Dissecting the Mechanism of Histone Deacetylase Inhibitors to Enhance the Activity of Zinc Finger Nucleases Delivered by Integrase-Defective Lentiviral Vectors

Alok V. Joglekar; Libby Stein; Michelle Ho; Megan D. Hoban; Roger P. Hollis; Donald B. Kohn

doi:10.1089/hum.2013.211

Dissecting the Mechanism of Histone Deacetylase Inhibitors to Enhance the Activity of Zinc Finger Nucleases Delivered by Integrase-Defective Lentiviral Vectors

Human Gene Therapy ◽

10.1089/hum.2013.211 ◽

2014 ◽

Vol 25 (7) ◽

pp. 599-608 ◽

Cited By ~ 12

Author(s):

Alok V. Joglekar ◽

Libby Stein ◽

Michelle Ho ◽

Megan D. Hoban ◽

Roger P. Hollis ◽

...

Keyword(s):

Histone Deacetylase ◽

Zinc Finger ◽

Histone Deacetylase Inhibitors ◽

Lentiviral Vectors ◽

Zinc Finger Nucleases

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Histone Deacetylase Inhibition Rescues Gene Knockout Levels Achieved with Integrase-Defective Lentiviral Vectors Encoding Zinc-Finger Nucleases

Human Gene Therapy Methods ◽

10.1089/hgtb.2013.107 ◽

2013 ◽

Vol 24 (6) ◽

pp. 399-411 ◽

Cited By ~ 16

Author(s):

Laetitia P.L. Pelascini ◽

Ignazio Maggio ◽

Jin Liu ◽

Maarten Holkers ◽

Toni Cathomen ◽

...

Keyword(s):

Histone Deacetylase ◽

Zinc Finger ◽

Gene Knockout ◽

Lentiviral Vectors ◽

Zinc Finger Nucleases ◽

Histone Deacetylase Inhibition

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286. Determining the Specificity of Zinc Finger Nucleases by Analyzing Insertion Site Distribution of Integrase Defective Lentiviral Vectors (IDLV) Trapped into DNA Double Strand Breaks

Molecular Therapy ◽

10.1016/s1525-0016(16)37727-9 ◽

2010 ◽

Vol 18 ◽

pp. S109

Keyword(s):

Zinc Finger ◽

Insertion Site ◽

Lentiviral Vectors ◽

Double Strand Breaks ◽

Zinc Finger Nucleases ◽

Dna Double Strand Breaks ◽

Strand Breaks ◽

Site Distribution

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54. Towards Safe Genetic Modification of Human Epidermal Stem Cells by Zinc Finger Nucleases and Integrase Defective Lentiviral Vectors

Molecular Therapy ◽

10.1016/s1525-0016(16)38412-x ◽

2009 ◽

Vol 17 ◽

pp. S22

Keyword(s):

Stem Cells ◽

Zinc Finger ◽

Genetic Modification ◽

Lentiviral Vectors ◽

Zinc Finger Nucleases ◽

Epidermal Stem Cells

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390. Non-Integrating Lentiviral Vectors for Efficient and Transient Delivery of Zinc Finger Nucleases and Donor Constructs for Site-Specific Gene Correction

Molecular Therapy ◽

10.1016/s1525-0016(16)36194-9 ◽

2012 ◽

Vol 20 ◽

pp. S152-S153

Keyword(s):

Zinc Finger ◽

Lentiviral Vectors ◽

Zinc Finger Nucleases ◽

Specific Gene ◽

Gene Correction ◽

Site Specific

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967. A Gene Targeting Strategy Based on Zinc Finger Nucleases and Integrase-Defective Lentiviral Vectors Allowing Functional Correction of a Wide Spectrum of Mutations Causing X-Linked SCID

Molecular Therapy ◽

10.1016/s1525-0016(16)40370-9 ◽

2008 ◽

Vol 16 ◽

pp. S360-S361

Keyword(s):

Gene Targeting ◽

Zinc Finger ◽

Wide Spectrum ◽

Lentiviral Vectors ◽

Zinc Finger Nucleases ◽

Functional Correction ◽

Targeting Strategy

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321. Efficient Gene Correction and Targeted Gene Addition in Human Stem Cells Using Engineered Zinc Finger Nucleases and Integrase-Defective Lentiviral Vectors

Molecular Therapy ◽

10.1016/s1525-0016(16)44527-2 ◽

2007 ◽

Vol 15 ◽

pp. S121

Keyword(s):

Stem Cells ◽

Zinc Finger ◽

Lentiviral Vectors ◽

Zinc Finger Nucleases ◽

Human Stem Cells ◽

Gene Correction ◽

Efficient Gene

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10. Targeted Transgene Integration in Epidermal Stem Cells by Zinc Finger Nucleases and Integrase-Defective Lentiviral Vectors

Molecular Therapy ◽

10.1016/s1525-0016(16)37451-2 ◽

2010 ◽

Vol 18 ◽

pp. S4

Keyword(s):

Stem Cells ◽

Zinc Finger ◽

Lentiviral Vectors ◽

Zinc Finger Nucleases ◽

Epidermal Stem Cells ◽

Transgene Integration

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303. Efficient Site-Specific Integration in Human Hematopoietic Stem and Progenitor Cells by Zinc Finger Nucleases and Integrase-Defective Lentiviral Vectors

Molecular Therapy ◽

10.1016/s1525-0016(16)36107-x ◽

2012 ◽

Vol 20 ◽

pp. S120

Keyword(s):

Progenitor Cells ◽

Zinc Finger ◽

Lentiviral Vectors ◽

Zinc Finger Nucleases ◽

Hematopoietic Stem ◽

Site Specific ◽

Site Specific Integration ◽

Stem And Progenitor Cells

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Lentiviral Vectors Encoding Zinc-Finger Nucleases Specific for the Model Target Locus HPRT1

Methods in Molecular Biology - Gene Correction ◽

10.1007/978-1-62703-761-7_12 ◽

2014 ◽

pp. 181-199 ◽

Cited By ~ 6

Author(s):

Laetitia P. L. Pelascini ◽

Manuel A. F. V. Gonçalves

Keyword(s):

Zinc Finger ◽

Lentiviral Vectors ◽

Zinc Finger Nucleases ◽

Target Locus

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271: The Potential Clinical Application of Histone Deacetylase Inhibitors on Androgen Independent Prostate Cancer

The Journal of Urology ◽

10.1016/s0022-5347(18)32538-2 ◽

2006 ◽

Vol 175 (4S) ◽

pp. 90-90

Author(s):

Zhengwang Zhang ◽

Jennifer Stanfield ◽

Jer-Tsong Hsieh

Keyword(s):

Prostate Cancer ◽

Histone Deacetylase ◽

Clinical Application ◽

Histone Deacetylase Inhibitors ◽

Potential Clinical Application ◽

Androgen Independent

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