Social Cognition Tests Can Discriminate Behavioral Variant Frontotemporal Dementia From Alzheimer’s Disease Independently of Executive Functioning

2020 ◽  
Author(s):  
Millena Vieira Brandão Moura ◽  
Luciano Inácio Mariano ◽  
Antônio Lúcio Teixeira ◽  
Paulo Caramelli ◽  
Leonardo Cruz de Souza
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Social Cognition ◽  
Frontotemporal Dementia ◽  
Area Under The Curve ◽  
Facial Emotion ◽  
Short Version ◽  
Executive Performance ◽  
Social And Emotional ◽  
The Social

Abstract Objective To investigate the accuracy of the Social and Emotional Assessment-short version (Mini-SEA) to differentiate subgroups of behavioral variant of frontotemporal dementia (bvFTD) and Alzheimer’s disease (AD) defined according to executive performance. Methods bvFTD (n = 21), AD (n = 20), and healthy controls (HC, n = 23) underwent the Mini-SEA, comprising the Facial Emotion Recognition Test (FERT) and the faux-pas test. AD and bvFTD patients were classified according to their performance in the Frontal Assessment Battery into dysexecutive and nondysexecutive subgroups. Results The area under the curve (AUC) values for the faux-pas test were 0.87 (dysexecutive-bvFTD vs. dysexecutive-AD) and 0.96 (non-dysexecutive-bvFTD vs. nondysexecutive-AD). The AUC values for FERT were 0.99 (dysexecutive-bvFTD vs. dysexecutive-AD) and 0.65 (nondysexecutive-bvFTD vs. nondysexecutive-AD); the AUC values for the Mini-SEA (total-score) were 0.95 (dysexecutive-bvFTD vs. dysexecutive-AD) and 0.88 (nondysexecutive-bvFTD vs. nondysexecutive-AD). Discussion Social Cognition tests accurately distinguish bvFTD from AD regardless of the executive profile.

scholarly journals Play and Possibility

2021 ◽  
Vol 9 (2) ◽  
pp. 135-151
Author(s):  
Avril Tynan
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Narrative Fiction ◽  
Cultural Representations ◽  
Social And Emotional ◽  
The Social ◽  
The Face

Cultural representations of Alzheimer’s disease typically focus on the social and emotional burdens felt by family and friends, diluting or excluding the experience of the sufferer. This article demonstrates how narrative fiction may help us to engage with the experiences of individuals with Alzheimer’s disease by imagining what it might be like to suffer from the disease ourselves. Demonstrating the humanized and subjective understanding of Alzheimer’s disease articulated in Olivia Rosenthal’s (2007) On n’est pas là pour disparaître [We’re Not Here to Disappear (2015)] this article also exposes the limitations of narrative fiction as a means of highlighting our own ignorance in the face of others’ experiences.

scholarly journals THE ADDENBROOKE’S COGNITIVE EXAMINATION–REVISED (ACE-R) IN THE DIFFERENTIAL DIAGNOSIS BETWEEN ALZHEIMER’S DISEASE AND BEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIA: A POWERFUL LOGARITHM

2021 ◽  
Author(s):  
Viviane Amaral- Carvalho ◽  
Thais Lima- Silva ◽  
Luciano Mariano ◽  
Leonardo de Souza ◽  
Henrique Guimarães ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Logistic Regression ◽  
Differential Diagnosis ◽  
Frontotemporal Dementia ◽  
Latent Trait ◽  
Area Under The Curve ◽  
Scaling Analysis ◽  
Roc Curve Analysis ◽  
Behavioral Variant Frontotemporal Dementia

Background: The differential diagnosis between Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) is challenging, justifying improvement of cognitive tools for use in clinical practice. Objective: To develop a new logarithm based on discriminative items of the ACE-R. Methods: The ACE-R was administered to 102 patients with mild dementia due to probable AD and 37 with mild probable bvFTD. Mokken scaling analysis was applied to identify the latent trait on the AD Group. Multivariate logistic regression and ROC curve analysis were carried out. Results: Mean total scores in ACE-R were 70.2 ± 10.8 in AD and 72.2 ± 11.1 in bvFTD. AD Mokken ACE-R (AMokACE-R) comprises 12 items measuring the same latent concept. Logistic regression with cross-validation pointed that AMokACE-R + Age + Sex-male + ACE-R subitems Orientation and Memory share importance as independent variables (p <0.05). The proposed logarithm reached an area under the curve of 0.922, with 88% sensitivity/specificity, 71% PPV and 96% NPV. Conclusion: The new logarithm using the ACE-R achieved high diagnostic accuracy in discriminating AD and bvFTD, showing superiority to previous findings. Further analysis in larger samples, with biomarkers or pathological confirmation, are necessary to confirm these findings.

