scholarly journals Role of the nitric oxide-soluble guanylyl cyclase pathway in cognitive deficits in streptozotocin-induced diabetic rats

2018 ◽  
Vol 29 (1) ◽  
pp. 34-44
Author(s):  
Yusufhan Yazir ◽  
Selen Polat ◽  
Tijen Utkan ◽  
Feyza Aricioglu
Keyword(s):  
Nitric Oxide ◽  
Cognitive Deficits ◽  
Guanylyl Cyclase ◽  
Soluble Guanylyl Cyclase ◽  
Diabetic Rats

scholarly journals Role of the nitric oxide–soluble guanylyl cyclase pathway in obstructive airway diseases

2014 ◽  
Vol 29 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Lisa L. Dupont ◽  
Constantinos Glynos ◽  
Ken R. Bracke ◽  
Peter Brouckaert ◽  
Guy G. Brusselle
Keyword(s):  
Nitric Oxide ◽  
Guanylyl Cyclase ◽  
Soluble Guanylyl Cyclase ◽  
Airway Diseases ◽  
Obstructive Airway Diseases

scholarly journals Role of central glutamate receptors, nitric oxide and soluble guanylyl cyclase in the inhibition by endotoxin of rat gastric acid secretion

2000 ◽  
Vol 130 (6) ◽  
pp. 1283-1288 ◽  
Author(s):  
Eugenia García-Zaragozá ◽  
M Dolores Barrachina ◽  
Lucrecia Moreno ◽  
Juan V Esplugues
Keyword(s):  
Nitric Oxide ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Glutamate Receptors ◽  
Gastric Acid ◽  
Guanylyl Cyclase ◽  
Soluble Guanylyl Cyclase

scholarly journals Role of sulfhydryl-dependent dimerization of soluble guanylyl cyclase in relaxation of porcine coronary artery to nitric oxide

2011 ◽  
Vol 90 (3) ◽  
pp. 565-572 ◽  
Author(s):  
X. Zheng ◽  
L. Ying ◽  
J. Liu ◽  
D. Dou ◽  
Q. He ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Coronary Artery ◽  
Guanylyl Cyclase ◽  
Soluble Guanylyl Cyclase ◽  
Porcine Coronary Artery

scholarly journals Nitric Oxide-dependent Allosteric Inhibitory Role of a Second Nucleotide Binding Site in Soluble Guanylyl Cyclase

2005 ◽  
Vol 280 (12) ◽  
pp. 11513-11519 ◽  
Author(s):  
Fu-Jung Chang ◽  
Scott Lemme ◽  
Qian Sun ◽  
Roger K. Sunahara ◽  
Annie Beuve
Keyword(s):  
Nitric Oxide ◽  
Binding Site ◽  
Guanylyl Cyclase ◽  
Soluble Guanylyl Cyclase ◽  
Nucleotide Binding ◽  
Nucleotide Binding Site ◽  
Inhibitory Role

scholarly journals Role of Aging Versus the Loss of Estrogens in the Reduction in Vascular Function in Female Rats

Endocrinology ◽  
2008 ◽  
Vol 150 (1) ◽  
pp. 212-219 ◽  
Author(s):  
James P. Stice ◽  
Jason P. Eiserich ◽  
A. A. Knowlton
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Nitric Oxide Synthase ◽  
Vascular Smooth Muscle ◽  
Guanylyl Cyclase ◽  
Vascular Function ◽  
Soluble Guanylyl Cyclase ◽  
Female Rats ◽  
Oxide Synthase

Although aging is known to lead to increased vascular stiffness, the role of estrogens in the prevention of age-related changes in the vasculature remains to be elucidated. To address this, we measured vascular function in the thoracic aorta in adult and old ovariectomized (ovx) rats with and without immediate 17β-estradiol (E2) replacement. In addition, aortic mRNA and protein were analyzed for proteins known to be involved in vasorelaxation. Aging in combination with the loss of estrogens led to decreased vasorelaxation in response to acetylcholine and sodium nitroprusside, indicating either smooth muscle dysfunction and/or increased fibrosis. Loss of estrogens led to increased vascular tension in response to phenylephrine, which could be partially restored by E2 replacement. Levels of endothelial nitric oxide synthase and inducible nitric oxide synthase did not differ among the groups, nor did total nitrite plus nitrate levels. Old ovx exhibited decreased expression of both the α and β-subunits of soluble guanylyl cyclase (sGC) and had impaired nitric oxide signaling in the vascular smooth muscle. Immediate E2 replacement in the aged ovx prevented both the impairment in vasorelaxation, and the decreased sGC receptor expression and abnormal sGC signaling within the vascular smooth muscle. The combination of loss of estradiol and aging leads to increased constriction (phenylephrine) and decreased relaxation with nitric oxide. Reduced soluble guanylyl cyclase mediates these changes.

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