scholarly journals Angiogenic Factors in Maternal Circulation and the Risk of Severe Fetal Growth Restriction

2011 ◽  
Vol 173 (6) ◽  
pp. 630-639 ◽  
Author(s):  
B. Olav Asvold ◽  
L. J. Vatten ◽  
P. R. Romundstad ◽  
P. A. Jenum ◽  
S. A. Karumanchi ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Angiogenic Factors ◽  
Growth Restriction ◽  
Maternal Circulation

Evaluating the Effect of Pravastatin in Early-Onset Fetal Growth Restriction: A Nonrandomized and Historically Controlled Pilot Study

2020 ◽  
Author(s):  
Manel Mendoza ◽  
Raquel Ferrer-Oliveras ◽  
Erika Bonacina ◽  
Pablo Garcia-Manau ◽  
Carlota Rodo ◽  
...  
Keyword(s):  
Pilot Study ◽  
Fetal Growth ◽  
Pregnancy Outcomes ◽  
Fetal Growth Restriction ◽  
Early Onset ◽  
Maternal Serum ◽  
Angiogenic Factors ◽  
Interquartile Range ◽  
Growth Restriction ◽  
Control Group

Objective This study aimed to analyze the effect of pravastatin on angiogenic factors, feto–maternal Doppler findings and pregnancy outcomes in women with early-onset fetal growth restriction (FGR) treated with pravastatin compared with nontreated controls. Study Design This was a pilot study conducted between March 2016 and September 2017. Women with single pregnancies and FGR diagnosed at ≤ 28 weeks of gestation were offered 40 mg of pravastatin daily. Doppler progression, soluble fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) values, and pregnancy outcomes were assessed and compared with consecutive historical controls. Controls were matched to treated women for gestational age, maternal characteristics, maternal and obstetric history, Doppler severity classification, and angiogenic factors at diagnosis. The sFlt-1/PlGF was measured in maternal serum at two different times: before pravastatin was started (ratio M0) and during pravastatin treatment (ratio M1). Doppler severity was classified into four categories: normal, mild, moderate, and severe. Results A total of 38 women were enrolled in this study. No differences were observed in baseline characteristics between groups. However, when compared with the ratio M0, M1 was increased by a median (interquartile range) of 67.0 (−34.8 to 197.3) in the control group but decreased by a median (interquartile range) of −10.1 (−53.1 to −0.07) in the pravastatin treated group (p < 0.001). No significant differences were observed in Doppler progression throughout pregnancy. Median interval from diagnosis to delivery was extended by 16.5 days, the median newborn birthweight was increased from 1,040 to 1,300 g, and the number of women with preeclampsia decreased from 9 (47.4%) to 6 (31.6%) in treated women; however, these trends were not statistically significant. Conclusion In women with early-onset FGR, treatment with pravastatin 40 mg daily was associated with significant improvement in the angiogenic profile. Additionally, median pregnancy duration and median birthweight increased and the incidence of PE was reduced in treated women. Nevertheless, since this pilot study was underpowered, none of these differences were statistically significant. Key Points

scholarly journals 497: Angiogenic factors vs. standard evaluation in the prediction of adverse outcome among pregnancies with suspected fetal growth restriction

2018 ◽  
Vol 218 (1) ◽  
pp. S297-S298
Author(s):  
Ofer Beharier ◽  
shani Swissa ◽  
Irit Szaingurten-Solodkin ◽  
Asnat Walfisch ◽  
shimrt Yaniv-Salem ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Adverse Outcome ◽  
Angiogenic Factors ◽  
Growth Restriction

Characterization of fetal monocytes in preeclampsia and fetal growth restriction

2019 ◽  
Vol 47 (4) ◽  
pp. 434-438 ◽  
Author(s):  
Thushari I. Alahakoon ◽  
Heather Medbury ◽  
Helen Williams ◽  
Nicole Fewings ◽  
Xin M. Wang ◽  
...  
Keyword(s):  
Cord Blood ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Normal Pregnancy ◽  
Growth Restriction ◽  
Clinical Group ◽  
Monocyte Subset ◽  
Maternal Circulation ◽  
Cross Sectional ◽  
And Function