scholarly journals Frontotemporal dementia to Alzheimer's disease

2007 ◽  
Vol 9 (2) ◽  
pp. 153-160
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Dementia ◽  
Behavioral Changes ◽  
Neural Damage ◽  
Personality Changes ◽  
The Social ◽  
Long Time ◽  
And Behavior ◽  
The Relationship

Behavioral manifestations may dominate the clinical picture of the frontal variant of frontotemporal dementia (fv-FTD) for a long time before the appearance of true cognitive deficits. On the other hand, a deficit in the episodic memory domain represents the main manifestation of Alzheimer's disease (AD). Many behavioral disorders have been described in the clinical course of both FTD and AD; however, apathy and personality changes characterize frontal dementias, while depression dominates in AD, at least in the earlier stages. Depending on the distribution of neural damage, different patterns of noncognitive manifestations may be expected in different subtypes of FTD. Recent research on the social cognition deficit in FTD has offered new insights into the relationship between cognition and behavior, suggesting that some aspects of the behavioral changes in dementia may be generated by impairment in this domain.

The effects of gender, age, schooling, and cultural background on the identification of facial emotions: a transcultural study

2018 ◽  
Vol 30 (12) ◽  
pp. 1861-1870 ◽  
Author(s):  
Leonardo Cruz de Souza ◽  
Maxime Bertoux ◽  
Ângelo Ribeiro Vaz de Faria ◽  
Laiane Tábata Souza Corgosinho ◽  
Ana Carolina de Almeida Prado ◽  
...  
Keyword(s):  
Educational Level ◽  
Normative Data ◽  
Cultural Background ◽  
Facial Emotion ◽  
Short Version ◽  
Brazilian Sample ◽  
Social And Emotional ◽  
The Social ◽  
The Common ◽  
Transcultural Study

ABSTRACTBackground:Social cognition tasks, such as identification of emotions, can contribute to the diagnosis of neuropsychiatric disorders. The wide use of Facial Emotion Recognition Test (FERT) is hampered by the absence of normative dataset and by the limited understanding of how demographic factors such as age, education, gender, and cultural background may influence the performance on the test.Methods:We analyzed the influence of these variables in the performance in the FERT from the short version of the Social and Emotional Assessment. This task is composed by 35 pictures with 7 different emotions presented 5 times each. Cognitively healthy Brazilian participants (n = 203; 109 females and 94 males) underwent the FERT. We compared the performance of participants across gender, age, and educational subgroups. We also compared the performance of Brazilians with a group of French subjects (n = 60) matched for gender, age, and educational level.Results:There was no gender difference regarding the performance on total score and in each emotion subscore in the Brazilian sample. We found a significant effect of aging and schooling on the performance on the FERT, with younger and more educated subjects having higher scores. Brazilian and French participants did not differ in the FERT and its subscores. Normative data for employing the FERT in Brazilian population is presented.Conclusions:Data here provided may contribute to the interpretation of the results of FERT in different cultural contexts and highlight the common bias that should be corrected in the future tasks to be developed.

Can Social Cognition Measurements Differentiate Behavioral Variant Frontotemporal Dementia from Alzheimer’s Disease Regardless of Apathy?

2020 ◽  
Vol 74 (3) ◽  
pp. 817-827 ◽  
Author(s):  
Luciano Inácio Mariano ◽  
Paulo Caramelli ◽  
Henrique Cerqueira Guimarães ◽  
Leandro Boson Gambogi ◽  
Millena Vieira Brandão Moura ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Social Cognition ◽  
Frontotemporal Dementia ◽  
Behavioral Variant Frontotemporal Dementia

scholarly journals Social Cognition Deficits: The Key to Discriminate Behavioral Variant Frontotemporal Dementia from Alzheimer’s Disease Regardless of Amnesia?

2015 ◽  
Vol 49 (4) ◽  
pp. 1065-1074 ◽  
Author(s):  
Maxime Bertoux ◽  
Leonardo Cruz de Souza ◽  
Claire O’Callaghan ◽  
Andrea Greve ◽  
Marie Sarazin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Social Cognition ◽  
Frontotemporal Dementia ◽  
Behavioral Variant Frontotemporal Dementia
Sign in / Sign up

Export Citation Format

Share Document