Ten-Year Native Liver Survival Rate After Laparoscopic and Open Kasai Portoenterostomy for Biliary Atresia

2019 ◽  
Vol 29 (1) ◽  
pp. 121-125 ◽  
Author(s):  
Kin Wai Edwin Chan ◽  
Kim Hung Lee ◽  
Hei Yi Vicky Wong ◽  
Siu Yan Bess Tsui ◽  
Jennifer Wai Cheung Mou ◽  
...  
Keyword(s):  
Survival Rate ◽  
Biliary Atresia ◽  
Kasai Portoenterostomy ◽  
Native Liver ◽  
Native Liver Survival

scholarly journals The prognosis of type III biliary atresia with a hilar cyst on ultrasonography might not be better than that without

2019 ◽  
Author(s):  
Quan-yuan Shan ◽  
Bao-xian Liu ◽  
Zhi-hai Zhong ◽  
Hua-dong Chen ◽  
Yu Guo ◽  
...  
Keyword(s):  
Survival Rate ◽  
Biliary Atresia ◽  
Survival Curves ◽  
Type Iii ◽  
Kaplan Meier ◽  
Significant Difference ◽  
Native Liver ◽  
Eventual Outcome ◽  
Native Liver Survival ◽  
Better Than

Abstract Background Biliary atresia (BA) with a hilar cyst is an uncommon variant of BA that may be misunderstood to have a relatively favorable prognosis. Methods A single-center retrospective review of patients that matched BA with a hilar cyst (n=27) with BA without a cyst (n=27) over a 5-years period was done. All patients were diagnosed as type III BA by histologic examination and cholangiograms. Results There were no significant intergroup differences between baseline characteristics and outcomes after Kasai portoenterostomy surgery in two groups. The Kaplan–Meier survival curves showed no significant difference in cumulative native liver survival rate of the two groups (p = 0.584). Of the 27 BA patients with a hilar cyst, 8 were showed the cyst communicated with the gallbladder on cholangiograms, and Kaplan-Meier survival curves indicated that the cumulative native liver survival rate was significantly shorter (P=0.045) in them than those who the cyst was not communicated with the gallbladder. Conclusions Type III BA with a hilar cyst had no better prognosis compared with Type III BA without a cyst. A cyst communicated with the gallbladder may be associated with a poor eventual outcome for Type III BA with a hilar cyst.

Laparoscopic versus open Kasai portoenterostomy in infant with biliary atresia: a retrospective review on the 5-year native liver survival

2012 ◽  
Vol 28 (11) ◽  
pp. 1109-1113 ◽  
Author(s):  
Kin Wai E. Chan ◽  
Kim Hung Lee ◽  
Siu Yan B. Tsui ◽  
Yuen Shan Wong ◽  
Kit Yi K. Pang ◽  
...  
Keyword(s):  
Biliary Atresia ◽  
Retrospective Review ◽  
Kasai Portoenterostomy ◽  
Native Liver ◽  
Native Liver Survival

Stretching the Limit of Native Liver Survival in Biliary Atresia After Kasai Portoenterostomy – a 37-year Territory-wide Study

2021 ◽  
Author(s):  
Patrick Ho Yu Chung ◽  
Edwin Kin Wai Chan ◽  
Fanny Yeung ◽  
Albert Chi Yan Chan ◽  
Jennifer Wai Cheung Mou ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Liver Transplant ◽  
Biliary Atresia ◽  
Kasai Portoenterostomy ◽  
Term Survival ◽  
Native Liver ◽  
The Mean ◽  
Native Liver Survival

Abstract ObjectiveWe present a 37 years’ experience in the management of biliary atresia (BA) and discuss long-term complications after Kasai portoenterostomy (KPE).MethodsA retrospective territory-wide study from 1980 to 2017 on 231 patients with open KPE from three tertiary paediatric surgical centres was performed. The jaundice clearance (JC) rate, native liver survival (NLS) rate and complications were analyzed.ResultsThe mean follow up period was 15.4 +/- 6.2 years. Over 60% of patients remained JC within 2 years after KPE. Seventy patients (30.3%) received liver transplant (LT) at a median age of 6.2 years (range: 0.5 to 25 years). The NLS rates at 10, 20 and 30 years were 70.7%, 61.5% and 53.0% respectively with no significant change over the study period. The median bilirubin level among all native liver survivors (n=153) was 24 µmol/L (2 to 162 µmol/L). Portal hypertension (PHT) and recurrent cholangitis were found in 51.6% and 27.5% of them respectively.ConclusionWith a vigilant follow up program, more than 60% of BA patients could remain stable with the disease and achieve long term survival without LT. Although portal hypertension and recurrent cholangitis are common, they do not need to be the indications for LT if managed properly.

scholarly journals Biliary atresia screening in Shenzhen: implementation and achievements

2020 ◽  
Vol 105 (8) ◽  
pp. 720-723 ◽  
Author(s):  
Jiachen Zheng ◽  
Yongqin Ye ◽  
Bin Wang ◽  
Lihui Zhang
Keyword(s):  
Survival Rate ◽  
Biliary Atresia ◽  
Screening Programme ◽  
Age At Diagnosis ◽  
Considerable Influence ◽  
Kasai Procedure ◽  
Native Liver ◽  
The Government ◽  
Free Rate ◽  
Native Liver Survival

