scholarly journals Perioperative Screening Gastroscopy for Colorectal Cancer Patients Contributes to Early Detection of Gastric Cancer

2013 ◽  
Vol 24 ◽  
pp. iv112
Author(s):  
Takaharu Kato ◽  
Koichi Suzuki ◽  
Yuta Muto ◽  
Yutaka Kawamura ◽  
Junichi Sasaki ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gastric Cancer ◽  
Early Detection ◽  
Cancer Patients ◽  
Colorectal Cancer Patients

Early detection of cancer/testis mRNAs in tumor cells circulating in the peripheral blood of colorectal cancer patients

2012 ◽  
Vol 46 (5) ◽  
pp. 687-692 ◽  
Author(s):  
D. V. Novikov ◽  
T. V. Belova ◽  
E. S. Plekhanova ◽  
O. S. Yanchenko ◽  
V. V. Novikov
Keyword(s):  
Colorectal Cancer ◽  
Early Detection ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Peripheral Blood ◽  
Early Detection Of Cancer ◽  
Colorectal Cancer Patients ◽  
Cancer Testis

scholarly journals Quantitative Analysis of Methylated Adenosine Modifications Revealed Increased Levels of N6-Methyladenosine (m6A) and N6,2′-O-Dimethyladenosine (m6Am) in Serum From Colorectal Cancer and Gastric Cancer Patients

2021 ◽  
Vol 9 ◽  
Author(s):  
Yiqiu Hu ◽  
Zhihao Fang ◽  
Jiayi Mu ◽  
Yanqin Huang ◽  
Shu Zheng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gastric Cancer ◽  
Quantitative Analysis ◽  
Early Detection ◽  
Human Serum ◽  
Cancer Patients ◽  
Healthy Controls ◽  
Serum Samples ◽  
Gastrointestinal Malignancies ◽  
Gastric Cancer Patients

Colorectal cancer and gastric cancer are the most prevalent gastrointestinal malignancies worldwide, and early detection of these cancers is crucial to reduce their incidence and mortality. RNA methylation plays an important regulatory role in a variety of physiological activities, and it has drawn great attention in recent years. Methylated adenosine (A) modifications such as N6-methyladenosine (m6A), N1-methyladenosine (m1A), 2′-O-methyladenosine (Am), N6,2′-O-dimethyladenosine (m6Am), and N6,N6-dimethyladenosine (m62A) are typical epigenetic markers of RNA, and they are closely correlated to various diseases including cancer. Serum is a valuable source of biofluid for biomarker discovery, and determination of these adenosine modifications in human serum is desirable since they are emerging biomarkers for detection of diseases. In this work, a targeted quantitative analysis method using hydrophilic interaction liquid chromatography–tandem mass spectrometry (HILIC-MS/MS) was developed and utilized to analyze these methylated adenosine modifications in serum samples. The concentration differences between the healthy volunteers and cancer patients were evaluated by Mann–Whitney test, and receiver operator characteristic (ROC) curve analysis was performed to access the potential of these nucleosides as biomarkers. We demonstrated the presence of the m6Am in human serum for the first time, and we successfully quantified the concentrations of A, m6A, m1A, and m6Am in serum samples from 99 healthy controls, 51 colorectal cancer patients, and 27 gastric cancer patients. We found that the levels of m6A and m6Am in serum were both increased in colorectal cancer or gastric cancer patients, compared to that in healthy controls. These results indicate that m6A and m6Am in serum may act as potential biomarkers for early detection and prognosis of colorectal cancer and gastric cancer. In addition, the present work will stimulate investigations on the effects of adenosine methylation on the initiation and progression of colorectal cancer and gastric cancer.

scholarly journals Prevalence and Risk Factors of Gastric Adenoma and Gastric Cancer in Colorectal Cancer Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Dae Hyun Tak ◽  
Hee Seok Moon ◽  
Sun Hyung Kang ◽  
Jae Kyu Sung ◽  
Hyun Yong Jeong
Keyword(s):  
Colorectal Cancer ◽  
Gastric Cancer ◽  
Cancer Patients ◽  
Patient Group ◽  
Gastrointestinal Endoscopy ◽  
Control Group ◽  
Upper Gastrointestinal Endoscopy ◽  
Gastric Adenoma ◽  
Colorectal Cancer Patients ◽  
Upper Gastrointestinal

