Comparison of induction of sister chromatid exchange, 8-azaguanine- and ouabain-resistant mutants by cyclophosphamide, ifosfamide and 1-(pyridyl-3)-3, 3-dimethyltriazene in Chinese hamster cells cultured in diffusion chambers in mice

1980 ◽  
Vol 1 (4) ◽  
pp. 353-355 ◽  
Author(s):  
S.R. Sirianni ◽  
C.C. Huang
Keyword(s):  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Chinese Hamster ◽  
Diffusion Chambers ◽  
Chinese Hamster Cells ◽  
Resistant Mutants ◽  
Cells Cultured

An Evaluation of the Genotoxicity of O-Tyrosine, a Proposed Marker for Irradiated Food

1992 ◽  
Vol 55 (12) ◽  
pp. 1006-1008 ◽  
Author(s):  
JOSEPH G. SZEKELY ◽  
NOEMI CHUAQUI-OFFERMANNS ◽  
MARLENE GOODWIN ◽  
SABINE DELANEY
Keyword(s):  
Growth Rate ◽  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Chinese Hamster ◽  
Human Cells ◽  
Chinese Hamster Cells ◽  
Irradiated Food ◽  
In Cells

V79 Chinese hamster cells and Molt-4 human cells have been used to test the cellular and genetic toxicities of o-tyrosine addition at concentrations far in excess of that found after irradiation of chicken to 10 kGy (~1.3 μg/ml). No toxicity, as measured by sister chromatid exchange, micronuclei formation, or reproductive death, was seen in cells exposed to concentrations up to 100 μg/ml o-tyrosine. After 2 d in 200 μg/ml o-tyrosine, Molt-4 cells had a higher percentage of dead cells in the population, but the growth rate and micronuclei formation were not affected.

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