scholarly journals Accuracy of the Milan System for Detecting Neoplastic vs Non-Neoplastic Salivary Gland Lesions: A Retrospective Review

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S40-S40
Author(s):  
N Fakhri ◽  
H Khokhar ◽  
Z Khreefa ◽  
M Shahmirzadi ◽  
R Bhalla
Keyword(s):  
Salivary Gland ◽  
Diagnostic Tool ◽  
Retrospective Review ◽  
Warthin’S Tumor ◽  
Diagnostic Challenge ◽  
Histologic Diagnosis ◽  
Maximum Utility ◽  
Warthin's Tumor

Abstract Introduction/Objective Overlapping morphology and heterogeneity of salivary gland tumors (SGT) poses a diagnostic challenge. FNA is commonly used diagnostic tool for evaluation of superficial and deep lesions of any site, but above limitations restrict its maximum utility. To standardize reporting and to address above limitations, Milan system (MS) of reporting salivary gland cytology, has been developed and implemented by labs. We conducted a retrospective study, applying MS to salivary gland lesions (SGL) to evaluate its accuracy and usefulness in discriminating between neoplastic and non-neoplastic conditions, and thus directing patient management (PM) Methods/Case Report 10 yr retrospective review was performed to include patients with FNA for SGL, cytology diagnosis categorized using MS, cytology-histology (CH) correlation performed, and patients’ charts reviewed for follow up. Attention given to diagnostic discrepancies between MS categories and the histologic diagnosis Results (if a Case Study enter NA) 152 patients (20-88yrs) were retrieved, peak incidence 40-49 yrs; M:F ratio 1.2:1. Distribution of the cases in the MS categories: Non-diagnostic (ND) 24, Non-neoplastic (NN) 33, Atypia of Undetermined Significance (AUS) 4, Neoplasm (N) 71, Suspicious for malignancy (SUN) 7, and Malignant (M) 10. 60 cases identified with follow-up histology, of which 51 cases were correlated, distributed as 4 ND, 4 NN, 0 AUS, 37 N, 3 SUN, and 3 M. The uncorrelated 9 cases were distributed as 4 ND due to scant sampling; 2 NN, histologically Warthin’s tumor and sialolipoma; 2 AUS, histologically basal cell neoplasm and infarcted Warthin’s tumor; 1 malignant, histologically cystic mucoepidermoid carcinoma; 0 cases for neoplastic and suspicious for malignancy categories Conclusion Milan System is a useful cytologic tool for diagnosing and segregating patients with salivary gland pathologies, however, our study shows MS to be more reliable diagnostic tool with higher accuracy (combined 98%) in N, SUN & M categories as compared to ND, NN & AUS categories (combined 50%)

Occurrence of Salivary Gland Tumours in Two Patients Treated with Biological Agents

2012 ◽  
Vol 25 (1) ◽  
pp. 297-300 ◽  
Author(s):  
M. Carlesimo ◽  
E. Mart ◽  
M. La Pietra ◽  
D. Orsini ◽  
G. Pranteda ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Causal Relationship ◽  
Biological Agents ◽  
Salivary Gland Tumors ◽  
Tnf Alpha ◽  
Warthin’S Tumor ◽  
Salivary Gland Tumours ◽  
Warthin's Tumor

We report two cases of salivary gland tumors arising in two psoriatic patients treated with an anti-TNF-alpha agent. A clear causal relationship could not be established, but the exceptional onset of a bilateral Warthin's tumor in one of these patients should be emphasized.

Warthin's Tumor-Associated Neoplasms: Report of Two Cases and Review of the Literature

1993 ◽  
Vol 72 (4) ◽  
pp. 264-273 ◽  
Author(s):  
Alain H. Shikhani ◽  
Lama T. Shikhani ◽  
Francis P. Kuhajda ◽  
Charles K. Allam
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Malignant Lymphoma ◽  
Histological Type ◽  
Warthin’S Tumor ◽  
Review Of The Literature ◽  
Warthin's Tumor ◽  
Other Neoplasms

The association of Warthin's tumor with another neoplasm of a different histological type in the same salivary gland is extremely rare. The literature includes 42 such cases to date. A case of malignant lymphoma developing within Warthin's tumor and another case of oncocytoma synchronous with Warthin's tumor in the same parotid gland are reported. The relation of Warthin's tumor to other neoplasms is discussed.

scholarly journals Diffuse Large B-Cell Lymphoma Arising in Warthin's Tumor: Case Study and Review of the Literature

2013 ◽  
Vol 47 (6) ◽  
pp. 579 ◽  
Author(s):  
Güliz Özkök ◽  
Funda Taşlı ◽  
Nazan Özsan ◽  
Rafet Öztürk ◽  
Hakan Postacı
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Warthin’S Tumor ◽  
Review Of The Literature ◽  
Large B Cell Lymphoma ◽  
Warthin's Tumor ◽  
Large B Cell

P953Smartphone monitor kardia: an effective diagnostic tool for paroxysmal palpitations

EP Europace ◽  
2020 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
P Frey ◽  
D Irles ◽  
A Dompnier ◽  
C Akret ◽  
C Delfanne
Keyword(s):  
Atrial Flutter ◽  
Diagnostic Tool ◽  
Ecg Monitoring ◽  
Diagnostic Challenge ◽  
Holter Ecg ◽  
Af Ablation ◽  
Therapeutic Consequences ◽  
Normal Heart Rate ◽  
Cardiac Rhythm Disturbance