Background/Aims. To evaluate the incidence of gastric adenoma and gastric cancer in colorectal cancer patients, as well as the clinicopathological features that affect their incidence.Methods. Among patients who underwent surgery after being diagnosed with colorectal cancer between January 2004 and December 2013 at Chungnam National University Hospital, 142 patients who underwent follow-up upper gastrointestinal endoscopy were assigned to the patient group. The control group included 426 subjects randomly selected. The patient group was subdivided into two: one that developed gastric adenoma or cancer and one that did not. Clinicopathological characteristics were compared between these groups.Results. In total, 35 (24.6%) colorectal cancer patients developed a gastric adenoma or gastric cancer, which was higher than the number in the control group (20 [4.7%] patients;p<0.001). Age, alcohol history, and differentiation of colorectal cancer were associated with higher risks of gastric adenoma or gastric cancer, with odds ratios of 1.062, 6.506, and 5.901, respectively.Conclusions. In colorectal cancer patients, screening with upper gastrointestinal endoscopy is important, even if no lesions are noted in the upper gastrointestinal tract at colorectal cancer diagnosis. Endoscopic screening is particularly important with increasing age, history of alcohol consumption, and poor cancer differentiation.

Synchronous gastric cancer in primary sporadic colorectal cancer patients in Korea

2007 ◽  
Vol 23 (1) ◽  
pp. 61-65 ◽  
Author(s):  
S. B. Lim ◽  
S. Y. Jeong ◽  
H. S. Choi ◽  
D. K. Sohn ◽  
C. W. Hong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gastric Cancer ◽  
Cancer Patients ◽  
Sporadic Colorectal Cancer ◽  
Synchronous Gastric Cancer ◽  
Colorectal Cancer Patients

scholarly journals The importance of T-lymphocyte subsets on overall survival of colorectal and gastric cancer patients

Medicina ◽  
2007 ◽  
Vol 43 (7) ◽  
pp. 548 ◽  
Author(s):  
Vida Milašienė ◽  
Eugenijus Stratilatovas ◽  
Violeta Norkienė
Keyword(s):  
Colorectal Cancer ◽  
Gastric Cancer ◽  
Overall Survival ◽  
Cancer Patients ◽  
Cellular Immunity ◽  
Lymphocyte Subsets ◽  
Absolute Number ◽  
Stage Iii ◽  
Gastric Cancer Patients ◽  
Colorectal Cancer Patients

The aim of this study was to evaluate the influence of cellular immunity parameters on overall survival of colorectal and gastric cancer patients after surgery. The parameters of cellular immunity (CD3+, CD4+, CD8+, CD20+, and CD16+) were determined by immunofluorescence method. Cox regression analysis showed no impact of the estimated preoperative and postoperative parameters of cellular immunity on overall survival of colorectal cancer patients and similarly of gastric cancer patients in stage II. However, the analysis showed that the survival of colorectal and gastric cancer patients in stage III depended on immunological parameters determined before surgery: CD3+ (P=0.007 and P=0.007, respectively), CD4+ (P=0.021 and P=0.011, respectively), and CD8+ (P=0.047 and P=0.007) counts. Only the survival of colorectal cancer patients depended on natural killer cell number (P=0.009). Kaplan-Meier analysis showed that patients with stage III colorectal and gastric cancer had better survival rates when absolute number of CD3+ lymphocytes, determined before surgery, was greater than 0.8×109/L, CD4+ – greater than 0.25×109/L, CD8+ – greater than 0.3×109/L. Colorectal cancer patient survived longer when the number of natural killer cells CD16+ was more than 0.25×109/L. This study suggests that higher levels of the absolute number of lymphocyte subsets before surgery have a beneficial effect on overall survival of gastric and colorectal cancer patients in stage III.

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