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Transcription Factor ◽  
Prostaglandin E2 ◽  
Cancer Progression ◽  
Growth Response ◽  
Early Growth ◽  
Early Growth Response ◽  
Colorectal Cancer Progression ◽  
Early Growth Response 1

scholarly journals miR‑190b promotes colorectal cancer progression through targeting forkhead box protein P2

2019 ◽  
Author(s):  
Qiang Zhao ◽  
Chengkui Liu ◽  
Qing Cui ◽  
Xuerong Luan ◽  
Qingfeng Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Forkhead Box ◽  
Colorectal Cancer Progression

scholarly journals MicroRNA‑544 promotes colorectal cancer progression by targeting forkhead box O1

2017 ◽  
Author(s):  
Guo‑Dong Yao ◽  
Ya‑Feng Zhang ◽  
Peng Chen ◽  
Xiu‑Bao Ren
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Forkhead Box ◽  
Colorectal Cancer Progression

scholarly journals Long Noncoding RNA LINC00460 Facilitates Colorectal Cancer Progression by Negatively Regulating miR-613

2020 ◽  
Vol Volume 13 ◽  
pp. 7555-7569
Author(s):  
Lei Wang ◽  
Xinxin Chen ◽  
xuan sun ◽  
Jian Suo
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Colorectal Cancer Progression
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