Number of Needle Passes Does Not Correlate with the Diagnostic Yield of Renal Fine Needle Aspiration Cytology

Objectives The primary objective of this study was to retrospectively assess the diagnostic utility of feline renal fine-needle aspiration cytology by assessing diagnostic yield, cytologic characteristics and diagnostic accuracy. The secondary objective was to characterize ultrasonographic features of sampled kidneys to determine if they influenced diagnostic yield. Methods Slides, images and patient data were collected from the University of Minnesota Veterinary Medical Center database. Slides were designated as diagnostic or non-diagnostic. Non-diagnostic slides were used in calculating diagnostic yield and excluded from other analysis. Slides were evaluated for cytologic characteristics and assigned a single primary diagnosis. Ultrasound still images were evaluated for descriptive characteristics and characteristics of specific lesions were described. Cases with confirmatory testing were used to determine diagnostic sensitivity, specificity and positive and negative predictive values for detecting neoplasia. Results Of 96 cytologic submissions available for review, diagnostic yield was 68%; 48% of samples were at least moderately cellular. Of 87 cases with ultrasound data, kidneys showing subcapsular renal infiltrate, diffuse renal enlargement without pelvic dilation and infiltrative/nodular change were more likely to yield diagnostic samples. Of 12 confirmed cases, cytology was 100% sensitive and specific for the detection of neoplasia (four round-cell tumors and two carcinomas). Three cases with non-neoplastic histologic diagnoses were considered cytologically normal, two incorrectly diagnosed the pathology present, and one correctly diagnosed the pathology. While some imaging characteristics were more commonly seen in neoplastic vs non-neoplastic lesions, the sample size was insufficient for definitive correlation. Conclusions and relevance This is the first major analysis of feline ultrasound-guided renal fine-needle aspiration cytology. This technique generates adequate samples for interpretation at rates comparable to other soft tissues and is most useful in the diagnosis of neoplasia. Some imaging characteristics are indicative of the likelihood of obtaining an adequate sample for cytologic interpretation.

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Utility of Ultrasonographically Guided Fine Needle Aspiration Cytology in the Diagnosis of Hepatic Masses

International Journal of Innovative Research in Medical Science ◽

10.23958/ijirms/vol03-i11/465 ◽

2018 ◽

Vol 3 (11) ◽

Author(s):

Dr. Prema Saldanha, ◽

Dr. Thahseena Abdulla

Keyword(s):

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Diagnostic Yield ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Fine Needle ◽

Secondary Tumors ◽

Technological Advances ◽

Regenerative Nodules ◽

Needle Aspiration Cytology

Background: With technological advances in imaging, previously inaccessible lesions can now be safely sampled by Fine Needle Aspiration Cytology (FNAC) under radiological guidance. It is also possible to ensure a more accurate diagnostic yield often providing an unequivocal diagnosis in both neoplastic and nonneoplastic conditions. This study was done to assess the role of Ultrasonographic (USG) guided FNAC in the evaluation of hepatic masses. Methodology: USG-guided FNAC was done in patients with hepatic masses. The smears made were stained by the Papanicolaou stain and the cytological features were studied. Relevant clinical data and laboratory investigations which corroborated the diagnosis were recorded. Results: A total of 90 liver aspirates were included in the study. Out of these there were 29 cases of hepatocellular carcinoma. In all the cases except one, the serum alpha fetoprotein levels were found to be elevated. There were 49 cases of metastatic tumors, in which the primary site was not known in 15 cases. The morphology of these secondary tumors was that of an adenocarcinoma. In the remaining 34 cases the primary tumor was found in various organs including the lung, pancreas, stomach, small intestine, breast, ovary, oral cavity and thyroid. There were six non-neoplastic lesions including regenerative nodules, hydatid cyst, tuberculosis, and abscess. In six cases the material was inadequate for definite diagnosis. Conclusion: USG-guided FNAC is a rapid, inexpensive and relatively safe technique for making a cytological diagnosis. A high degree of accuracy due to precise localization of the needle can be achieved and requires close co-operation between the clinician, the radiologist and the pathologist.

