scholarly journals A Fatal Case of Pediatric Primary Myxoid Liposarcoma of the Orbit: A Rare Tumor in an Unusual Location Presenting with Widespread Metastasis

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S82-S82
Author(s):  
A Baqir ◽  
Q Xie
Keyword(s):  
Fatal Case ◽  
Myxoid Liposarcoma ◽  
Liver Parenchyma ◽  
Age Group ◽  
Shortness Of Breath ◽  
Autopsy Case ◽  
Superior Orbital Fissure ◽  
Cytoplasmic Vacuoles ◽  
Adipose Differentiation ◽  
Pleomorphic Cells

Abstract Introduction/Objective A liposarcoma is a tumor derived from primitive mesenchymal cells undergoing adipose differentiation. Liposarcomas are uncommon in childhood, representing only about 2% of childhood sarcomas. Among liposarcomas, is a very rare subtype, the so-called ‘pleomorphic myxoid liposarcoma’ which has extensive myxoid changes and scattered pleomorphic cells. Here we report an autopsy case of an extensively metastatic pleomorphic myxoid liposarcoma. Methods A 12 year-old, African-American boy presented in the ED with ascites and shortness of breath, who later expired despite resuscitation. Autopsy finding showed a primary lesion in the left superior orbital fissure with diffuse metastasis to liver, replacing most of the liver parenchyma (liver weigh 8500 g). Metastatic foci are also present in gallbladder, pancreas, large intestine, bilateral lungs, and inner and outer surfaces of cranium. Histologically, tumor at all sites shows similar morphology, revealing scattered pleomorphic lipoblasts and a myxoid background with arborizing vasculature. Lipoblasts show indented and distorted nuclei and cytoplasmic vacuoles. Immunohistochemically the tumor cells are immunoreactive for p16 (diffusely and strongly) (Figure, D) and S100 (weakly) and negative for AE1/AE3, myogenin, synaptophysin, GFAP, EMA, and CD34. FISH was negative for MDM2 and t(12;16)(q13;p11.2) FUS-DDIT3 rearrangement, ruling out conventional myxoid liposarcoma. Conclusion This case shows the aggressive nature of a poorly studied entity in an uncommon age group and emphasize the need to study childhood liposarcomas in more detail.

scholarly journals A Diagnostic Dilemma of Cryptogenic Organising Pneumonia

2012 ◽  
Vol 52 (188) ◽  
Author(s):  
K Gurung
Keyword(s):  
Steroid Therapy ◽  
Lung Biopsy ◽  
Early Recognition ◽  
Steroid Treatment ◽  
Age Group ◽  
Shortness Of Breath ◽  
Diagnostic Dilemma ◽  
Good Outcome ◽  
Lung Condition

Cryptogenic Organising Pneumonia is a rare lung condition, which has incidence of 6-9 cases per 1000,000 people with onset at age group between 50-60. The pathogenesis of this condition remains unknown. It mimics like pneumonia but has a good outcome with steroid treatment. Early recognition is very important and treatment with steroid therapy can save lives. This case highlights the unusual cause of shortness of breath due to COP and co existing incidental severe AS where we faced a diagnostic dilemma till lung biopsy was performed. Keywords: Cryptogenic organising pneumonia; Pneumonia.

scholarly journals Yield of Echocardiogram and Predictors of Positive Yield in Pediatric Patients: A Study in an Urban, Community-Based Outpatient Pediatric Cardiology Clinic

2018 ◽  
Vol 5 ◽  
pp. 2333794X1876914
Author(s):  
Ramya Deepthi Billa ◽  
Susan Szpunar ◽  
Lida Zeinali ◽  
Premchand Anne
Keyword(s):  
Pediatric Patients ◽  
Pediatric Cardiology ◽  
Age Group ◽  
Shortness Of Breath ◽  
Cumulative Yield ◽  
Community Based ◽  
Cardiology Clinic ◽  
First Time ◽  
Community Teaching ◽  
Echocardiographic Findings

The yield of outpatient echocardiograms varies based on the indication for the echocardiogram and the age of the patient. The purpose of this study was to determine the cumulative yield of outpatient echocardiograms by age group and reason for the test. A secondary aim was to determine the predictors of a positive echocardiogram in an outpatient cardiology clinic at a large community teaching hospital. We retrospectively reviewed the charts of 891 patients who had a first-time echocardiogram between 2011 and 2015. Positive yield was defined as echocardiographic findings that explained the reason for the echocardiogram. The overall positive yield was 8.2%. Children between birth and 3 months of age had the highest yield (34.2%), and children between 12 and 18 years of age had the lowest yield (1%). Patients with murmurs (18.1%) had the highest yield compared with patients with other signs or symptoms. By age group and reason, the highest yields were as follows: 0 to 3 months of age, murmur (39.2%); 4 to 11 months of age, >1 symptom (50%); and 1 to 5 years of age, shortness of breath (66.7%). Based on our study, the overall yield of echocardiograms in the outpatient pediatric setting is low. Age and symptoms should be considered before ordering an echocardiogram.

