Graph theory analysis of directed functional brain networks in major depressive disorder based on EEG signal

2020 ◽  
Vol 17 (2) ◽  
pp. 026010 ◽  
Author(s):  
Fatemeh Hasanzadeh ◽  
Maryam Mohebbi ◽  
Reza Rostami
Keyword(s):  
Major Depressive Disorder ◽  
Graph Theory ◽  
Depressive Disorder ◽  
Brain Networks ◽  
Eeg Signal ◽  
Theory Analysis ◽  
Major Depressive ◽  
Functional Brain ◽  
Functional Brain Networks ◽  
Graph Theory Analysis

scholarly journals Graph Theory Analysis of Functional Brain Networks and Mobility Disability in Older Adults

2014 ◽  
Vol 69 (11) ◽  
pp. 1399-1406 ◽  
Author(s):  
C. E. Hugenschmidt ◽  
J. H. Burdette ◽  
A. R. Morgan ◽  
J. D. Williamson ◽  
S. B. Kritchevsky ◽  
...  
Keyword(s):  
Older Adults ◽  
Graph Theory ◽  
Brain Networks ◽  
Theory Analysis ◽  
Mobility Disability ◽  
Functional Brain ◽  
Functional Brain Networks ◽  
Graph Theory Analysis

scholarly journals Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhiyun Yang ◽  
Lingyu Jian ◽  
Hui Qiu ◽  
Chaoqing Zhang ◽  
Song Cheng ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Large Scale ◽  
Suicide Attempts ◽  
Brain Networks ◽  
Major Depressive ◽  
Functional Connectome ◽  
Antidepressant Efficacy ◽  
Functional Brain Networks ◽  
Positive Valence

AbstractBrain function relies on efficient communications between distinct brain systems. The pathology of major depressive disorder (MDD) damages functional brain networks, resulting in cognitive impairment. Here, we reviewed the associations between brain functional connectome changes and MDD pathogenesis. We also highlighted the utility of brain functional connectome for differentiating MDD from other similar psychiatric disorders, predicting recurrence and suicide attempts in MDD, and evaluating treatment responses. Converging evidence has now linked aberrant brain functional network organization in MDD to the dysregulation of neurotransmitter signaling and neuroplasticity, providing insights into the neurobiological mechanisms of the disease and antidepressant efficacy. Widespread connectome dysfunctions in MDD patients include multiple, large-scale brain networks as well as local disturbances in brain circuits associated with negative and positive valence systems and cognitive functions. Although the clinical utility of the brain functional connectome remains to be realized, recent findings provide further promise that research in this area may lead to improved diagnosis, treatments, and clinical outcomes of MDD.

scholarly journals Disrupted intrinsic functional brain topology in patients with major depressive disorder

2021 ◽  
Author(s):  
Hong Yang ◽  
Xiao Chen ◽  
Zuo-Bing Chen ◽  
Le Li ◽  
Xue-Ying Li ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Brain Networks ◽  
Major Depressive ◽  
Mixed Effect ◽  
Whole Brain ◽  
Functional Brain ◽  
Local Efficiency ◽  
Topological Features ◽  
Global And Local

AbstractAberrant topological organization of whole-brain networks has been inconsistently reported in studies of patients with major depressive disorder (MDD), reflecting limited sample sizes. To address this issue, we utilized a big data sample of MDD patients from the REST-meta-MDD Project, including 821 MDD patients and 765 normal controls (NCs) from 16 sites. Using the Dosenbach 160 node atlas, we examined whole-brain functional networks and extracted topological features (e.g., global and local efficiency, nodal efficiency, and degree) using graph theory-based methods. Linear mixed-effect models were used for group comparisons to control for site variability; robustness of results was confirmed (e.g., multiple topological parameters, different node definitions, and several head motion control strategies were applied). We found decreased global and local efficiency in patients with MDD compared to NCs. At the nodal level, patients with MDD were characterized by decreased nodal degrees in the somatomotor network (SMN), dorsal attention network (DAN) and visual network (VN) and decreased nodal efficiency in the default mode network (DMN), SMN, DAN, and VN. These topological differences were mostly driven by recurrent MDD patients, rather than first-episode drug naive (FEDN) patients with MDD. In this highly powered multisite study, we observed disrupted topological architecture of functional brain networks in MDD, suggesting both locally and globally decreased efficiency in brain networks.

scholarly journals Effects of a Motor Imagery Task on Functional Brain Network Community Structure in Older Adults: Data from the Brain Networks and Mobility Function (B-NET) Study

2021 ◽  
Vol 11 (1) ◽  
pp. 118
Author(s):  
Blake R. Neyland ◽  
Christina E. Hugenschmidt ◽  
Robert G. Lyday ◽  
Jonathan H. Burdette ◽  
Laura D. Baker ◽  
...  
Keyword(s):  
Older Adults ◽  
Graph Theory ◽  
Community Structure ◽  
Resting State ◽  
Brain Networks ◽  
Brain Network ◽  
Functional Brain ◽  
Network Community ◽  
Functional Brain Networks ◽  
The Brain

Elucidating the neural correlates of mobility is critical given the increasing population of older adults and age-associated mobility disability. In the current study, we applied graph theory to cross-sectional data to characterize functional brain networks generated from functional magnetic resonance imaging data both at rest and during a motor imagery (MI) task. Our MI task is derived from the Mobility Assessment Tool–short form (MAT-sf), which predicts performance on a 400 m walk, and the Short Physical Performance Battery (SPPB). Participants (n = 157) were from the Brain Networks and Mobility (B-NET) Study (mean age = 76.1 ± 4.3; % female = 55.4; % African American = 8.3; mean years of education = 15.7 ± 2.5). We used community structure analyses to partition functional brain networks into communities, or subnetworks, of highly interconnected regions. Global brain network community structure decreased during the MI task when compared to the resting state. We also examined the community structure of the default mode network (DMN), sensorimotor network (SMN), and the dorsal attention network (DAN) across the study population. The DMN and SMN exhibited a task-driven decline in consistency across the group when comparing the MI task to the resting state. The DAN, however, displayed an increase in consistency during the MI task. To our knowledge, this is the first study to use graph theory and network community structure to characterize the effects of a MI task, such as the MAT-sf, on overall brain network organization in older adults.

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