Effects of Celecoxib on High‐Sensitivity C‐Reactive Protein in Chronic Peritoneal Dialysis Patients

Renal Failure ◽  
2004 ◽  
Vol 26 (4) ◽  
pp. 381-384 ◽  
Author(s):  
Soon Bae Kim ◽  
Sang Hyun Kim ◽  
Jae Won Chang ◽  
Sang Koo Lee ◽  
Won Ki Min ◽  
...  
2007 ◽  
Vol 27 (4) ◽  
pp. 456-460 ◽  
Author(s):  
Soon Bae Kim ◽  
Su Hee Kim ◽  
Moo Song Lee ◽  
Jai Won Chang ◽  
Sang Koo Lee ◽  
...  

Sulodexide, a standardized extractive glycosaminoglycan containing 80% “fast moving” heparin and 20% dermatan sulfate, decreased plasma D-dimer, a marker of intravascular coagulation, and fibrinogen levels in chronic peritoneal dialysis patients. Blood levels of von Willebrand factor, lipid, and high-sensitivity C-reactive protein were not significantly changed. No bleeding episodes were reported. These results suggest that sulodexide was effective in partially reversing the thrombogenic coagulation profile without increasing the risk of bleeding.


Author(s):  
Benyong WANG ◽  
Chan GAO ◽  
Qi CHEN ◽  
Ming WANG ◽  
Xiao FEI ◽  
...  

Background: To detect the serum procalcitonin (PCT) levels of peritoneal dialysis (PD) patients. Methods: We analyzed the relationship between the PCT Level and dialysis adequacy. We studied 120 peritoneal dialysis patients without signs of infection in Affiliated Hangzhou First People's Hospital and 120 controls from Jan 2014 to Apr 2016. PCT and high sensitivity C-reactive protein (hs-CRP) were detected. 120 PD patients were divided into two groups according to the dialysis adequacy. A correlation analysis was processed between the PCT level and the total solute clearance (Kt/V). The value of PCT for identifying the dialysis adequacy in PD patients was assessed by ROC curve analysis. Results: PCT level in serum of PD group (0.29±0.24 ng/ml) was higher than that of the control group (0.02±0.01 ng/ml) (P<0.01). Compared with the inadequate dialysis group (0.5±0.37 ng/ml), the PCT Level of the adequate dialysis group (0.23±0.15 ng/ml) was lower (P<0.01). There were negative correlations between PCT and Kt/v(r=- 0.451), Prealbumin (PA) (r=-0.258), Glomerular Filtration Rate (eGFR; r=-0.280), while there was positive correlation between PCT and Hypersensitive c-reactive protein (r=0.458) (P<0.01). At a serum PCT cut-off value of 0.283 ng/ml, the sensitivity and specificity for identifying the dialysis adequacy in PD patients were 0.913 and 0.805 respectively. The serum levels of PCT in peritoneal dialysis patients were significantly higher than the levels in healthy controls. Conclusion: The serum level of PCT can be used as an indirect maker to evaluate the adequacy of dialysis.


PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e93063 ◽  
Author(s):  
Shou-Hsuan Liu ◽  
Yi-Jung Li ◽  
Hsin-Hsu Wu ◽  
Cheng-Chia Lee ◽  
Chan-Yu Lin ◽  
...  

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii633-iii635
Author(s):  
Ya-Chung Tian ◽  
Shou-Hsuan Liu ◽  
Yi-Jung Li ◽  
Hsin-Hsu Wu ◽  
Cheng-Chia Lee ◽  
...  

2009 ◽  
Vol 29 (2) ◽  
pp. 178-181 ◽  
Author(s):  
Kyung Min Kim ◽  
Hyun Woo Kim ◽  
Jang Han Lee ◽  
Jai Won Chang ◽  
Jung Sik Park ◽  
...  

Beraprost sodium, an orally active prostaglandin I2 analog with vasodilatory, cytoprotective, antiplatelet, antithrombotic, and anti-inflammatory effects, 120 μg daily for 8 weeks, decreased plasma D-dimer, a marker of intravascular coagulation, and von Willebrand factor, a marker for endothelial injury, in 100 chronic peritoneal dialysis patients. Total cholesterol, triglycerides, high-density lipoprotein, apolipoprotein A1, apolipoprotein B, albumin, prealbumin, fibrinogen, troponin-T, and high-sensitivity C-reactive protein levels were not changed. Three patients complained of headache and 1 patient experienced facial flushing; however, no serious adverse effects were observed. These results suggest that beraprost sodium is effective in partially reversing the thrombogenic coagulation profile and endothelial injury in chronic peritoneal dialysis patients.


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