scholarly journals GAMBARAN GANGGUAN HEMOSTASIS PADA PENDERITA SIROSIS HATI YANG DI RAWAT DI RSUP PROF.DR.R.D.KANDOU PERIODE AGUSTUS 2013 – AGUSTUS 2015

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Garry G. Saragih ◽  
Bradley J. Waleleng ◽  
Harlinda Haroen
Keyword(s):  
Liver Cirrhosis ◽  
Liver Dysfunction ◽  
Blood Clotting ◽  
Secondary Data ◽  
Liver Parenchyma ◽  
Age Group ◽  
Common Cause ◽  
Bleeding Manifestation ◽  
Cirrhotic Patients ◽  
Hemostatic Disorder

Abstract: Liver cirrhosis is a chronic disease characterized by changes in the structure and architecture of the liver parenchyma resulting in liver dysfunction. One of the liver dysfunction is changes in metabolism of proteins that play a role in blood clotting hemostasis). Therefore, one of the complications often found in liver cirrhosis is bleeding. This study aimed to obtain the profile of hemostatic disorder of cirrchosis patients treated in Prof. Dr. R. D. Kandou Hospital Manado from August 2013 toAugust 2015. This was a retrospective descriptive study using the secondary data of the Medical Record. The results showed that there were 75 patients with liver cirrhosis; 34 (45.7%) had impaired hemostasis. The highest proportion of cirrhotic patients with hemostasis disorder was male (67.6%); age group of 51-65 years (55.8%); the most common cause was HBV infection (35.3%); the most often bleeding manifestation was melena (61.7%); and the most common cause of bleeding was esophageal varices (44.1%), prolongation of PT (86.7%) and of APTT (46.7%). Low level of platelets count occured in 85,2% of patients. Conclusion: Almost half of the patients with liver cirrhosis had hemostasis disorders. Prolongation of PT occurred in most of the patients, however, no significant APTT prolongation was found. Thrombocytopenia frequently occured in patients with liver cirrhosis associated with hemostasis disorders. Keywords: hemostatic disorder, PT, thrombocytopenia, cirrchosis  Abstrak: Sirosis hati adalah penyakit hati kronis dimana terjadi perubahan struktur dan arsitektur dari parenkim hati sehingga hati tidak dapat berfungsi dengan baik. Salah satu fungsi hati yang terganggu ialah metabolisme protein yang berperan dalam mengatur fungsi pembekuan darah (hemostasis). Salah satu komplikasi yang sering dijumpai pada sirosis hati adalah perdarahan. Penelitian inin menggunakan metode retrospektif dengan mengambil data sekunder di Instalasi Rekam Medik RSUP Prof. Dr. R. D. Kandou Manado. Dari hasil penelitian diperoleh pasien sirosis hati sebanyak 75 orang, dan 34 orang (45,7%) diantaranya mengalami gangguan hemostasis. Proporsi tertinggi pasien sirosis disertai gangguan hemostasis ialah laki-laki (67,6%); kelompok umur 51-65 tahun (55,8%); penyebab terbanyak infeksi HBV (35,3%); manifestasi perdarahan yang sering muncul ialah melena (61,7%) dengan penyebab perdarahan tersering adalah varises esofagus (44,1%); serta pemanjangan PT (86,7%) dan APTT (46,7%). Nilai trombosit dibawah normal (trombositopenia) terjadi pada 85,2% pasien. Simpulan: Hampir setengah pasien sirosis hati mengalami gangguan hemostasis. Pemanjangan PT terjadi pada sebagian besar pasien yang diperiksa sedangkan pemanjangan APTT tidak signifikan. Trombositopenia sering terjadi pada pasien sirosis hati disertai gangguan hemostasis. Kata kunci: Gangguan hemostasis, PT, trombositopenia, sirosis.

scholarly journals A Fatal Case of Iatrogenic Bilateral Pneumothorax after Acupuncture

2009 ◽  
Vol 16 (4) ◽  
pp. 262-264 ◽  
Author(s):  
CW Lam ◽  
CP Ng ◽  
CH Chung
Keyword(s):  
Fatal Case ◽  
Motor Neurone ◽  
Motor Neurone Disease ◽  
Shortness Of Breath ◽  
Bilateral Pneumothorax

We report a case of fatal iatrogenic pneumothorax after acupuncture. A patient with motor neurone disease presented with shortness of breath after acupuncture. Bilateral pneumothoraces were detected. Bilateral chest drains were inserted. However, the patient succumbed 41 days after admission. On reviewing the literature, pneumothorax was not uncommonly seen after acupuncture, and most patients recovered uneventfully. However, fatal cases still happened.

scholarly journals Recurrent metastatic breast cancer presenting with portal hypertension and pseudocirrhosis

2019 ◽  
Vol 12 (11) ◽  
pp. e231044 ◽  
Author(s):  
Maciej Adler ◽  
Ivan Tang ◽  
Michael William Gach ◽  
George MacFaul
Keyword(s):  
Breast Cancer ◽  
Hepatic Injury ◽  
Performance Status ◽  
Metastatic Breast ◽  
Abdominal Distension ◽  
Liver Parenchyma ◽  
Decompensated Cirrhosis ◽  
Nodular Regenerative Hyperplasia ◽  
Shortness Of Breath ◽  
History Of