Abstract Funding Acknowledgements no grants to declare OnBehalf not applicable Background : Paroxysmal palpitations are diagnostic challenge because the ECG and the 24-hour holter ECG monitoring without palpitations is usually normal. We report a 1 year experience of a new diagnostic tool for paroxysmal palpitations: the smartphone monitor Kardia®. Patients with paroxysmal palpitation and negative 24 hour holter ECG was ask to sent iECG during symptoms during the 1 month follow-up. Results Between January and December 2018, 20 patients have received Kardia®, mean age 40 years, the mean duration kardia-monitoring was 26 days. A total of 235 iECGs were sent by email, a median of 6 iECG/patients. 9 (45%) patients remained without rhythmic diagnosis (sinus rhythm, normal heart rate), 11 (55%) patients had at least one pathological iECG: 4 atrial fibrillation, 4 junctional tachycardia including 1 with paroxysmal pre-excitation, 2 atrial flutters. These diagnosis had therapeutic consequences: 2 AF ablations, 2 AF treated by antiarythmic drugs (AAD), 2 atrial flutters ablation, 1 ILR was implanted for absence of diagnosis with kardia®. The other patients without diagnosis at the time of palpitations were reassured on the absence of cardiac rhythm disturbance. Conclusion The purchase of 5 Kardia® as a new diagnostic tool for paroxtysmal palpitations is a reasonable investment for a cardiology derpartment, the diagnostic performance is higher than current standards (24 hours holters ECG monitoring), since it allows an arhythmic diagnosis in more than 50% of cases in 1 mounth. The main limitation is the selection of patients, most often young, who already have a smartphone and can send an email. patient age (years) duration (days) i-ECG sent number diagnosis treatment patient 1 23 11 3 AF AF ablation patient 3 51 23 7 AF AA Drugs patient 10 65 20 5 AF AA Drugs patient 11 35 29 6 SVT : AVNRT no ablation patient 12 48 22 27 atrial flutter flutter ablation patient 13 34 1 13 SVT : AVNRT no ablation patient 14 56 7 18 atrial flutter flutter ablation patient 15 59 21 80 AF and PVC AF Ablation patient 16 50 1 3 SVT : AVRT no ablation patient 17 28 28 2 SVT : AVNRT no ablation patient 19 49 35 8 PVC AA Drugs 1 year kardia experience : diagnosis performance in the 11/20 patients with abnormal iECG Abstract Figure. iECG : termination of SVT (patient 17)

scholarly journals Warthin's tumor of parotid gland: Surgery or follow-up? Diagnostic value of a decisional algorithm with functional MRI

2016 ◽  
Vol 97 (1) ◽  
pp. 37-43 ◽  
Author(s):  
S. Espinoza ◽  
A. Felter ◽  
D. Malinvaud ◽  
C. Badoual ◽  
G. Chatellier ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Functional Mri ◽  
Diagnostic Value ◽  
Warthin’S Tumor ◽  
Warthin's Tumor ◽  
Decisional Algorithm

Association of Mast Cells with Warthin’s Tumor in Fine Needle Aspirates of the Salivary Gland

1999 ◽  
Vol 43 (6) ◽  
pp. 1052-1058 ◽  
Author(s):  
Tadao K. Kobayashi ◽  
Masami Ueda ◽  
Toshihiro Nishino ◽  
Ryoji Kushima ◽  
Shigemi Nakajima ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Mast Cells ◽  
Warthin’S Tumor ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Warthin's Tumor

Cytologic Features of Lymphoepithelioma-Like Carcinoma Involving the Parotid: A Case Report

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S98-S98
Author(s):  
Fei Chen ◽  
Lopa Modi ◽  
Ronaldo Zamuco ◽  
Melissa Yee-Chang
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Rare Case ◽  
Salivary Gland Neoplasms ◽  
Acinic Cell Carcinoma ◽  
Warthin’S Tumor ◽  
Acinic Cell ◽  
Nasopharyngeal Biopsy ◽  
Warthin's Tumor

Abstract Fine-needle aspiration biopsies (FNABs) are a common modality used in the evaluation of salivary gland neoplasms. We present the cytologic and histologic features of a rare case of lymphoepithelioma-like carcinoma (LELC) in a 40-year-old Hispanic male with a 1.0-cm painless well-circumscribed parotid mass that had been present for 8 years. FNAB smears showed cohesive groups of intermediate-sized basaloid cells with vesicular nuclei, occasional pleomorphic nuclei and prominent nucleoli, and spindled morphology. Mature lymphocytes were seen in the background, either adjacent to the atypical epithelial cells or dispersed in the background. This lymphoid background raises considerations of salivary gland neoplasms that can have prominent lymphocytic backgrounds, such as acinic cell carcinoma and, more commonly, Warthin’s tumor or metastasis involving intraparotid lymph node. Surgical resection of the parotid showed syncytial sheets of predominantly undifferentiated cells with spindled to epithelioid morphology and occasional prominent nucleoli and focal areas of squamous differentiation. The background showed dense areas of lymphocytes with germinal center formation. Immunohistochemical (IHC) stains showed positive reactivity for p63, p40, and EBV in situ hybridization (EBV ISH) in the tumor cells and negative reactivity for p16. The findings were supportive of LELC if a metastasis from the nasopharynx was excluded. A subsequent nasopharyngeal biopsy was benign. Although histologic features of LELC are well established, we identified rare case reports describing the cytomorphology in the literature. Cytopathologists should be aware of this lesion as another salivary gland neoplasm that can show lymphocytes admixed with the tumor cells and a distinct lymphoid background. The basaloid appearance and cytologic atypia should distinguish it from acinic cell carcinoma and Warthin’s tumor. However, metastatic lesions should also be considered with a distinct lymphoid background and need to be clinically excluded before establishing the diagnosis of LELC.

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