scholarly journals Tumour control probability derived from dose distribution in homogeneous and heterogeneous models: assuming similar pharmacokinetics,125Sn–177Lu is superior to90Y–177Lu in peptide receptor radiotherapy

2012 ◽  
Vol 57 (13) ◽  
pp. 4263-4275 ◽  
Author(s):  
Stephan Walrand ◽  
François-Xavier Hanin ◽  
Stanislas Pauwels ◽  
François Jamar
2020 ◽  
Vol 70 (4) ◽  
pp. 127-134
Author(s):  
Leszek Hawrylewicz ◽  
Bogusław Maciejewski ◽  
Klaus Rudiger Trott ◽  
Andrzej Tukiendorf ◽  
Leszek Miszczyk ◽  
...  

2020 ◽  
Vol 59 (8) ◽  
pp. 918-925 ◽  
Author(s):  
Charlotte A. Espensen ◽  
Ane L. Appelt ◽  
Lotte S. Fog ◽  
Juliette Thariat ◽  
Anita B. Gothelf ◽  
...  

Author(s):  
J. E. Marsden

Abstract Aims: The aim of this work is to report on the tumour control probability (TCP) of a UK cohort of lung stereotactic ablative radiotherapy patients (n = 198) for a range of dose and fractionations common in the UK. Materials and methods: TCP values for 3 (54 Gy), 5 (55 and 60 Gy) and 8 (50 Gy) fraction (#) schemes were calculated with the linear-quadratic Marsden TCP model using the Biosuite software. Results: TCP values of 100% were computed for the 3 # and for 5 # (α/β = 10 Gy) cohorts; reduced to 99% (range 97–100) for the 5 # cohort only when an α/β of 20 Gy was used. The average TCP value for the 50 Gy in 8 # regime was 97% (range 92–99, α/β = 10 Gy) and 64% (range 48–79, α/β = 20 Gy). Statistical significant differences were observed between the α/β of 10 Gy versus 20 Gy groups and between all data grouped by fraction. Conclusion: TCPs achievable with current planning techniques in the UK have been presented. The ultra-conservative 50 Gy in 8 # scheme returns a significantly lower TCP than the other regimes.


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