A Comparative Study of the Effects of a Dipeptidyl Peptidase-IV Inhibitor and Sulfonylurea on Glucose Variability in Patients with Type 2 Diabetes with Inadequate Glycemic Control on Metformin

2013 ◽  
Vol 15 (10) ◽  
pp. 810-816 ◽  
Author(s):  
Hun-Sung Kim ◽  
Jeong-Ah Shin ◽  
Seung-Hwan Lee ◽  
Eun-Sook Kim ◽  
Jae-Hyoung Cho ◽  
...  
2012 ◽  
Vol 413 (11-12) ◽  
pp. 1020-1021 ◽  
Author(s):  
Luziane Potrich Bellé ◽  
Paula Eliete Rodrigues Bitencourt ◽  
Karine Santos De Bona ◽  
Rafael Noal Moresco ◽  
Maria Beatriz Moretto

Author(s):  
Emily C Soriano ◽  
James M Lenhard ◽  
Jeffrey S Gonzalez ◽  
Howard Tennen ◽  
Sy-Miin Chow ◽  
...  

Abstract Background Spouses often attempt to influence patients' diabetes self-care. Spousal influence has been linked to beneficial health outcomes in some studies, but to negative outcomes in others. Purpose We aimed to clarify the conditions under which spousal influence impedes glycemic control in patients with type 2 diabetes. Spousal influence was hypothesized to associate with poorer glycemic control among patients with high diabetes distress and low relationship quality. Methods Patients with type 2 diabetes and their spouses (N = 63 couples) completed self-report measures before patients initiated a 7-day period of continuous glucose monitoring. Mean glucose level and coefficient of variation (CV) were regressed on spousal influence, diabetes distress, relationship quality, and their two- and three-way interactions. Results The three-way interaction significantly predicted glucose variability, but not mean level. Results revealed a cross-over interaction between spousal influence and diabetes distress at high (but not low) levels of relationship quality, such that spousal influence was associated with less variability among patients with low distress, but more among those with high distress. Among patients with high distress and low relationship quality, a 1 SD increase in spousal influence predicted a difference roughly equivalent to the difference between the sample mean CV and a CV in the unstable glycemia range. Conclusions This was the first study to examine moderators of the link between spousal influence and glycemic control in diabetes. A large effect was found for glucose variability, but not mean levels. These novel results highlight the importance of intimate relationships in diabetes management.


2014 ◽  
Vol 18 (2) ◽  
pp. 113-125 ◽  
Author(s):  
Marie-Hélène Lafeuille ◽  
Amanda Melina Grittner ◽  
Jonathan Gravel ◽  
Robert A Bailey ◽  
Silas Martin ◽  
...  

2006 ◽  
Vol 11 (3) ◽  
pp. 525-539 ◽  
Author(s):  
Brian D Green ◽  
Peter R Flatt ◽  
Clifford J Bailey

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