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Systematic Review of the Effectiveness of Fine-Needle Aspiration and/or Core Needle Biopsy for Subclassifying Lymphoma

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2013-0674-ra ◽

2015 ◽

Vol 139 (2) ◽

pp. 245-251 ◽

Cited By ~ 49

Author(s):

John K. Frederiksen ◽

Meenal Sharma ◽

Carla Casulo ◽

W. Richard Burack

Keyword(s):

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Diagnostic Yield ◽

Needle Aspiration ◽

Lymph Node Biopsy ◽

World Health ◽

Aspiration Cytology ◽

Core Needle ◽

Fine Needle ◽

Needle Aspiration Cytology

Context The World Health Organization system for lymphoma classification relies on histologic findings from excisional biopsies. In contradistinction to expert guidelines, practitioners increasingly rely on fine-needle aspiration cytology and core needle biopsies rather than excisional biopsies to diagnose lymphomas. Objective To determine a rate at which fine-needle aspiration cytology and core needle biopsies, combined with flow cytometry and/or genetic techniques, can provide a diagnosis sufficient for optimal medical management of lymphoma. Data Sources The English-language literature on fine-needle aspiration cytology and core needle biopsies for lymphoma was reviewed to identify studies that provided interpretations of all specimens regardless of whether these were deemed diagnostic. Conclusions Forty-two studies (1989–2012) specified the lymphoma subtypes for each diagnosis or indicated a rate at which the methods failed to provide a diagnosis. The median rate at which fine-needle aspiration cytology and core needle biopsies yielded a subtype-specific diagnosis of lymphoma was 74%. Strictly adhering to expert guidelines, which state that follicular lymphoma cannot be graded by these techniques, decreased the diagnostic yield further to 66%. Thus, 25% to 35% of fine-needle aspirates and/or core biopsies of nodes must be followed by an excisional lymph node biopsy to fully classify lymphoma.

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Diagnostic yield of fine-needle aspiration cytology in HIV-infected patients with lymphadenopathy in the era of highly active antiretroviral therapy

International Journal of STD & AIDS ◽

10.1258/ijsa.2008.008074 ◽

2008 ◽

Vol 19 (8) ◽

pp. 553-556 ◽

Cited By ~ 17

Author(s):

S M Lowe ◽

G I Kocjan ◽

S G Edwards ◽

R F Miller

Keyword(s):

Antiretroviral Therapy ◽

Fine Needle Aspiration ◽

Highly Active Antiretroviral Therapy ◽

Fine Needle Aspiration Cytology ◽

Diagnostic Yield ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Fine Needle ◽

Highly Active ◽

Needle Aspiration Cytology

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A comparative study of fine needle aspiration cytology versus non aspiration technique in thyroid lesions

International Surgery Journal ◽

10.18203/2349-2902.isj20180336 ◽

2018 ◽

Vol 5 (2) ◽

pp. 483

Author(s):

Sasikumar M. N. ◽

Sam Christy Mammen ◽

Jacob P. Thomas

Keyword(s):

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Diagnostic Yield ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Fine Needle ◽

Aspiration Technique ◽

Needle Aspiration Cytology ◽

Thyroid Lesions

Background: Fine needle aspiration cytology (FNAC) is regarded as the gold standard investigation in the diagnosis of thyroid swellings. But often unsatisfactory specimen, especially mixed with blood, poses an obstacle in proper cytological interpretation. To overcome this problem, an alternative method of fine needle non aspiration cytology (FNNAC) technique was developed which, relies on the capillary pressure only to suck the cells inside the needle bore.Methods: Patients presenting with thyroid swellings from July 2008 to January 2009 were included in the study. 91 patients treated for thyroid lesions entered a prospective comparative evaluation of fine needle cytology with aspiration and non-aspiration techniques in thyroid. The thyroid swelling in every patient was sampled by both the aspiration as well as the non-aspiration technique by a single operator. Both procedures were done using 23G needles. Aspiration was done using a 10ml syringe. Both dry and wet smears were made and stained. All smears were interpreted by a cytologist without knowledge of the technique employed. Apart from the diagnosis, comments were made on the quality of the slides and three qualitative categories are created as unsuitable specimens, diagnostically adequate and diagnostically superior.Results: Non-neoplastic lesions accounted for 92.3%. They comprised mainly of nodular colloid goiter 53.84%, colloid nodules 29.6%, thyroiditis 8.79%, and one case of suppurative lesion. Out of the 7 neoplasms, 2 were follicular neoplasms, 1 was papillary carcinoma, 2 cases of Hurthle cell neoplasm and 1 cellular nodule in an MNG. Diagnostically superior material was obtained in 42 cases (46.15%) of the non-aspiration samples, as compared with 18 cases (19.78%) of aspiration samples which was statistically significant.Conclusions: The FNNAC produces better results in the form of a better quality of the cellularity and less field obscurity by blood. This technique should be used alone or in tandem with FNAC for better diagnostic yield.

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