scholarly journals Recording evoked potentials during deep brain stimulation: development and validation of instrumentation to suppress the stimulus artefact

2012 ◽  
Vol 9 (3) ◽  
pp. 036004 ◽  
Author(s):  
A R Kent ◽  
W M Grill
Keyword(s):  
Deep Brain Stimulation ◽  
Evoked Potentials ◽  
Brain Stimulation ◽  
Stimulus Artefact ◽  
Development And Validation ◽  
Deep Brain

scholarly journals Intraoperative Characterization of Subthalamic Nucleus-to-Cortex Evoked Potentials in Parkinson’s Disease Deep Brain Stimulation

2021 ◽  
Vol 15 ◽  
Author(s):  
Lila H. Levinson ◽  
David J. Caldwell ◽  
Jeneva A. Cronin ◽  
Brady Houston ◽  
Steve I. Perlmutter ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Evoked Potentials ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
High Frequency ◽  
Therapeutic Effects ◽  
Stn Dbs ◽  
Deep Brain

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a clinically effective tool for treating medically refractory Parkinson’s disease (PD), but its neural mechanisms remain debated. Previous work has demonstrated that STN DBS results in evoked potentials (EPs) in the primary motor cortex (M1), suggesting that modulation of cortical physiology may be involved in its therapeutic effects. Due to technical challenges presented by high-amplitude DBS artifacts, these EPs are often measured in response to low-frequency stimulation, which is generally ineffective at PD symptom management. This study aims to characterize STN-to-cortex EPs seen during clinically relevant high-frequency STN DBS for PD. Intraoperatively, we applied STN DBS to 6 PD patients while recording electrocorticography (ECoG) from an electrode strip over the ipsilateral central sulcus. Using recently published techniques, we removed large stimulation artifacts to enable quantification of STN-to-cortex EPs. Two cortical EPs were observed – one synchronized with DBS onset and persisting during ongoing stimulation, and one immediately following DBS offset, here termed the “start” and the “end” EPs respectively. The start EP is, to our knowledge, the first long-latency cortical EP reported during ongoing high-frequency DBS. The start and end EPs differ in magnitude (p < 0.05) and latency (p < 0.001), and the end, but not the start, EP magnitude has a significant relationship (p < 0.001, adjusted for random effects of subject) to ongoing high gamma (80–150 Hz) power during the EP. These contrasts may suggest mechanistic or circuit differences in EP production during the two time periods. This represents a potential framework for relating DBS clinical efficacy to the effects of a variety of stimulation parameters on EPs.

Deep Brain Stimulation Evoked Potentials May Relate to Clinical Benefit in Childhood Dystonia

2014 ◽  
Vol 7 (5) ◽  
pp. 718-726 ◽  
Author(s):  
Nasir H. Bhanpuri ◽  
Matteo Bertucco ◽  
Diana Ferman ◽  
Scott J. Young ◽  
Mark A. Liker ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Evoked Potentials ◽  
Brain Stimulation ◽  
Clinical Benefit ◽  
Deep Brain

scholarly journals Evoked potentials reveal neural circuits engaged by human deep brain stimulation

2020 ◽  
Vol 13 (6) ◽  
pp. 1706-1718
Author(s):  
Stephen L. Schmidt ◽  
David T. Brocker ◽  
Brandon D. Swan ◽  
Dennis A. Turner ◽  
Warren M. Grill
Keyword(s):  
Deep Brain Stimulation ◽  
Evoked Potentials ◽  
Brain Stimulation ◽  
Neural Circuits ◽  
Deep Brain

scholarly journals Measurement of Evoked Potentials During Thalamic Deep Brain Stimulation

2015 ◽  
Vol 8 (1) ◽  
pp. 42-56 ◽  
Author(s):  
Alexander R. Kent ◽  
Brandon D. Swan ◽  
David T. Brocker ◽  
Dennis A. Turner ◽  
Robert E. Gross ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Evoked Potentials ◽  
Brain Stimulation ◽  
Deep Brain

Somatosensory evoked potentials in children with dystonia help predict outcome from deep brain stimulation

2017 ◽  
Vol 21 ◽  
pp. e221
Author(s):  
V.M. McClelland ◽  
D. Fialho ◽  
D. Flexney-Briscoe ◽  
G.E. Holder ◽  
M.C. Elze ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Evoked Potentials ◽  
Brain Stimulation ◽  
Somatosensory Evoked Potentials ◽  
Deep Brain
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