ObjectiveTo elaborate on the implementation and achievements of a biliary atresia (BA) screening programme in Shenzhen.MethodsIn 2015, we partnered with the government in Shenzhen and attached the stool colour card (SCC) to the health handbook for mothers and children. These handbooks have been distributed through official channels to every pregnant woman in Shenzhen since 1 January 2015. A total of 118 patients diagnosed with BA at Shenzhen Children’s Hospital were enrolled and divided into two cohorts based on their date of diagnosis: cohort A before and cohort B after introduction of screening. The cohorts were compared to evaluate differences in age at diagnosis, jaundice-free rate, 2-year native liver survival rate and so on.ResultsAfter the implementation of the screening programme, the age at diagnosis decreased from 81±12 to 56±15 days old (p<0.05), the incidence of postoperative complications decreased from 58.8% to 52.6% (p<0.05), the jaundice-free rate increased from 47.1% to 54.4% (p<0.05), and the 2-year native liver survival rate increased from 44.4% to 52.6% (p<0.05). The percentage of patients who underwent surgery increased from 68.0% to 83.8% (p<0.05).ConclusionIn Shenzhen, our screening programme led to earlier diagnoses and better prognoses. The latter resulted in an increased willingness to undergo the Kasai procedure. Through a hospital and government collaboration, this programme exerted a considerable influence, and guardians observed benefits with only a small cost of implementation. Our results may eventually help promote the widespread use of the SCC across the whole country.

scholarly journals Predictors of Successful Kasai Portoenterostomy and Survival with Native Liver at 2 Years in Infants with Biliary Atresia

2019 ◽  
Vol 9 (4) ◽  
pp. 453-459 ◽  
Author(s):  
Ruchika Kumar ◽  
Bikrant B. Lal ◽  
Vikrant Sood ◽  
Rajeev Khanna ◽  
Senthil Kumar ◽  
...  
Keyword(s):  
Biliary Atresia ◽  
Kasai Portoenterostomy ◽  
Native Liver ◽  
Survival With Native Liver

scholarly journals Long-Term Effects of Kasai Portoenterostomy for Biliary Atresia Treatment in Russia

Diagnostics ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 686
Author(s):  
Anna Degtyareva ◽  
Alexander Razumovskiy ◽  
Nadezhda Kulikova ◽  
Sergey Ratnikov ◽  
Elena Filippova ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Survival Rate ◽  
Biliary Atresia ◽  
Kasai Portoenterostomy ◽  
Critical Importance ◽  
Long Term Effects ◽  
Age Related

This prospective study enrolled 144 patients after surgical treatment of biliary atresia in early infancy. We analyzed the immediate effectiveness of the surgery and the age-related structure of complications in the up to 16-year follow-up. The immediate 2-year survival rate after the surgery constituted 49.5%. At the time of this writing, 17 of the patients had celebrated their 10th birthdays with good quality of life and no indications for transplantation of the liver. The obtained results underscore the critical importance of surgical correction of biliary atresia by Kasai surgery in the first 60 days of life and subsequent dynamic follow-up of patients for the purpose of the early detection and timely correction of possible complications.

scholarly journals Quantitative Liver Fibrosis Using Collagen Hybridizing Peptide to Predict Native Liver Survival in Biliary Atresia

2020 ◽  
Vol 70 (1) ◽  
pp. 87-92
Author(s):  
Catalina Jaramillo ◽  
Stephen L. Guthery ◽  
Amy Lowichik ◽  
Gregory Stoddard ◽  
Taegun Kim ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Biliary Atresia ◽  
Native Liver ◽  
Native Liver Survival

scholarly journals Relevant factors for early liver transplantation after Kasai portoenterostomy

2020 ◽  
Author(s):  
Liang Ge ◽  
Jianghua Zhan ◽  
Wei Gao ◽  
Shengqiao Zhao ◽  
Xiaodan Xu ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Regression Analysis ◽  
Risk Factor ◽  
Multiple Logistic Regression Analysis ◽  
Multiple Logistic Regression ◽  
Kasai Portoenterostomy ◽  
Native Liver ◽  
Native Liver Survival ◽  
Relevant Factors ◽  
Better Than

Abstract Background：To explore the relevant factors for early liver transplantation (LT) after Kasai portoenterostomy (KP).Methods：Retrospective analysis was performed for 200 children with biliary atresia, who underwent LT with hepatic failure after KP. According to the interval between KP and LT, they were divided into three groups: G1 (≤6-month), G2 (6-month~2-year) and G3 (>2-year). Gender, age of Kasai portoenterostomy, jaundice-clearance, cholangitis after KP and liver function indexes before LT were compared among the three groups.Results：The proportion of patients with age of KP (≤90-day) in G1 was lower than that in G3 (P=0.003). Jaundice-clearance occurred in 6 (7.6%), 26(28.6%) and 26 (86.7%) patients after KP in G1, G2 and G3 respectively (P<0.001). There were statistical differences in the incidence of early cholangitis, late cholangitis and repeated cholangitis among the three groups (P=0.035, <0.001 and 0.022). The native liver survival (NLS) rate of children at operation age >90-day was lower than that of children at operation age ≤90-day (P=0.002). The NLS rate of the children with jaundice-clearance after KP was significantly better than that of the children without jaundice-clearance (P<0.001). The NLS rate of the children with early cholangitis after operation was lower than that in children without early cholangitis (P=0.026). The NLS rate of patients of G2 and G3 with cholangitis after KP was lower than that in children without cholangitis (P=0.017). Multiple logistic regression analysis showed uncleared jaundice after KP was a risk factor for the NLS survival time in patients.Conclusion：The age of KP (>90-day), jaundice-unclear and early cholangitis could reduce the NLS time after KP, which were related to early liver transplantation. Jaundice-unclear was a risk factor for early liver transplantation.

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