We present a case of a 63-year-old woman with an acute history of abdominal distension and shortness of breath. She had no risk factors for liver disease though her prior medical history was positive for breast carcinoma, in remission for 14 years. Examination and investigations were initially consistent with decompensated cirrhosis, thought to be due to subclinical autoimmune hepatitis. Imaging revealed hepatic contour irregularity, atrophy of the liver parenchyma and numerous lesions highly suggestive for multifocal hepatocellular carcinoma. Surprisingly, tissue histology revealed no evidence of cirrhosis, but recurrence of breast cancer which had mimicked cirrhosis. Pseudocirrhosis may be indistinguishable from true cirrhosis without histopathology. It has previously been linked to chemotherapy-induced hepatic injury and nodular regenerative hyperplasia, although our case illustrates an uncommon pathophysiology. Pseudocirrhosis often represents a poor prognosis even with a good baseline performance status, and early involvement of palliative care specialists may be advisable.

scholarly journals COVID‐19 in Neonates: A Review

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Maryam Saeedi ◽  
Razieh Sangsari ◽  
Kayvan Mirnia
Keyword(s):  
Breast Milk ◽  
Amniotic Fluid ◽  
Vertical Transmission ◽  
Family Members ◽  
Nasopharyngeal Swab ◽  
Age Group ◽  
Shortness Of Breath ◽  
Temperature Instability ◽  
Robust Transmission

: Neonates are vulnerable to COVID-19 infection. Its estimated rate in this age group is unknown. There is a robust transmission of COVID-19 from human-to-human. The result of all COVID-19 PCR tests on the amniotic fluid, placenta, cord, and breast milk was negative. The nasopharyngeal swab test of COVID-19 PCR in 56% of neonates was positive. 46.6% of neonates were asymptomatic, and in the others, the most common symptoms were: shortness of breath, tachypnea, cough, apnea, temperature instability, tachycardia. The possibility of vertical transmission (maternal-fetal) of COVID-19 is unknown. Because the most infected neonates with COVID-19 are asymptomatic, the transmission of the disease to other family members is very likely.

Myxoid liposarcoma with pleomorphic cells: Report of two cases with molecular confirmation of FUS gene rearrangements

2016 ◽  
Vol 212 (11) ◽  
pp. 1067-1070
Author(s):  
Kazuyoshi Uchihashi ◽  
Atsuji Matsuyama ◽  
Masamichi Nakayama ◽  
Akio Sakamoto ◽  
Eisuke Shiba ◽  
...  
Keyword(s):  
Myxoid Liposarcoma ◽  
Gene Rearrangements ◽  
Pleomorphic Cells

A fatal case of cannabis body-packing: About an autopsy case report

2020 ◽  
Vol 74 ◽  
pp. 102033
Author(s):  
Sarra Ben Abderrahim ◽  
Meriem Gharbaoui ◽  
Mohamed Amine Zaara ◽  
Hana Harzallah ◽  
Mohamed Allouche
Keyword(s):  
Case Report ◽  
Fatal Case ◽  
Autopsy Case ◽  
Body Packing

scholarly journals A Case Report of Prilocaine-Induced Methemoglobinemia after Liposuction Procedure

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Birdal Yildirim ◽  
Ulku Karagoz ◽  
Ethem Acar ◽  
Halil Beydilli ◽  
Emine Nese Yeniceri ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Emergency Service ◽  
Age Group ◽  
Shortness Of Breath ◽  
Blood Gas ◽  
Medicine Department ◽  
Arterial Blood Gas ◽  
Adult Age ◽  
Methemoglobin Level ◽  
Arterial Blood

Prilocaine-induced methemoglobinemia is a rarely seen condition. In this paper, a case is presented with methemoglobinemia developed secondary to prilocaine use in a liposuction procedure, and the importance of this rarely seen condition is emphasized. A 20-year-old female patient presented with complaints of prostration, lassitude, shivering, shortness of breath, and cyanosis. It was learned that the patient underwent nearly 1000 mg prilocaine infiltration 8 hours priorly during a liposuction procedure. At admission, her blood pressure (130/80 mmHg), pulse rate (140 bpm), body temperature (36°C), and respiratory rate (40/min) were recorded. The patient had marked acrocyanosis. The arterial blood gas methemoglobin level was measured as 40%. The patient received oxygen therapy with a mask and was administered vitamin C in normal saline (500 mg tid), N-acetylcysteine (300 mg tid), and 50 mg 10% methylene blue in the intensive care unit of the internal medicine department. Methemoglobin level dropped down to 2% after her treatment with methylene blue and she was clinically cured and discharged 2 days later. Emergency service physicians should remember to consider methemoglobinemia when making a differential diagnosis between dyspnea and cyanosis developing after prilocaine infiltration performed for liposuctions in the adult age group.

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