scholarly journals Dietary glycemic index and load, measures of glucose metabolism, and body fat distribution in older adults

2005 ◽  
Vol 82 (3) ◽  
pp. 547-552 ◽  
Author(s):  
Nadine R Sahyoun ◽  
Amy L Anderson ◽  
Alka M Kanaya ◽  
Pauline Koh-Banerjee ◽  
Stephen B Kritchevsky ◽  
...  
2005 ◽  
Vol 82 (3) ◽  
pp. 547-552 ◽  
Author(s):  
Nadine R Sahyoun ◽  
Amy L Anderson ◽  
Alka M Kanaya ◽  
Pauline Koh-Banerjee ◽  
Stephen B Kritchevsky ◽  
...  

Author(s):  
Gertraud Maskarinec ◽  
Phyllis Raquinio ◽  
Bruce S. Kristal ◽  
Adrian A. Franke ◽  
Steven D. Buchthal ◽  
...  

2009 ◽  
Vol 297 (5) ◽  
pp. E1097-E1104 ◽  
Author(s):  
Regje M. E. Blümer ◽  
Marc van der Valk ◽  
Mariette Ackermans ◽  
Erik Endert ◽  
Mireille J. Serlie ◽  
...  

HIV-infected patients on antiretroviral therapy frequently develop changes in body fat distribution and disturbances in glucose metabolism, associated with reduced adiponectin levels. Because adiponectin, principally the high-molecular-weight (HMW) form, has insulin-sensitizing properties, we investigated the effects of an increase in adiponectin on glucose metabolism in HIV-lipodystrophy. In this randomized, double-blind, placebo-controlled trial, we included HIV-1-infected patients with severe lipoatrophy, with an undetectable viral load and who had received neither protease inhibitors nor stavudine for ≥6 mo. Patients were randomized to rosiglitazone [8 mg daily ( n = 8)] to increase adiponectin levels or placebo ( n = 5) for 16 wk. Peripheral glucose disposal, glucose production, and lipolysis were measured after an overnight fast and during a hyperinsulinemic-euglycemic clamp using stable isotopes. Body composition was assessed by computed tomography and dual-energy X-ray absorptiometry. Although body fat distribution was unaffected, rosiglitazone increased total plasma adiponectin levels by 107% ( P < 0.02) and the ratio of HMW to total adiponectin by 73% ( P < 0.001). In the placebo group, neither total adiponectin levels ( P = 0.62) nor the ratio of HMW to total adiponectin changed ( P = 0.94). The marked increase in adiponectin induced by rosiglitazone was not associated with significant changes in basal endogenous glucose production ( P = 0.90), basal lipolysis ( P = 0.90), insulin-mediated suppression of glucose production ( P = 0.17) and lipolysis ( P = 0.54) nor with changes in peripheral glucose disposal ( P = 0.13). Acknowledging the limited statistical power of our small study, these findings, if confirmed by larger studies, could question the importance of adiponectin in regulating glucose metabolism in HIV-lipodystrophy.


1988 ◽  
Vol 67 (4) ◽  
pp. 760-767 ◽  
Author(s):  
ALAN N. PEIRIS ◽  
MARK F. STRUVE ◽  
ROBERT A. MUELLER ◽  
MARTHA B. LEE ◽  
AHMED H. KISSEBAH

2015 ◽  
Vol 170 (3) ◽  
pp. 498-505.e2 ◽  
Author(s):  
Konstantinos N. Aronis ◽  
Na Wang ◽  
Caroline L. Phillips ◽  
Emelia J. Benjamin ◽  
Gregory M. Marcus ◽  
...  

Obesity ◽  
2010 ◽  
Vol 18 (12) ◽  
pp. 2354-2361 ◽  
Author(s):  
Annemarie Koster ◽  
Sari Stenholm ◽  
Dawn E. Alley ◽  
Lauren J. Kim ◽  
Eleanor M. Simonsick ◽  
...  

1994 ◽  
Vol 171 (4) ◽  
pp. 875-884 ◽  
Author(s):  
Mark B. Landon ◽  
Kwame Osei ◽  
Maureen Platt ◽  
Thomas O'Dorisio ◽  
Philip Samuels ◽  
...  

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