AbstractBackgroundThere is little available data on fetal monocyte phenotype and function. A prospective cross-sectional pilot study was conducted to describe the cord blood monocyte subset phenotype in preeclampsia (PE) and fetal growth restriction (FGR) as compared to normal pregnancy and maternal circulation.MethodsMaternal and cord blood samples from 27 pregnancies were collected at delivery from normal pregnancy, PE, FGR and PE+FGR. The distribution of fetal monocyte subtypes was characterized by CD14 and CD16 expression using flow cytometry and compared for each clinical group using a classification of classical, intermediate and non-classical subsets.ResultsThe intermediate monocytes were the dominant monocyte subset in the cord blood of PE and PE+FGR with an increase in the combined inflammatory monocyte subsets intermediate and non-classical in PE compared to normal pregnancy. The non-classical monocyte subset proportion was elevated in all pathological groups PE, FGR and PE+FGR. A significant reduction in the non-classical monocyte subset was observed in the cord blood of the normal pregnancy group as compared to the maternal circulation.ConclusionThis study describes for the first time in the fetal circulation, dominant monocyte intermediate subsets and increased inflammatory subsets in PE as well as increased non-classical subsets in PE and FGR compared to normal pregnancy.

OC08.05: Cardiac function in early childhood in relation to angiogenic factors in cord blood in fetal growth restriction

2014 ◽  
Vol 44 (S1) ◽  
pp. 19-19
Author(s):  
E. Llurba ◽  
Q. Ferrer ◽  
J. Candel ◽  
A. Ruiz ◽  
M. Gómez Roig ◽  
...  
Keyword(s):  
Early Childhood ◽  
Cardiac Function ◽  
Cord Blood ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Angiogenic Factors ◽  
Growth Restriction

scholarly journals DAAM2 is elevated in the circulation and placenta in pregnancies complicated by fetal growth restriction and is regulated by hypoxia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Natasha de Alwis ◽  
Sally Beard ◽  
Natalie K. Binder ◽  
Natasha Pritchard ◽  
Tu’uhevaha J. Kaitu’u-Lino ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mrna Expression ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Linear Regression Analysis ◽  
Growth Restriction ◽  
Oxidative Stress Marker ◽  
Small Interfering Rnas ◽  
Maternal Circulation ◽  
And Oxidative Stress

AbstractPreviously, we identified increased maternal circulating DAAM2 mRNA in pregnancies complicated by preterm fetal growth restriction (FGR). Here, we assessed whether circulating DAAM2 mRNA could detect FGR, and whether the DAAM2 gene, known to play roles in the Wnt signalling pathway is expressed in human placenta and associated with dysfunction and FGR. We performed linear regression analysis to calculate area under the ROC curve (AUC) for DAAM2 mRNA expression in the maternal circulation of pregnancies complicated by preterm FGR. DAAM2 mRNA expression was assessed across gestation by qPCR. DAAM2 protein and mRNA expression was assessed in preterm FGR placenta using western blot and qPCR. DAAM2 expression was assessed in term cytotrophoblasts and placental explant tissue cultured under hypoxic and normoxic conditions by qPCR. Small interfering RNAs were used to silence DAAM2 in term primary cytotrophoblasts. Expression of growth, apoptosis and oxidative stress genes were assessed by qPCR. Circulating DAAM2 mRNA was elevated in pregnancies complicated by preterm FGR [p < 0.0001, AUC = 0.83 (0.78–0.89)]. Placental DAAM2 mRNA was detectable across gestation, with highest expression at term. DAAM2 protein was increased in preterm FGR placentas but demonstrated no change in mRNA expression. DAAM2 mRNA expression was increased in cytotrophoblasts and placental explants under hypoxia. Silencing DAAM2 under hypoxia decreased expression of pro-survival gene, BCL2 and oxidative stress marker, NOX4, whilst increasing expression of antioxidant enzyme, HMOX-1. The increased DAAM2 associated with FGR and hypoxia implicates a potential role in placental dysfunction. Decreasing DAAM2 may have cytoprotective effects, but further research is required to elucidate its role in healthy and dysfunctional placentas.

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